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| 1 | Distribution and risk factors of hand, foot, and mouth disease in Changchun, northeastern China显示文摘Hand,foot,and mouth disease(HFMD)is a public health problem,and there have been increasing numbers of outbreaks in China's Mainland since 2008.Over17,000 HFMD cases have been reported in Changchun between 2008 and 2011.This study characterized the temporal and spatial distribution of the disease and identified the risk factors for HFMD.The main findings were as follows:(i)there were significant differences in HFMD incidence among age groups,with 86.8%of reported cases in children younger than 5 years old,and boys showed a higher incidence than girls(\6 years);(ii)The disease affected the whole region and spanned a large geographic area,but there was a higher incidence in urban areas(median=242 per 10,000 persons)and urban–rural border areas(median=135 per 10,000 persons),compared with rural areas(median=75 per 10,000 persons);and(iii)the incidence of HFMD in Changchun was significantly associated with the distance to the nearest freeway,GDP per capita,and the type of township. | Li Yan Xinlou Li Yaqin Yu Sake J.de Vlas Yapin Li Dandan Wang Yanli Li Yuan Yin Jing Wu Hong Liu Hong Yang Bo Li Liqun Fang Wuchun Cao | 2014 | Chinese Science Bulletin2014，59，5： | 7 |
| 2 | Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model显示文摘Chaperone-mediated autophagy(CMA)is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases.However,the mechanisms that regulate CMA are not fully understood.Here,using unbiased drug screening approaches,we discover Metformin,a drug that is commonly the first medication prescribed for type 2 diabetes,can induce CMA.We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKα/β signaling that leads to phosphorylation of Ser85 of the key mediator of CMA,Hsc70,and its activation.Notably,we find that amyloid-beta precursor protein(APP)is a CMA substrate and that it binds to Hsc70 in an IKKα/β-dependent manner.The inhibition of CMA-mediated degradation of APP enhances its cytotoxicity.Importantly,we find that in the APP/PS1 mouse model of Alzheimer's disease(AD),activation of CMA by Hsc70 overexpression or Metformin potently reduces the accumulated brain Aβplaque levels and reverses the molecular and behavioral AD phenotypes.Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKα/β-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases,such as AD,where such therapeutic intervention could be beneficial. | Xiaoyan Xu Yaqin Sun Xufeng Cen Bing Shan Qingwei Zhao Tingxue Xie Zhe Wang Tingjun Hou Yu Xue Mengmeng Zhang Di Peng Qiming Sun Cong Yi Ayaz Najafov Hongguang Xia | 2021 | Protein & Cell2021，12，10： | 5 |
| 3 | Extraction and purification of the polysaccharides in Hippohaere rhamnoides L.显示文摘The different extraction technology and purification technology of Hippohpae rhamoides polysaccharides were researched in the paper.The best method of papain extraction were obtained,the ratio of papain 2%,pH at 5.5,temperature at 45℃and extraction time of 20 min were suitable for papain extraction.The highest content of Hippohpae rhamoides polysaccharides was 44.28 mg·g^(-1). The optimum process of ultrasonic extraction were obtained,namely extracted for 55 min at 480 W with the material ratio of 1:20. The highest content of Hippohpae rhamoides polysaccharides was 48.63 mg·g^(-1).The results showed that the ultrasonic and papain extraction together was the best method,the content was 54.30 mg·g^(-1).After the removing protein,pigment and dialysis.Two fraction were separated from the purified Hippohpae rhamoides by DEAE-cellulose chromatography,the main fraction was collected finally. The fraction was identified by Sepharose CL-4B gel filtration.Ultraviolet spectrometry,freeze-thawing analysis showed that fraction was purified.Its molecular weight was probably 109.4 ku. | XU Yaqin JIN Ting YU Zeyuan FU Hong | 2007 | Journal of Northeast Agricultural University(English Edition)2007，14，2： | 3 |
| 4 | 胎儿期恰逢1959~1961年饥荒的中国成人精神分裂症的发病率显示文摘背景:精神分裂症是一种常见的中度精神障碍。子宫内营养缺乏可增大患精神分裂症的危险。其主要依据来自1944~1945年荷兰饥饿冬天(Dutch Hunger Winter)研究,当时食品摄入在短期内极剧下降。这项有关饥荒期间受孕人群的大型队列研究显示,发生精神分裂症的危险增大两倍。
目的:确定经受1959~1961年大饥荒的中国人是否有相似的结果。
设计、地点及参试者:发生精神分裂症危险的调查于安徽省芜湖地区进行,这是当初受灾最重的地区之一。对饥荒之前、饥荒期间和饥荒以后出生的人群发病率进行比较。芜湖及其周围6个县是由一所精神病院负责的。对1971~2001年所有的精神病病历记录均进行检查。精神分裂症患者的临床和社会人口学资料由对自然灾害暴露情况不知情的研究者摘录。有关饥荒年出生人数和死亡人数的数据是有效可用的,累积死亡率根据以后的人口学调查进行估计。
主要观测指标:饥荒的证据已经核实,计算未校正的以及对死亡率进行校正后的发生精神分裂症的相对危险度。
结果:安徽省的出生率(每1000人)在饥荒期问降低了约80%,从1958年的28.28降至1959年的20.97、1960年的8.61和1961年的11.06。在饥荒期间出生的人,晚年发生精神分裂症的校正后危险明显增高,从1959年的0.84%增至1960年的2.15%和1961年的1.81%。死亡率校正相对危险在1960年出生者为2.30(95%可信区间,1.99~2.05),1961年出生者为1.93(95%可信区间,1.68~2.23)。
结论:我们的调查重复了荷兰不同种族人群的数据,结果显示,出生前遭受饥荒可增高晚年患精神分裂症的危险。 | David St Clair Mingqing Xu Peng Wang Yaqin Yu Yourong Fang Feng Zhang Xiaoying Zheng Niufan Gu Guoyin Feng Pak Sham Lin He 张继志(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 3 |
| 5 | The flexural property and its synergistic mechanism of multibody molded beetle elytron plates显示文摘To improve the applications of beetle elytron plates(BEPs,which are biomimetic sandwich plates inspired by beetle elytra),the flexural performance and its synergistic mechanism of multibody molded BEPs were investigated via cantilever testing and finite element method(FEM).The results are summarized as follows.(1)Although debonding damage causes failure of the multibody molded BEPs and honeycomb plate and the reasonable range of trabecular size for BEPs is narrow,both the optimal loading capacity per mass and failure deformation of the BEPs are over two times those of the honeycomb plate.(2)A flexural synergistic mechanism is revealed in the trabecular-honeycomb core structure of BEPs;this mechanism causes the maximum deformation of core structure to gradually transfer from the honeycomb wall to the trabeculae with the increase inη(the ratio of the trabecular radius to the distance between the center points of two trabeculae),which means the different stretching behaviors in these core structures.(3)Unlike the compressive mechanism of BEPs,by controlling and balancing the deformation degrees of the trabeculae and honeycomb walls,the flexural mechanism achieves a minimum core deformation and an optimal flexural performance.These results suggest a qualitative relationship between the deformation behavior of trabecular-honeycomb core structure and bending performance of the whole BEP,and provide a solid foundation for subsequent research and the considerable application potential of this biomimetic sandwich structure in many fields. | YU XinDi ZHANG XiaoMing CHEN JinXiang ZHAO CaiQi ZHAO TiDong FU YaQin | 2020 | Science China(Technological Sciences)2020，63，5： | 2 |
| 6 | A scalable bio-inspired polydopamine-Cu ion interfacial layer for high-performance lithium metal anode显示文摘The growth of Li dendrites and the instability of the solid electrolyte in terphase(SEI)layer during plating/stripping has hin dered the practical applicati on of high-energy-density batteries based on a lithium metal anode.Building a stable interfacial layer is effective in preventing lithium corrosiion by the electrolyte and controlling the deposition of lithium metal.Here,we present a robust polydopamine-Cu ion(PDA-Cu^2+)coati ng layer formed by the aggregation of nanoparticles and Cu ions,which can be obtained by a subtle immersion strategy.We demonstrate that the PDA-Cu^2+ protective layer,with a unique structure comprising nanoparticles,can regulate and guide Li metal deposition,and together with Cu ions,forms a lubricating surface to facilitate uniform Li ion diffusion and induce stable SEI layer formation.Li anodes with this PDA-Cu^2+layer modification ultimately achieve higher Coulombic efficiencies,which are consistently stable for over 650 cycles at 0.5 mA·cm^-2 without Li dendrites.The introduced PDA-Cu^2+ coating can adhere to any material of any shape;addition ally,the operation can be realized on a large scale because of its simplicity.These merits provide a promising approach for developing stable and safe lithium metal batteries. | Qianqian Meng Huimin Zhang Yue Liu Shaobo Huang Tianzhu Zhou Xiaofei Yang Biyan Wang Wenfeng Zhang Hai Ming Yu Xiang Meng Li Gaoping Cao Yaqin Huang Li-zhen Fan Hao Zhang Yuepeng Guan | 2019 | Nano Research2019，12，12： | 2 |
| 7 | Architecture,Key Technologies and Applications of Load Dispatching in China Power Grid显示文摘With the development of renewable energy and the changes in the characteristics of power grid,it is becoming increasingly difficult to balance power supply and demand in space and time.In addition,the requirement for improved dispatching capability of power grid is increasing.Therefore,the potential of flexible load dispatching should be realized,which can promote the large-scale consumption of renewable energy and the construction of new power grid.Based on the analysis of existing load dispatching studies and the differences in the characteristics of domestic and foreign load dispatchings,a technical architecture and several key technologies are proposed for load resources to participate in power grid dispatching under the new situation,i.e.,the autonomous collaborative control system of load dispatching.This system implements the multi-layer coordinated control of main,distribution and micro grids(load aggregators).Adjustable load resources are aggregated through an aggregator operation platform and connected with a dispatcher load regulator platform to realize real-time data interaction with dispatching agencies as well as the monitoring,con-trol,and marketing of aggregators.It supports the load resources to participate in network-wide dispatching optimization via continuous power adjustment.Several key technologies such as the control mode,load modeling,dispatching strategy,and safety protection are also elaborated.Through the closed-loop control of orderly charging piles and energy storage clusters in the North China Power Grid,the feasibility of the proposed architecture and key technologies is verified.This route has successively supported multiple adjustable load aggregators to partici-pate in the ancillary services market of North China Power Grid for peak-shaving.Finally,the technical challenges of load resources participating in power grid dispatching under the dual carbon goals are discussed and prospected. | Yu Dong Xin Shan Yaqin Yan Xiwu Leng Yi Wang | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，2： | 2 |
| 8 | Functional analysis of a novel βV1 gene identified in a geminivirus betasatellite显示文摘Betasatellites(DNAβ)are circular ssDNA molecules that are associated with monopartite geminiviruses and exert a positive effect on the viral infection.Betasatellites encode one protein,namedβC1,on the complementary strand;βC1 functions as a pathogenicity factor and RNA silencing suppressor.In this report,we describe the identification of another betasatellite-encoded protein,βV1,which also contributes to symptom development.TheβV1 open reading frame can be found on the viral strand of approximately 40%of reported betasatellite sequences,and is conserved in position and sequence.The presence of theβV1 transcript was observed in plants infected with Tomato yellow leaf curl China virus(TYLCCNV)along with its associated betasatellite Tomato yellow leaf curl China betasatellite(TYLCCNB).Mutant viruses unable to produceβV1 showed reduced virulence and decreased viral load.Ectopic expression of the TYLCCNB-βV1 gene in Nicotiana benthamiana plants from a PVX-based vector resulted in leaf mosaic and chlorosis.We further demonstrated that theβV1 protein could elicit hypersensitive response(HR)-type cell death in N.benthamiana leaves.Our results uncover a novel betasatellite-encoded protein that contributes to the virus infection,and this discover gives us a more complete view of the plant-geminivirus interaction landscape. | Tao Hu Yu Song Yaqin Wang Xueping Zhou | 2020 | Science China(Life Sciences)2020，63，5： | 2 |
| 9 | Highly stableβ‑ketoenamine‑based covalent organic frameworks(COFs):synthesis and optoelectrical applications显示文摘Covalent organic frameworks(COFs)are one class of porous materials with permanent porosity and regular channels,and have a covalent bond structure.Due to their interesting characteristics,COFs have exhibited diverse potential applications in many felds.However,some applications require the frameworks to possess high structural stability,excellent crystallinity,and suitable pore size.COFs based onβ-ketoenamine and imines are prepared through the irreversible enol-to-keto tautomerization.These materials have high crystallinity and exhibit high stability in boiling water,with strong resistance to acids and bases,resulting in various possible applications.In this review,we frst summarize the preparation methods for COFs based onβ-ketoenamine,in the form of powders,flms and foams.Then,the efects of diferent synthetic methods on the crystallinity and pore structure of COFs based onβ-ketoenamine are analyzed and compared.The relationship between structures and diferent applications including fuorescence sensors,energy storage,photocatalysis,electrocatalysis,batteries and proton conduction are carefully summarized.Finally,the potential applications,large-scale industrial preparation and challenges in the future are presented. | Yaqin Li Maosong Liu Jinjun Wu Junbo Li Xianglin Yu Qichun Zhang | 2022 | Frontiers of Optoelectronics2022，15，3： | 2 |
| 10 | Sequence determination and anticoagulant and antithrombotic activities of a novel sulfated fucan isolated from the sea cucumber Isostichopus badionotus显示文摘 | Shiguo Chen Yaqin Hu Xinqian Ye Guoyun Li Guangli Yu Changhu Xue Wengang Chai | 2012 | BBA - General Subjects2012，，7： | 1 |
| 11 | Magnetic and electrically conductive epoxy/graphene/earbonyl iron nanocomposites for efficient electromagnetic interference shielding显示文摘 | Yu Chen Hao-Bin Zhang Yaqin Huang etc | 2015 | Composites Science and Technology2015，，： | 1 |
| 12 | Preparation,model construction and efficacy lipid-lowering evaluation of kiwifruit juice fermented by probiotics显示文摘In this study,kiwi juice was fermented with acid-resistant and bile-resistant probiotics to screen out lactic acid bacteria that can lower cholesterol and were suitable for kiwi fermentation.A non-linear fitting equation was used to establish a kinetic model of probiotics fermenting kiwi juice(R^(2)>0.90),and then a fermented juice with special effects of lowering fat was prepared.We have studied the lipid-lowering effect of fermented fruit juice through in vivo validation experiments in mice,and determined the lipid-lowering effect of fermented fruit juice according to the mouse serum indicators and the distribution of intestinal flora.The results suggested that the juice fermented with Bifidobacterium bifidum 6169 and Lactobacillus plantarum 21805 were more effective in cholesterol degradation,and the cholesterol degradation rates were 67.57%and 64.22%,respectively.The number of viable bacteria after fermentation was significantly higher than other groups(p<0.05),and the sensory score was also higher.In addition,the serum indicators were significantly ameliorated and the number of beneficial microorganisms in the intestinal flora increased after the high-fat mice were treated with fermented kiwifruit juice.The research indicates that the fermented products have a regulatory effect on cholesterol levels in mice with hyperlipidemia. | Yu Wang Hongcai Li Yichen Ren Yaqin Wang Ren Yaopeng Wang Xiaowei Yue Tianli Wang Zhouli Gao Zhenpeng | 2022 | Food Bioscience2022，47，3： | 1 |
| 13 | Research on the characteristics of red mud granular adsorbents ( RM- GA) for phosphate removal 显示文摘 | Qinyan Yue Yaqin Zhao Qian Li Wenhong Li Baoyu Gao Shuxin Han Yuanfeng Qi Hui Yu | 2010 | Journal of Hazardous Materials2010，，176： | 1 |
| 14 | Simultaneous voltammetric determination for DA, AA and NO2 based on grapheme/poly- cyclodextrin/MWCNTs nanocomposite platform 显示文摘 | Zhang Yu Yuan Ruo Chai Yaqin | 2011 | Biosensors and bioelectronics2011，26，： | 1 |
| 15 | Optimization of nobiletin extraction assisted by microwave from orange byproduct using response surface methodology显示文摘 | Yu Zhang Hongjun Li Huating Dou Zhifei He Houjiu Wu Zhigao Sun Hua Wang Xuegen Huang Yaqin Ma | 2013 | Food Science and Biotechnology2013，，1： | 1 |
| 16 | Optical frequency synthesizer referenced to an ytterbium optical clock显示文摘Optical clocks with an unprecedented accuracy of 10-18 promise innovations in precision spectroscopy and measurement. To harness the full power of optical clocks, we need optical frequency synthesizers(OFSs) to accurately convert the stabilities and accuracies of optical clocks to other desired frequencies. This work demonstrates such an OFS referenced to an ytterbium optical clock. The OFS is based on an optical frequency comb phase-locked to a commercial rubidium microwave clock;in this way most combs can operate robustly. Despite comb frequency instability at 10^(-11), the synthesis noise and uncertainty reach 6 × 10^(-18)(1 s) and 5 × 10^(-21), respectively, facilitating frequency synthesis of the best optical clocks. In the OFS, the coherence of the OFS internal oscillator at 1064 nm is accurately transferred to a 578 nm laser for resolving the hertz-level-linewidth ytterbium clock transition(unaffected by megahertz-linewidth comb lines) and faithfully referencing the OFS to an ytterbium optical clock. | YUAN YAO BO LI GUANG YANG XIAOTONG CHEN YAQIN HAO HONGFU YU YANYI JIANG LONGSHENG MA | 2021 | Photonics Research2021，9，2： | 1 |
| 17 | Spectroscopic properties of Er3+ ions and ErP5O14 crystals 显示文摘 | Su Qiang Wang Qingyuan Yu Yaqin | 1986 | Chinese Physics Laser1986，13，11： | 1 |
| 18 | Spatial pattern of macrobenthic communities along a shelf-slope-basin transect across the Bering Sea显示文摘Due to its unique geological location, the Bering Sea is an ideal place to investigate the water exchange and ecosystem connectivity of the Pacific Ocean–Arctic Ocean and subarctic–Arctic region. Based on a number of summer surveys(July to September, 2010, 2012 and 2014), macrobenthic communities and their spatial-temporal patterns are exhibited for the majority of the Bering Sea(53°59′–64°36′N). The results show that the macrobenthic communities were dominated by northern cold-water species and immigrant eurythermic species, and the communities assumed a dispersed and patchy distribution pattern. Polychaetes(Scoloplos armiger), crustaceans(Ceradocus capensis) and sea urchins(Echinarachnius parma) were the main dominant groups in the shallow shelves; the sea star(Ctenodiscus crispatus) and the brittle star(Ophiura sarsii) were the main dominant groups in the continental slope; whereas small polychaetes(Prionospio malmgreni) dominated the basin area. Sediment type, water depth, and currents were the major factors affecting the structure and spatial distribution of the macrobenthic communities. Compared with other seas, the shallow areas of the Bering Sea showed an extremely high-standing biomass. In particular, the northern shelf area(north of St. Lawrence Islands and west of 170°W),which is primarily controlled by Anadyr Water, is an undersea oasis. In contrast, a deficiency in the downward transport of particulate organic carbon has resulted in a desert-like seabed in the basin area. By comparing our results to previous studies, we found that macrobenthic communities of the Bering Sea have undergone significant structural changes in recent decades, resulting in a decrease in abundance and an increase in biomass.In addition, populations of amphipods and bivalves in the northern shelves have decreased significantly and have been gradually replaced by other species. These changes might be associated with advanced seasonal ice melting,changes in organic carbon input, and global warming, indicating that large-scale ecosystem changes have been occurring in the Bering Sea. | LIN Heshan LIU Kun WANG Jianjun HUANG Yaqin LI Zhong LIN Junhui HE Xuebao ZHANG Shuyi MOU Jianfeng WANG Yu XING Bingpeng | 2018 | Acta Oceanologica Sinica2018，37，6： | 1 |
| 19 | The effect of different Fe 2+ concentrations in culture media on the recycling of ground tyre rubber by Acidithiobacillus ferrooxidans YT-1显示文摘 | Yuanhu Li Suhe Zhao Liqun Zhang Yaqin Wang Wangyang Yu | 2013 | Annals of Microbiology2013，，1： | 1 |
| 20 | Sequence determination and anticoagulant and antithrombotic activities of a novel sulfated fucan isolated from the sea cucumber Isostichopus badionotus显示文摘 | Shiguo Chen Yaqin Hu Xinqian Ye Guoyun Li Guangli Yu Changhu Xue Wengang Chai | 2012 | BBA - General Subjects2012，，7： | 1 |
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