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| 1 | Diabetic cardiomyopathy:Pathophysiology,diagnostic evaluation and management显示文摘Diabetes affects every organ in the body and cardiovascular disease accounts for two-thirds of the mortality in the diabetic population.Diabetes-related heart disease occurs in the form of coronary artery disease(CAD),cardiac autonomic neuropathy or diabetic cardiomyopathy(DbCM).The prevalence of cardiac failure is high in the diabetic population and DbCM is a common but underestimated cause of heart failure in diabetes.The pathogenesis of diabetic cardiomyopathy is yet to be clearly defined.Hyperglycemia,dyslipidemia and inflammation are thought to play key roles in the generation of reactive oxygen or nitrogen species which are in turn implicated.The myocardial interstitium undergoes alterations resulting in abnormal contractile function noted in DbCM.In the early stages of the disease diastolic dysfunction is the only abnormality,but systolic dysfunction supervenes in the later stages with impaired left ventricular ejection fraction.Transmitral Doppler echocardiography is usually used to assess diastolic dysfunction,but tissue Doppler Imaging and Cardiac Magnetic Resonance Imaging are being increasingly used recently for early detection of DbCM.The management of DbCM involves improvement in lifestyle,control of glucose and lipid abnormalities,and treatment of hypertension and CAD,if present.The role of vasoactive drugs and antioxidants is being explored.This review discusses the pathophysiology,diagnostic evaluation and management options of DbCM. | Joseph M Pappachan George I Varughese Rajagopalan Sriraman Ganesan Arunagirinathan | 2013 | World Journal of Diabetes2013，4，5： | 57 |
| 2 | Incretin manipulation in diabetes management显示文摘Incretin-based therapies have revolutionized the medical management of type 2 diabetes mellitus(T2DM) in the 21 st century. Glucagon-like peptide-1(GLP-1) suppresses appetite and gastric motility, and has trophic effects on pancreas, cardio-protective and renal effects. GLP-1 analogues and dipeptidyl peptidase-4 inhibitors form the incretin-based therapies. Significant reduction of hemoglobin A1 c when used as monotherapy and in combination regimens, favorable effects on body weight, and low risk of hypoglycemia are their unique therapeutic benefits. Their safety and tolerability are comparable to other anti-diabetic medications. Concern about elevated risk of pancreatitis has been discarded by two recent meta-analyses. This article discusses the therapeutic manipulation of incretin system for the management of T2 DM. | Joseph M Pappachan AV Raveendran Rajagopalan Sriraman | 2015 | World Journal of Diabetes2015，6，6： | 6 |
| 3 | Friction transitions and connections to third bodies for a Cd coating on steel substrate显示文摘Cd coating is used in aerospace industries from last five decades due to its sacrificial protection and lubrication properties. Although Cd coating is primarily used due to its sacrificial corrosion protection when applied on steel substrate, the added benefit of modifying the tribological behavior by acting as a lubricious layer gives it a leading-edge than other coatings. Often the measurement of friction coefficient (CoF) is reported as a value generated after full sliding cycle. This measurement of average CoF generally limits the study of local variation in CoF occurring within one sliding cycle, which can be significantly different with change in spatial position due to change in third body morphology. In this study, a linearly reciprocating sliding test is used to measure the CoF at a sampling rate of 800 Hz along the track length to generate triboscopic image with steel countersphere. The instantaneous CoF obtained with triboscopy is correlated with the wear track morphology using scanning electron microscope (SEM) and optical profilometer for variation in contact conditions. Tribological test performed in dry atmosphere shows an average CoF of 0.4 till the end of the test whereas with increase in relative humidity to 60%, the average CoF changes from 0.4 to 0.8 at the end of the test due to change in contact conditions. Soft Cd coating on low carbon steel substrate is used to study these variations in third body morphology. | Priyadarshi BEHERA Lisa LEE Sriraman K.RAJAGOPALAN Richard R.CHROMIK Stephen YUE | 2020 | Friction2020，8，4： | 2 |
| 4 | Cloning, expres-sion and evaluation of the efficacy of a recombinant Eimeria tenel-la sporozoite antigen in birds显示文摘 | Subramanian BM Sriraman R RaoNH | 2008 | Vaccine2008，26，2728： | 1 |
| 5 | Plant expressedcoccidial antigens as potential vaccine candidates in protectingchicken against coccidiosis显示文摘 | Sathish K Sriraman R Subramanian BM | 2012 | Vaccine2012，30，30： | 1 |
| 6 | Small nuclear RING finger protein expression during gonad development: regulation by gonadotropins and estrogen in the postnatal ovary显示文摘 | Hirvonen-Santti S J Sriraman V Anttonen M | 2006 | Endoerinology2006，145，： | 1 |
| 7 | Recombinant anti-CG antibodies retained in the endoplasmic reticulum of transformed plants lack core-xylose and core-(1,3)-fucose residues显示文摘 | Sriraman R Bardor M Sack M | 2004 | Plant Biotechnology Journal2004，2，4： | 1 |
| 8 | Thermo-mechanical finite element analysis of a rail wheel显示文摘 | Amanan L Krishna K R Sriraman R | 1999 | International Journal of Mechanical Sciences1999，41，： | 1 |
| 9 | Barriers todrug delivery in solid tumors 显示文摘 | Sriraman SK Aiysofnayajula B Torchilin VP | 2014 | Tissue Barriers2014，2，3： | 1 |
| 10 | Mechanism of hydrogen-induced crystallization of amorphous silicon显示文摘 | SRIRAMAN S AGARWAL S AYDIL E S | 2002 | Nature2002，418，6893： | 1 |
| 11 | Fatigue Crack Growth of Bonded Composite Repairs inGiga Cycle Regime显示文摘 | WANG Q Y SRIRAMAN M R KAWAGOISHI N | 2006 | International Journal of Fatigue2006，，28： | 1 |
| 12 | Corrosion behaviour of electrodeposited nanocrystalline Ni W and Ni-Fe-W alloys显示文摘 | Sriraman K R Ganesh Sundara Raman | 2007 | Mater Sci Eng A2007，，： | 1 |
| 13 | Corrosion behaviour of electrodeposited nanocrys talline Ni-W and NbFe-W alloys显示文摘 | SRIRAMAN K R GANESH S R S SESHADRI S K | 2007 | Materials Sci- ence and Engineering: A2007，46，： | 1 |
| 14 | Small nuclear RING finger protein expression during gonad development: regulation by gonadotropins and estrogen in the postnatal ovary 显示文摘 | HIRVONEN-SANTTI S J SRIRAMAN V ANTTONEN M | 2004 | Endocrinology2004，145，5： | 1 |
| 15 | De velopment of foot-and-mouth disease virus (FMr)V) serotype O virus-like-particles (VLPs) vaccine and evaluation of its po tency显示文摘 | Subramanian B M Madhanmohan M Sriraman R | 2012 | Antiviral Res2012，44，： | 1 |
| 16 | A simple and rap- id method to monitor the disassembly and reassembly of virus-like particles显示文摘 | Rajendar B Sivakumar V Sriraman R | 2013 | Anal Biochem2013，440，1： | 1 |
| 17 | Plant expressed EtMIC2 is an effective immunogen in conferring protection against chicken coccidiosis 显示文摘 | SATHISH K SRIRAMAN R SUBRAMANIAN B M | 2011 | Vaccine2011，29，49： | 1 |
| 18 | Plant expressed Coccidial antigens as potential vaccine candidates in protecting chicken against Coccidiosis显示文摘 | SATHISH K SRIRAMAN R SUBRAMANIAN B M | 2012 | Vaccine2012，30，30： | 1 |
| 19 | Effect of embedment length of untreated natural fibres on the bond behaviour in cement mortar显示文摘The present investigation is focused on studying the effects of various matrices with 1:3,1:4and 1:5 mortars and fibre types of sisal and coir on the bond behavior at various ages of curing,i.e.,24h,3d,7d and 28d.The other parameters included in the investigation are water/cement (w/c)ratio,sand gradation and embedment length of fibres.In addition,the type of failure of sisal and coir fibres for different mixes of mortars at various curing ages is also reported.From the results,it is seen that the bond strength is improving with respect to age of curing in case of sisal fibres, but decreases in case ofcoir fibres.The failure of fibres due to fibre fracture is observed in sisal fibres and fibre pullout is observed in coir fibres.The other varying parameters such as mortar mixes,sand gradation,w/c ratio and embedded length also showed significant effect on bond behaviour of sisal and coir fibre with the cement mortar mixes. | Gudimella RAMAKRISHNA Sriraman PRIYADHARSHINI | 2018 | Frontiers of Structural and Civil Engineering2018，12，4： | 1 |
| 20 | Corrosion behaviour of electrodeposited nanocrystalline Ni–W and Ni–Fe–W alloys显示文摘 | K.R. Sriraman S. Ganesh Sundara Raman S.K. Seshadri | 2007 | Materials Science & Engineering A2007，，： | 1 |
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