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| 1 | Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer显示文摘Colorectal cancer(CRC)is one of the most common cancer worldwide and results from the accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to cell proliferation and metastasis.Unfortunately,CRC prognosis is still poor and the search of novel diagnostic and prognostic biomarkers is highly desired to prevent CRC-related deaths.The present article aims to summarize the most recent findings concerning the use of either genetic or epigenetic(mainly related to DNA methylation)biomarkers for CRC diagnosis,prognosis,and response to treatment.Recent large-scale DNA methylation studies suggest that CRC can be divided into several subtypes according to the frequency of DNA methylation and those of mutations in key CRC genes,and that this is reflected by different prognostic outcomes.Increasing evidence suggests that the analysis of DNA methylation in blood or fecal specimens could represent a valuable non-invasive diagnostic tool for CRC.Moreover,a broad spectrum of studies indicates that the inter-individual response to chemotherapeutic treatments depends on both epigenetic modifications and genetic mutations occurring in colorectal cancer cells,thereby opening the way for a personalized medicine.Overall,combining genetic and epigenetic data might represent the most promising tool for a proper diagnostic,prognostic and therapeutic approach. | Fabio Coppedè Angela Lopomo Roberto Spisni Lucia Migliore | 2014 | World Journal of Gastroenterology2014，20，4： | 29 |
| 2 | Genetics, Cytogenetics, and Epigenetics of Colorectal Cancer显示文摘 | Lucia Migliore Francesca Migheli Roberto Spisni Fabio Coppedè Nathan A. Ellis | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 2 |
| 3 | Colocalization prostacyclin (PGI2) synthase-caveolin-1 in endothelial cells and new roles for PGI2 in angiogenesis显示文摘 | Spisni E Griffoni C Santi S | 2001 | Exp Cell Res2001，266，1： | 1 |
| 4 | Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine 显示文摘 | Yount NY Kupferwasser D Spisni A | 2009 | Proc Natl Acad Sci U S A2009，106，14： | 1 |
| 5 | Involvement of caveolae and caveolae-like domains in signalling cell survival and angiogenesis显示文摘 | Griffoni C Spisni E | 2002 | Celluar Signalling2002，14，： | 1 |
| 6 | Structural insights into the function of human caveolin1显示文摘 | Spisni E Tomasi V Cestaro A | 2005 | Biochem Biophys Res Commun2005，338，3： | 1 |
| 7 | Structural insights into the function of human caveolin 1 显示文摘 | Spisni E Tomasi V Cestaro A | 2005 | Biochemical and Biophysical Research Communications2005，338，： | 1 |
| 8 | Neoangiogenesis in colon cancer:correlation between vascular density,vascular endothelial growth factor (VEGF) and p53 protein expression显示文摘 | Boldrini L Spisni R | 2002 | Oncol Rep2002，9，3： | 1 |
| 9 | RNA interference as a key to knockdown overexpressed cyclooxygenase-2 gene in tumour cells 显示文摘 | Strillacci A Griffoni C Spisni E | 2006 | Br J Cancer2006，94，9： | 1 |
| 10 | Involvement of caveolae and caveolae-like domains in signalling, cell survival and angiogenesis显示文摘 | Massimino ML Griffoni C Spisni E | 2002 | Cell Signal2002，14，： | 1 |
| 11 | Involvement of prostanoids in the regulation of angiogenesis by polypeptide growth factors显示文摘 | Spisni E Manica F Tomasi V | 1992 | Prostaglandins Leukot Essent Fatty Acids1992，47，2： | 1 |
| 12 | Neoangiogenesis in colon cancer: correlation between vascular density, vascular endothelial growth factor(VEGF) and P53 protein expression 显示文摘 | Faviana P Boldrini L Spisni R | 2002 | Oncol Reports2002，9，： | 1 |
| 13 | Neoangiogenesis in colon cancer:correlation between vascular density ,vascular endothelial growth factor(VEGF) and P53 protein expression显示文摘 | Faviana P Boldrini L Spisni R | 2002 | Oncol Rep2002，9，3： | 1 |
| 14 | RNA interference as a key to knockdown overexpressed cyclooxygenase-2 gene in tumour cells显示文摘 | Strillacci A Griffoni C Spisni E | 2006 | Br J Cancer2006，94，9： | 1 |
| 15 | Genetics,cytogenetics,and epigenetics of colorectal cancer显示文摘 | Migliore L Migheli F Spisni R | | 0，，： | 1 |
| 16 | Structural insights into the function of human caveolin-1 显示文摘 | Spisni E Tomasi V Cestaro A | 2005 | Biochem Biophys Res Commun2005，338，3： | 1 |
| 17 | Knockdown of caveolin-1 by antisense oligonucleotides impairs angiogenesis in vitro and in vivo 显示文摘 | Griffoni C Spisni E Santi S | 2000 | Biochem Biophys Res Commun2000，276，2： | 1 |
| 18 | Hepatic steatosis in artificially fed marine teleosts 显示文摘 | Spisni E Tugnoli M Ponticelli A | 1998 | Journal of Fish Diseases1998，21，： | 1 |
| 19 | RNA interference as a key to knockdown overexpressed cyclooxygenase -2 gene in tumour cells 显示文摘 | Strillacci A Griffoni C Spisni E | 2006 | Br J Cancer2006，94，9： | 1 |
| 20 | Structural insights into the function of human caveolin 1 显示文摘 | Spisni E Tomasi V Cestaro A | 2005 | Biochem Biophys Res Commun2005，338，3： | 1 |
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