| 1 | Clostridium novyi-NT in cancer therapy显示文摘The attenuated anaerobic bacterium Clostridium novyi-NT(C.novyi-NT)is known for its ability to precisely germinate in and eradicate treatment-resistant hypoxic tumors in various experimental animal models and spontaneously occurring canine sarcomas.In this article,we review the therapeutic and toxicologic aspects of C.novyi-NT therapy,key challenges and limitations,and promising strategies to optimize its performance via recombinant DNA technology and immunotherapeutic approaches,to establish C.novyi-NT as an essential tool in cancer therapy. | Verena Staedtke Nicholas J.Roberts Ren-Yuan Bai Shibin Zhou | 2016 | Genes & Diseases2016，3，2： | 1 |
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