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| 1 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 2 | Performance of tunnel support under large deformation static and dynamic loading显示文摘 | ORTLEPP W D STACEY T R | 1998 | Tunnelling and Underground Space Technology1998，13，1： | 1 |
| 3 | A Kalman filter clock algorithm for use in the presence of flicker frequency modulation noise显示文摘 | Davis J A Greenhall C A Stacey P W | 2005 | Metrologia2005，42，1： | 1 |
| 4 | Simulations of the wind-forced near-surface circulation in Knight Inlet:A parameteriza- tion of the roughness length显示文摘 | STACEY M W | 1999 | J Phys Oceanogr1999，29，： | 1 |
| 5 | Biological variation for N-terminal pro-and B-type natriuretic peptides and implications for therapertic monitoring of patients with congestive heart failure显示文摘 | AlanHB Andrew S Stacey W | 2003 | Am J Cardiol2003，92，5： | 1 |
| 6 | Nuclear and fuel cycle analysis for a fusion transmutation of waste reactor 显示文摘 | Hoffman E A Stacey W M | 2002 | Fusion Eng Design2002，6364，： | 1 |
| 7 | Performance of tunnel support under large deformation,static and dynamic loading显示文摘 | ORTLEPP W D STACEY T R | 1998 | Tunnelling and Underground Space Technology1998，13，1： | 1 |
| 8 | Rockburst mechanisms in tunnels and shafts 显示文摘 | Ortlepp W D Stacey T R | 1994 | Tunneling and Underground Space Technology1994，9，1： | 1 |
| 9 | Transmutation missions for fusion neutron sources显示文摘 | Stacey W M | 2007 | Fusion Eng Design2007，82，： | 1 |
| 10 | Biodegradation of Rhamnolipid, EDTA and Citric Acid in Cadmium and Zinc Con- taminated Soils 显示文摘 | JIA W STACEY S P MCLAUGHLIN M J | 2009 | Soil Biology and Biochemistry2009，41，10： | 1 |
| 11 | A Kalman filter clock algorithm for use in the presence of flicker frequency modulation noise显示文摘 | Davis J A Greenhall C A Stacey P W | 2005 | Metrologia2005，42，1： | 1 |
| 12 | Monitoring science andtechnology for competitive Advantage 显示文摘 | Ashton W B Johnson A H Stacey G S | 1994 | Competitive Intelligence Review1994，5，1： | 1 |
| 13 | A Tokamak Tritium Production Reactor 显示文摘 | Favorite J A Belanger M J | 1997 | Fusion Technology1997，，： | 1 |
| 14 | A new phantom material employing depolymerised natural rubber 显示文摘 | STACEY A J BEVAN A R DICKENS C W | 1961 | Br J Radiol1961，34，： | 1 |
| 15 | A Tokamak Tritium Production Reactor Design Ⅱ 显示文摘 | Aldridge J P | 1998 | Fusion Technology1998，，： | 1 |
| 16 | Rockburst mechanisms in tunnels and shafts显示文摘 | Ortlepp W D Stacey T R | 1994 | Tunnelling and Underground Space Technology1994，9，1： | 1 |
| 17 | Performance of tunnel support under large deformation static and dynamic loading显示文摘 | ORTLEPP W D STACEY TR | 1998 | Tunneling and Underground Space Technology1998，13，1： | 1 |
| 18 | Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells显示文摘 | Stacey D W | 2003 | Curr Opin Cell Biol2003，15，： | 1 |
| 19 | The Arabidopsis AtOPT3 protein functions in metal homeostasis and movement of iron to developing seeds 显示文摘 | Stacey M G Patel A McClain W E | 2008 | Plant Physiology2008，146，2： | 1 |
| 20 | Minireview: inhibin binding protein (INHBP120/p120), betaglycan, and the continuing search for the inhibin receptor显示文摘 | DANIEL J B STACEY C C TERESA K W | 2002 | Mol Endocrinol2002，16，2： | 1 |
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