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| 1 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 2 | Determination of acyclovir in maternal plasma, amniotic fluid,fetal and placental tissues by high-performance liquid chromatography 显示文摘 | STACY D BROWN CATHERINE A WHITE CHUNG K CHU | 2002 | Journal of Chromatography B2002，772，： | 1 |
| 3 | Bariatric surgery for type 2diabetes:weighing the impact for obesepatients显示文摘 | Sangeeta R Patrick A Stacy B | 2010 | Cleve Clin J Med2010，7，777： | 1 |
| 4 | A per oxiredoxin antioxidant is encoded by a dormancy related gene,Perl , expressed during late development in the aleu rone and embryo of barley grains显示文摘 | Robin A P Stacy Else Munthe Terie Steinum | 1996 | Plant Molecular Biology1996，31，： | 1 |
| 5 | The Russel - Yasuda Kasai model : an asset/liability model for a Japanese insurance company using multi - stage stochastic programming 显示文摘 | Carino D R Kent T Mayers D H Stacy C Sylvanus M Turner A Watanabe K Ziemba W T | 1994 | Interfaces1994，24，： | 1 |
| 6 | Inheritance of dollar spot resistance in creeping bentgrass显示文摘 | Stacy A B Michael D C William A M | 2003 | Crop Science2003，43，6： | 1 |
| 7 | Biomimetic synthesis of calcium-deficient hydroxyapatite in a natural hydrogel显示文摘 | Stacy A Hutchens Roberto S | | 0，，26： | 1 |
| 8 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 9 | Electrical characterization of aluminum nitride films on silicon grown by chemical vapor deposition 显示文摘 | Khan A H Messe J M Stacy T | 1994 | Mat Res Soc Symp Proc1994，339，： | 1 |
| 10 | Structural comparison of cognitive associative networks in two populations 显示文摘 | Coronges K Stacy A Valente T | 2007 | Journal of Applied Social Psychology2007，37，9： | 1 |
| 11 | Pulsed laser dep- osition of skutterudite thin films显示文摘 | Caylor J C Stacy A M Gronsky R | 2001 | Journal of Applied Physics2001，89，6： | 1 |
| 12 | Building agent teams using an explicit teamwork model and learning显示文摘 | Milind Tambe Jafar Adibi Yaser Al-Onaizan Ali Erdem Gal A Kaminka Stacy C Marsella Ion Muslea | 1999 | Artificial Intelligence1999，110，4： | 1 |
| 13 | Differential regulation of the barley (Hordeum ulgare) transcripts B22E and B12D in mature aleurone layers 显示文摘 | STEINUM T M BERNER H S STACY R A P | 1998 | Plant Physiology1998，，102： | 1 |
| 14 | The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity显示文摘 | Beck Stacy Wojdyla Daniel Say Lale Betran Ana Pilar Merialdi Mario Requejo Jennifer Harris Rubens Craig Menon Ramkumar Van Look Paul F A | 2010 | Bulletin of the World Health Organization2010，，1： | 1 |
| 15 | Complexed prostate-specific antigen as a staging tool: results based on a multicenter prospective evaluation of complexed prostate-specific antigen in cancer diagnosis显示文摘 | Samir S Taneja Elias I Hsu Carol D Cheli Paul Walden Georg Bartsch Wolfgang Horninger Richard J Babaian Herbert A Fritsche Stacy Childs Thomas A Stamey Lori J Sokoll Daniel W Chan Michael K Brawer Alan W Partin Herbert Lepor | 2002 | Urology2002，，4： | 1 |
| 16 | Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity显示文摘 | Suzuki Hitoshi Fan Run Zhang Zhixin Brown Rhubell Hall Stacy Julian Bruce A Chatham W Winn Suzuki Yusuke Wyatt Robert J Moldoveanu Zina Lee Jeannette Y Robinson James Tomana Milan Tomino Yasuhiko Mestecky Jiri Novak Jan | 2009 | Journal of Clinical Investigation2009，，6： | 1 |
| 17 | Electrodeposited bismuth telluride nanowire arrays with uniform growth fronts 显示文摘 | Trahey L Becker C R Stacy A M | 2007 | Nano Lett2007，7，： | 1 |
| 18 | Evaluation of Drought Resistance for Texas Blue grass, KentuCKy Bluegrass, and Their Hybride 显示文摘 | Eleni M Abraham Bingru t-Iuang Stacy A Bonos | 2004 | Crop Science2004，44，5： | 1 |
| 19 | Estrogen receptorα andβExpression in theca and granulosa cells from women with polycystic ovary syndrome显示文摘 | Artur J J Stacy R W Denis A N | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 20 | The Russel - Yasuda Kasai model: an asset/liability model for a Japanese insurance company using multi - stage stochastic programming 显示文摘 | Carino D R Kent T Mayers D H Stacy C Sylvanus M Turner A Watanabe K Ziemba W T | 1994 | Interfaces1994，，24： | 1 |
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