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| 1 | 胎儿期恰逢1959~1961年饥荒的中国成人精神分裂症的发病率显示文摘背景:精神分裂症是一种常见的中度精神障碍。子宫内营养缺乏可增大患精神分裂症的危险。其主要依据来自1944~1945年荷兰饥饿冬天(Dutch Hunger Winter)研究,当时食品摄入在短期内极剧下降。这项有关饥荒期间受孕人群的大型队列研究显示,发生精神分裂症的危险增大两倍。
目的:确定经受1959~1961年大饥荒的中国人是否有相似的结果。
设计、地点及参试者:发生精神分裂症危险的调查于安徽省芜湖地区进行,这是当初受灾最重的地区之一。对饥荒之前、饥荒期间和饥荒以后出生的人群发病率进行比较。芜湖及其周围6个县是由一所精神病院负责的。对1971~2001年所有的精神病病历记录均进行检查。精神分裂症患者的临床和社会人口学资料由对自然灾害暴露情况不知情的研究者摘录。有关饥荒年出生人数和死亡人数的数据是有效可用的,累积死亡率根据以后的人口学调查进行估计。
主要观测指标:饥荒的证据已经核实,计算未校正的以及对死亡率进行校正后的发生精神分裂症的相对危险度。
结果:安徽省的出生率(每1000人)在饥荒期问降低了约80%,从1958年的28.28降至1959年的20.97、1960年的8.61和1961年的11.06。在饥荒期间出生的人,晚年发生精神分裂症的校正后危险明显增高,从1959年的0.84%增至1960年的2.15%和1961年的1.81%。死亡率校正相对危险在1960年出生者为2.30(95%可信区间,1.99~2.05),1961年出生者为1.93(95%可信区间,1.68~2.23)。
结论:我们的调查重复了荷兰不同种族人群的数据,结果显示,出生前遭受饥荒可增高晚年患精神分裂症的危险。 | David St Clair Mingqing Xu Peng Wang Yaqin Yu Yourong Fang Feng Zhang Xiaoying Zheng Niufan Gu Guoyin Feng Pak Sham Lin He 张继志(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 3 |
| 2 | Targeting head and neck tumoral stem cells: From biologicalaspects to therapeutic perspectives显示文摘Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities. | Benoîte Méry Jean-Baptiste Guy Sophie Espenel Anne-Sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，1： | 3 |
| 3 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 4 | Laparoscopic resection of hepatocellular carcinoma: a F rench survey in 351 patients显示文摘 | Olivier Soubrane Claire Goumard Alexis Laurent Hadrien Tranchart Stéphanie Truant Brice Gayet Chadi Salloum Guillaume Luc Safi Dokmak Tullio Piardi Daniel Cherqui Ibrahim Dagher Emmanuel Boleslawski Eric Vibert Antonio Sa Cunha Jacques Belghiti Patrick Pe | 2014 | HPB2014，，4： | 2 |
| 5 | 在亚洲和欧洲人群中对一个AC二核苷酸重复的多态性位点与精神分裂症的关联研究显示文摘连锁研究表明,染色体15q13-q14区域可能是精神分裂症的易感区域。在此项研究中,使用来自中国和苏格兰的3套独立的样本,对位于D15S118的AC二核苷酸重复的多态性位点与精神分裂症进行了关联分析。在苏格兰病例-对照样本中,该多态性位点的等位基因在患者和正常人中的分布存在显著性差异(P=0.04),但是这一结果在中国的病例-对照组中没有得到重复。在中国三口之家的样本中,我们没有观察到有等位基因从正常的父母向患病子女的传递不平衡。总之,至少在中国人中,此结果不支持这个AC二核苷酸重复的多态性位点在精神分裂症的易感性中扮演重要的角色。后续的研究有必要进一步阐明在欧洲人中该多态性位点在精神分裂症的易感性中扮演的角色。 | 马捷 樊金波 吴胜男 张长顺 纪宝虎 王磊 李兴旺 顾牛范 冯国鄞 David St Clair 贺林 | 2007 | 遗传2007，29，10： | 2 |
| 6 | Wet spinning of solid pnlyamic acid fibers显示文摘 | William E Dorogy Jr Anne K ST Clair | 1991 | Journal of Applied Polym Science1991，43，3： | 1 |
| 7 | Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133显示文摘 | Shmelkov SV Jun L St Clair R | 2004 | Blood2004，103，6： | 1 |
| 8 | Oblique lumbar interbody fixation:a biomeehanieal study in human spines 显示文摘 | St Clair S Tan JS Lieberman I | 2012 | J Spinal Disord Teeh2012，25，4： | 1 |
| 9 | CTLA4Ig: Bridging the basic immunology with clinical application 显示文摘 | Bluestone JA St Clair EW Turka LA | 2006 | Immunity2006，24，3： | 1 |
| 10 | Infliximab and methotrexate in the treatment of rheumatoid arthritis显示文摘 | Lipsky P E Van der Heijde D M St clair E W | 2000 | N Eng J Med2000，343，： | 1 |
| 11 | Infliximab treatment for rheumatic disease: clinical and radiological efficacy显示文摘 | St Clair EW | 2002 | Ann Rheum Dis2002，61，2： | 1 |
| 12 | Hepatitis C virus-related cryoglobulinemic vas-culitis:emerging trends in therapy显示文摘 | St Clair EW | | 0，，03： | 1 |
| 13 | Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophagns显示文摘 | Zhao B Song J St Clair RW | 2007 | Am J Physiol Cell Physiol2007，292，1： | 1 |
| 14 | Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies显示文摘 | Haynes BF Fleming J St Clair EW | 2005 | Science2005，308，5730： | 1 |
| 15 | AC133/CD133/Prominin-1显示文摘 | SHMELKOV S V st CLAIR R LYDEN D | 2005 | Int Biochem Cell Biol2005，37，4： | 1 |
| 16 | Infliximab (chimeric anti-tumor necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomized phase Ⅲ trail 显示文摘 | Maini R St Clair EW Breedveld F | 1999 | Lancet1999，354，9194： | 1 |
| 17 | Association within a family of a valanced autosomal translocation with major mental illness 显示文摘 | St Clair D Blackwood D Evans H J | 1990 | Lancet1990，336，8706： | 1 |
| 18 | A NADPH oxi- dase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells显示文摘 | Sun Y St Clair DK Xu Y | 2010 | Cancer Res2010，70，7： | 1 |
| 19 | Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133显示文摘 | KOV S V JUN L st CLAIR R | 2004 | Blood2004，103，6： | 1 |
| 20 | Blocking transition prevents p53 mitochondrial translocation during skin tumor promotion 显示文摘 | LIU J ST CLAIR D K mitochondrial permeability GU X | 2008 | FEBS Letters2008，582，9： | 1 |
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