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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | New antimalarial targets: the example of glucose transport显示文摘 | Patel A P Staines H M Krishna S | 2008 | Travel Med Infect Dis2008，6，12： | 1 |
| 3 | Preparation and certification of Re-Os dating reference materials:Molybdenite HIP and JDC显示文摘 | Du A Wu S Sun D Wang S Qu W Markey R Stain H Morgan J Malinovskiy D | 2004 | Geostandard and Geoanalytical Research2004，28，1： | 1 |
| 4 | Characterization of a pollen-expressed gene encoding a putative pectin esterase of Petunia inflata显示文摘 | Mu J H Stains J P Kao T | 1994 | Plant Mol Siol1994，，3： | 1 |
| 5 | Preparation and certification of Re-Os dating reference materials:Molybdenite HLP and JDC显示文摘 | Du A Wu S Sun D Wang S Qu W Markey R Stain H Morgan J Malinovskiy D | 2004 | Geostandard and Geoanalytical Research2004，28，1： | 1 |
| 6 | Chitinase and laminarinase production in liquid culture by Trichoderma spp and their role in biocontrol of wood decay fungi 显示文摘 | Srinivasam U Staines H J | 1995 | International Biodeterioration & Biodegradation1995，，： | 1 |
| 7 | Systematic assessment of massive bleeding of the lower part of the gastrointestinal tract 显示文摘 | STAIN S C GILG M | 1992 | Surg Gynecol Obstel1992，175，6： | 1 |
| 8 | Characterization of a pollenexpressed gene encoding a putative pectin esterase of petunia inflate显示文摘 | MU J H STAINS J P KAO T | | Plant Mol Biol0，25，3： | 1 |
| 9 | Preparation and certification of Re-Os dating reference materials:Molybdenite HLP and JDC显示文摘 | Du A D Wu S Q Sun D Z Wang S X Qu W J Markey R Stain H Morgan J Malinovskiy D | 2004 | Geostandard and Geoanalytical Research2004，28，1： | 1 |
| 10 | Preparation and certification of Re-Os dating reference materials: Molybdenites HLP and JDC显示文摘 | Du A D Wu S Q Sun D Z Wang S X Qu W J Markey R Stain H Morgan J Malinovskiy D | 2004 | Geostand Geoanal Res2004，28，1： | 1 |
| 11 | Managerial competence insmall firms显示文摘 | MARTIN G STAINES H | 1994 | Journal of Management Development1994，13，1： | 1 |
| 12 | Preparation and certification of Re-Os dating reference materials: Molybdenites HLP and JDC 显示文摘 | Du A D Wu S Q Sun D Z Wang S X Qu w J Markey R Stain H Morgan J Malinovskiy D | 2004 | Geostandards and Geoanalytical Research2004，28，1： | 1 |
| 13 | B-type natriuretic peptide is a long-term predictor of all-cause mortality,whereas highsensitive C-reactive protein predicts recurrent short-term troponin T positive cardiac events in chest pain patients:a prognostic study显示文摘 | Brugger-Andersen T Ponitz V Staines H | 2008 | BMC Cardiovasc Disord2008，8，： | 1 |
| 14 | Distributed fiber temperature and strain sensor using coherent radio-frequency detection of spontaneous Brillouin scattering 显示文摘 | Geng J H Staines S Blake M | 2007 | Applied Optics2007，46，5： | 1 |
| 15 | You feel helpless that's exactly it: Parentg and young people beliefs about bed-wetting and the implica- tions for praetiee显示文摘 | Morrison MJ Tappin D Staines H | 2000 | Adr Nurs2000，31，5： | 1 |
| 16 | Application to surgical and experimental neurooncology显示文摘 | Plate K H Ruschoff J Mennel H D Cell proliferation in intra cranial tumors: selective silve staining of nucleolar organizer regions(AgNOR) | 1991 | Neuropathol Appl Neurobiol1991，17，2： | 1 |
| 17 | Exploring the Relationship between Psychological Contracts and Organizational Change:A Process Study Evidence显示文摘 | Pate J Martin G Staines H | | 0，，08： | 1 |
| 18 | Preparation and certification of Re-Os dating reference materials:Molybdenite HLP and JDC显示文摘 | Du A Wu S Sun D Wang S Qu W Markey R Stain H Morgan J Malinovskiy D | 2004 | Gestandard and Geoanalytical Research2004，28，1： | 1 |
| 19 | Preparation and certification of Re-Os dating reference materials:Molybdenite HLP and JDC显示文摘 | Du A Wu S Sun D Wang S Qu W Markey R Stain H Morgan J Malinovskiy D | 2004 | Geostandard and Geoanalytical Research2004，28，1： | 1 |
| 20 | A deficiency of CD4+CD25+T cells permits the development of spontaneous lupus-like disease in mice,and can be reversed by induction of mucosal tolerance to histone peptide autoantigen显示文摘 | Wu H Y Staines N A | | 0，，03： | 1 |
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