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145篇 您的检索式:作者名="Spitzer H"
    题名 作者 年代 出处 被引量
1Formation mechanisms of sub-micron pharmaceutical composite particles derived from far-and near-field Raman microscopy显示文摘Surface enhanced Raman spectroscopy(SERS) and confocal Raman microscopy are applied to investigate the structure and the molecular arrangement of sub-micron furosemide and polyvinylpyrrolidone(furosemide/PVP) particles produced by spray flash evaporation(SFE). Morphology, size and crystallinity of furosemide/PVP particles are analyzed by scanning electron microscopy(SEM) and X-ray powder diffraction(XRPD). Far-field Raman spectra and confocal far-field Raman maps of furosemide/PVP particles are interpreted based on the far-field Raman spectra of pure furosemide and PVP precursors.Confocal far-field Raman microscopy shows that furosemide/PVP particles feature an intermixture of furosemide and PVP molecules at the sub-micron scale. SERS and surface-enhanced confocal Raman microscopy(SECo RM) are performed on furosemide, PVP and furosemide/PVP composite particles sputtered with silver(40 nm). SERS and SECo RM maps reveal that furosemide/PVP particle surfaces mainly consist of PVP molecules. The combination of surface and bulk sensitive analyses reveal that furosemide/PVP sub-micron particles are formed by the agglomeration of primary furosemide nanocrystals embedded in a thin PVP matrix. Interestingly, both far-field Raman microscopy and SECo RM provide molecular information on a statistically-relevant amount of sub-micron particles in a single microscopic map;this combination is thus an effective and time-saving tool for investigating organic sub-micron composites.Jakob Hübner Jean-Baptiste Coty Yan Busby Denis Spitzer 2021Journal of Pharmaceutical Analysis2021,11,4:2
2Toll-like receptorl inhibits Toll-like receptor 4 signaling in endothelis cells显示文摘Spitzer J H Visintin A Mazzoni A 2002Eur J Immunol2002,32,4:1
3Alimit law for random walk in a random environment显示文摘KESTEN H KOZLOV M SPITZER F 1975Comp Math1975,30,:1
4Application of rorating magnetic fields in czochralski crystal growth显示文摘Spitzer K H 1999Progress in Crystal Growth and Characterization of Materials1999,38,1:1
5Application of reduction of area-temperature diagrams to the prediction of surface crack formation in continuous casting of steel显示文摘SCHWERDTFEGER K SPITZER K H 2009ISIJ International2009,49,4:1
6Increased left prefrontal activation in patients with unipolar depression:An event-related,parametric,performance-controlled fMRI study显示文摘Walter H Wolf RC Spitzer M 2007Journal of Affective Disorders2007,101,13:1
7Effectof oxide layers on spray water cooling heat transfer athigh surface temperature显示文摘Wendelstorf R Spitzer K H Wendelstorf J 2008International Journal ofHeat and Mass Transer2008,51,1920:1
8Sarcoplasmic reticulum and Na^+/Ca^2+ exchanger function during early and late relaxation in ventricular myocytes显示文摘Yao A Matsui H Spitzer KW 1997Am J Physiol1997,273,6:1
9DMSO is a strong inducer of DNA hydroxymethylation in pre-osteoblastic MC3T3-EI cells 显示文摘Thaler 1L Spitzer S Karlic H 2012Epigenetics2012,7,6:1
10Closum or nonclosure visceral peritoneum at cesarean delivery显示文摘NAGELE F KARAS H SPITZER D 1996Am J Obstet Gynecol1996,174,:1
11Multi-frequency electromagnetic stirring of liquid metals 显示文摘K H Spitzer Georg Reiter Klaus Schwerdtfeger 1996IS1J international1996,36,5:1
12Closure or nonclosure of the Visveral Peritoneum at cesarean delivery 显示文摘Nagele F Karas H Spitzer D 1996Am J Gynecol1996,174,:1
13A limit law for random walk in a random environment显示文摘 KOZLOV M SPITZER F 1975Comp Math1975,30,:1
14Conservative treatment of cervical pregnancy by curettage and local prostaglandin injection 显示文摘Spitzer D Steiner H Graf A 1997Hum Reprod1997,12,4:1
15Closure or nonclosure of the visceral peritoneum at cesarean delivery显示文摘Nagele F Karas H Spitzer D 1996Am J Obster Gynecol1996,174,:1
16Newborn hearing screening in the NICU: profile of failed auditory brainstem response/passed otoacoustic emission 显示文摘BERG A L SPITZER J B TOWERS H M 2005Pediatrics2005,116,:1
17Toll - like receptor 1 inhibits Toll - like receptor 4 signaling in endothelia cells显示文摘SPITZER J H VISINTIN A MAZZONI A 2002Eur J Immunol2002,32,4:1
18Rotational electromagnetic stirring in continuous casting of round strands显示文摘Spitzer K H Dubke M Schwerdtfeger K 1986Metallu Trans B1986,17,3:1
19Closure or nonclosure of the visceral peritoneum at cesaean detivery显示文摘Nagete F Karas H Spitzer D 1996Am J Obstet Gynecol1996,174,:1
20Three-dimensional ultrasound in prenatal diagnosis of skeletal dysplasia显示文摘Steiner H Spitzer D Weiss-Wichert PH 1995Prenatal Diagnosis1995,15,:1
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