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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Critical analysis of the phase behavior of poly ( ε-caprolactone ) ( PCL )/polycarbonate ( PC ) blends 显示文摘 | Cheung Y W Stain R S | 1994 | Macromolecules1994，27，9： | 1 |
| 3 | Molecular studies of identification of genes for osteoporosis: the 2002 update显示文摘 | Stains JP Civitelli R | 2003 | J Endocrinol2003，177，2： | 1 |
| 4 | Lipoprotein (a) in patients with spontaneous venous thromboembolism显示文摘 | Vormittag R Vukovich T Stain M | 2007 | Thromb Res2007，120，： | 1 |
| 5 | Calculation of AC loss in an HTS wind turbine generator显示文摘 | FEE M STAINES M P BUCKLEY R G | 2003 | IEEE Trans on Applied Superconductivity2003，13，2： | 1 |
| 6 | Cell-to-cell interactions in bone 显示文摘 | Stains J P Civitelli R | 2005 | Bioehem Biophys Res Commun2005，328，： | 1 |
| 7 | Transmitters contained in the efferents of the habenula显示文摘 | VINCENT S R STAINES W A MCGEER E G | 1980 | Brain Research1980，195，2： | 1 |
| 8 | Gap junctions in skeletal development and function显示文摘 | Stains JP Civitelli R | 2005 | Biochim Biophys Acta2005，1719，12： | 1 |
| 9 | Analysis and compensation of inverter nonlinearity effect on a sensorless PMSM drive at very Low and zero speed operation显示文摘 | Raute R Caruana C Staines C S | 2010 | IEEE Transactions on Industrial Electronics2010，57，40： | 1 |
| 10 | Analysis and com- pensation of inverter nonlinearity effect on a sensorless PMSM drive at very low and zero speed operation显示文摘 | Raute R Caruana C Staines C S | 2010 | IEEE Transactions on Industrial Electronics''2010，57，12： | 1 |
| 11 | Cell-to-cell interactions in bone显示文摘 | Stains JP Civitelli R | 2005 | Biochem BiophysRes Commun2005，328，： | 1 |
| 12 | Preparation and certification of Re-Os dating reference materials:Molybdenite HIP and JDC显示文摘 | Du A Wu S Sun D Wang S Qu W Markey R Stain H Morgan J Malinovskiy D | 2004 | Geostandard and Geoanalytical Research2004，28，1： | 1 |
| 13 | Gap junction in skeletal development and function显示文摘 | Stains JP Civitelli R | 2005 | Biochim Biophys Acta2005，1719，： | 1 |
| 14 | Management of duodenal perforation after endoscopic retrograde cholangiopancreatography and sphincterotomy 显示文摘 | Stapler M Selby R Stain SC | 2000 | Ann Surg2000，232，2： | 1 |
| 15 | Fabrica- tion of fiber optic long period gratings operating at the phase matching turning point using an ultraviolet laser 显示文摘 | Wong R Y N Chehura E Staines S E | 2014 | Applied Optics2014，53，21： | 1 |
| 16 | Management of duodenal perforation after endoscopic retrograde cholangiopancreatography and sphincterotomy显示文摘 | STAPFER M SELBY R R STAIN S C | 2000 | Ann Surg2000，232，： | 1 |
| 17 | Preparation and certification of Re-Os dating reference materials:Molybdenite HLP and JDC显示文摘 | Du A Wu S Sun D Wang S Qu W Markey R Stain H Morgan J Malinovskiy D | 2004 | Geostandard and Geoanalytical Research2004，28，1： | 1 |
| 18 | Heat shock proteins and regulatory T cells 显示文摘 | BRENU E W STAINES D R TAJOURI L | 2013 | Autoimmune Dis2013，，81： | 1 |
| 19 | Risk mitiga- tion in the development of a Roebel cable based 1 MVA HTS transformer显示文摘 | GLASSON N STAINES M BADCOCK R | 2012 | Physics Procedia2012，36，： | 1 |
| 20 | Preparation and certification of Re-Os dating reference materials:Molybdenite HLP and JDC显示文摘 | Du A D Wu S Q Sun D Z Wang S X Qu W J Markey R Stain H Morgan J Malinovskiy D | 2004 | Geostandard and Geoanalytical Research2004，28，1： | 1 |
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