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| 1 | Reversed-phase fused-core HPLC modeling of peptides显示文摘Different fused-core stationary phase chemistries(C18,Amide,Phenyl-hexyl and Peptide ES-C18) were used for the analysis of 21 structurally representative model peptides.In addition,the effects of the mobile phase composition(ACN or MeOH as organic modifier;formic acid or acetic acid,as acidifying component) on the column selectivity,peak shape and overall chromatographic performance were evaluated.The RP-amide column,combined with a formic acid-acetonitrile based gradient system,performed as best.A peptide reversed-phase retention model is proposed,consisting of 5 variables:log SumAA,log Sv,clog P,log nHDon and log nHAcc.Quantitative structure-retention relationship(QSRR) models were constructed for 16 different chromatographic systems.The accuracy of this peptide retention model was demonstrated by the comparison between predicted and experimentally obtained retention times,explaining on average 86% of the variability.Moreover,using an external set of 5 validation peptides,the predictive power of the model was also demonstrated.This peptide retention model includes the novel in-silico calculated amino acid descriptor,AA,which was calculated from log P,3D-MoRSE,RDF and WHIM descriptors. | Matthias D'Hondt Bert Gevaert Sofie Stalmans Sylvia Van Dorpe Evelien Wynendaele Kathelijne Peremans Christian Burvenich Bart De Spiegeleer | 2013 | Journal of Pharmaceutical Analysis2013，3，2： | 3 |
| 2 | 不同相状态下CuAlNi形状记忆单晶体的超弹性行为显示文摘采用沿CuAlNi单晶 β相 <0 0 1>方向施加拉应力的方法研究了各特征温度范围的超弹行为 .研究表明 :由Af以上在较高应力下冷却至Mf以下卸载时有很高的弹性回复 ;在Mf以下施加较大载荷并卸载后有超弹应变 ;Af以上加载贯穿整个降温升温循环过程产生大于 8%的应力双程形状记忆效应 ;Af以上等温负载导致应力诱发马氏体的稳定化 ,稳定化后的材料可通过热循环或Af~Md 间的加载 -立即卸载循环实现“反稳定化” ;等温处理还会造成应力诱发马氏体的“再稳定化” . | 陈庆福 赵连城 R Stalmans J Van Humbeeck | 2000 | 哈尔滨工业大学学报2000，32，5： | 3 |
| 3 | Specific features of glycogen metabolism in the liver显示文摘 | BOLLEN M KEPPENS S STALMANS W | 1998 | Biochem J1998，336，1： | 1 |
| 4 | Comparison of ICare,dynamic contour tonometer,and ocular response analyzer with Goldmann applanation tonometer in patients with glaucoma显示文摘 | Vandewalle E Vandenbroeck S Stalmans I | 2009 | Eur J Ophthalmol2009，19，5： | 1 |
| 5 | Correlation between ocular pulse amplitude measured by dynamic contour tonometer and visual field defects显示文摘 | Vulsteke C Stalmans I Fieuws S | 2008 | Graefes Arch Clin Exp Ophthalmol2008，246，4： | 1 |
| 6 | Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms 显示文摘 | I Stalmans YS Ng R Rohan | 2002 | J Clin Invest2002，109，： | 1 |
| 7 | Microplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy:the MIVI Ⅰ trial显示文摘 | de Smet MD Gandorfer A Stalmans P | | 0，，07： | 1 |
| 8 | Comparison of postoperative comfort in20 gauge versus 23 gauge pars plana vitrectomy显示文摘 | Mentens R Stalmans P | 2009 | Bull Soc Belge Ophtalmol2009，311，： | 1 |
| 9 | Intravitreal injection of microplasmin for treatment of vitreomacular adhesion:results of a prospective,randomized,sham-controlled phase Ⅱ trial(the MIⅥ-ⅡT trial)显示文摘 | Stalmans P Delaey C de Smet MD | | 0，，07： | 1 |
| 10 | Intravitreal injection of microplasmin for treatment of vitreomacular adhesion: results of a prospective,randomized,sham-controlled phase II trial ( the MIVI- II T trial) 显示文摘 | Stalmans P Delaey C de Smet MD | 2010 | Retina2010，30，： | 1 |
| 11 | The inhibition of the insulin receptor by the membrane protein PC-1 is not specific and results from hydrolysis of ATP 显示文摘 | Stefan C Wera S Stalmans W | 1996 | Diabetes1996，45，： | 1 |
| 12 | Trypan blue staining of epiretinal membranes in proliferative vitreoretinopathy显示文摘 | Feron EJ Veckcneer M Parys-Van Ginderdeuren R Van Lommei A Melles GR Stalmans P | 2002 | Arch Optholmol2002，120，2： | 1 |
| 13 | Outcomes of different management options for malignantglaucoma: a retrospective study 显示文摘 | Debrouwere V Stalmans P Van Calster J | 2012 | Graefes Arch Clin Exp Ophthal- mol2012，250，1： | 1 |
| 14 | Enzymatic vitreolysis with ocfiplasmin for vitreomacular traction and macular holes显示文摘 | Stalmans P Benz MS Gandorfer A | 2012 | N Engl J Med2012，，7： | 1 |
| 15 | Irritable bowel syndrome in primary care:the patients' and doctors' views on symptoms,etiology and management显示文摘 | Bijkerk CJ de Wit NJ Stalman WA | 2003 | Can J Gastroenterol2003，17，6： | 1 |
| 16 | Comparison of postoperative comfort in20gauge versus 23 gauge pars plana vitrectomy显示文摘 | Mentens R Stalmans P | 2009 | Bull SocBeige Ophthalmol2009，，311： | 1 |
| 17 | The safety and efficacy of glaucoma medication in the pediatric population显示文摘 | Coppens G Stalmans I Zeyen T | 2009 | J Pediatr Oph- thalmol Strabismus2009，46，1： | 1 |
| 18 | Toxic effect of indocyanine green on retinal pigment epithelium related to osmotic effects of the solvent显示文摘 | Stalmans P Van Aken E H Veckeneer M | 2002 | Am J Oph- thalmol2002，134，： | 1 |
| 19 | Enzy-matic vitreolysis with ocriplasmin for vitreomacular traction and macular holes显示文摘 | STALMANS P BENZ M S GANDORFER A | 2012 | N Engl J Med2012，367，7： | 1 |
| 20 | Intravitreal injection of microplasmin for treatment of vitreomacular adhesion:results of a prospective,randomized,sham-controlled phase II trial(the MIVI-IIT trial)显示文摘 | STALMANS P DELAEY C SMET M D | 2010 | Retina2010，30，7： | 1 |
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