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| 1 | Synthesis of some sugar nitrates显示文摘 | Leicach S R Sproviero J F Sproviero J F | | 0，，02： | 1 |
| 2 | Computational insights into the O2-evolving complex of photosystem II显示文摘 | Sproviero E M McEvoy J P Gascon J A | 2008 | Photosynth Reseaches2008，97，1： | 1 |
| 3 | Development of an Objective Scoring System for Measurement of Resident Performance on the Human Patient Simulator 显示文摘 | Scavone BM Sproviero MT McCarthy RJ | 2006 | Anesthesiology2006，105，2： | 1 |
| 4 | Transforming growth faetor-betal is constitutively secreted by Chinese hamster ovary cells and is functional in human cells 显示文摘 | BEATSON R SPROVIERO D MAHER J | 2011 | Bioteehnol Bio- eng2011，108，11： | 1 |
| 5 | Development of an objective scoring system for measurement of resident performance on the human patient simulator 显示文摘 | Scavone BM Sproviero MT McCarthy RJ | 2006 | Anesthesiology2006，105，2： | 1 |
| 6 | Development of an objective scoring system for measurement of resident performance on the human patient simulator显示文摘 | SCAVONE BM SPROVIERO MT MCCARTHY RJ | 2006 | Anesthesiology2006，105，2： | 1 |
| 7 | 血压升高与痴呆风险:英国生物样本库两样本孟德尔随机研究显示文摘众多随机对照研究的结果对血压与痴呆的相关性存在争议。本研究假设收缩压和/或舒张压与阿尔茨海默病(Alzheimer's disease,AD)存在因果关系,并进行验证。方法:本研究利用299024名个体的全基因组相关性研究荟萃分析数据进行了广义孟德尔随机(generalized summary Mendelian randomization,GSMR)分析,以收缩压或舒张压作为暴露变量,有三种不同情况:①AD诊断(AD国际基因组学项目),②AD母系家族史(英国生物样本库),③父系家族史(英国生物样本库)。 | 袁源(摘译) 郑武洪(审校) Sproviero W Winchester L Newby D Fernandes M Shi L Goodday SM Prats-Uribe A Alhambra DP Buckley NJ Nevado-Holgado AJ | 2021 | 中华高血压杂志2021，29，7： | 0 |
| 8 | Hydroxychloroquine modulates immunological pathways activated by RNA:DNA hybrids in Aicardi–Goutières syndrome patients carrying RNASEH2 mutations显示文摘Aicardi–Goutières syndrome(AGS)is a rare genetic disease caused by mutations in nine genes that are all involved in nucleic acid metabolism or sensing.1,2 The three RNASEH2 subunits represent the most frequently mutated genes in AGS patients,1,3 and mutations in RNASEH2 subunits lead to the accumulation of endogenous RNA:DNA hybrids that may trigger an interferon-α-mediated immune response4 through the activation of pattern recognition receptors(PRRs).5 PRRs perform surveillance on extracellular,endosomal,and cytosolic compartments to identify signs of infection:endogenous nucleic acids that are inappropriately cleared may enter and accumulate in the cytoplasm,driving inflammation and autoimmune diseases.6 This accumulation may be the cause of the clinical autoimmune phenotype of AGS patients carrying RNASEH2 mutations.A proven effective cure for AGS has not been discovered,and targeting these two pathways may lead to a treatment that improves patients’immunological symptoms.Hydroxychloroquine(HCQ)interferes with normal antigen processing and presentation and is widely used in the clinical treatment of autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.7 HCQ is also a well-known inhibitor of autophagy that prevents the degradation of autolysosomes.This drug inhibits acidification and maturation of endosomes and increases the pH in lysosomes,resulting in the inhibition of their main functions,such as downstream cell signaling through TLRs.7 Therefore,the aim of our work was to investigate whether HCQ is able to modulate the abnormal inflammatory response driven by RNA:DNA hybrids. | Jessica Garau Daisy Sproviero Francesca Dragoni Elisa Piscianz Carolina Santonicola Davide Tonduti Stephana Carelli Alessandra Tesser Gian Vincenzo Zuccotti Alberto Tommasini Simona Orcesi Orietta Pansarasa Cristina Cereda | 2021 | Cellular & Molecular Immunology2021，18，6： | 0 |
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