|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 2 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 3 | Overfeeding macronutrients to critically ill adults:Metabolic complications显示文摘 | KLEIN C J STANEK G S WILES C E | 1998 | J Am Diet Assoc1998，98，： | 1 |
| 4 | Lack of synergy of erythromycin combined with penicillin or cefotaxime against Sreeptococcus pneumonia in vitro显示文摘 | Lin E Stanek RJ Mufson MA | 2003 | Antimicrob Agents Chem2003，47，3： | 1 |
| 5 | Below background levels of blood lead impact cytokine levels in male and female mice 显示文摘 | IAVICOLI G CARELLI E J STANEK | 2006 | Toxicol Appl Pharmacol2006，210，12： | 1 |
| 6 | Amlodipine overdose显示文摘 | Stanek E J Nelson CE DeNofrio D | 1997 | Ann Pharma- co - therapy1997，31，78： | 1 |
| 7 | Statin use in asthmatics on inhaled corticosteroids is associated with decreased risk of emergency department visits显示文摘 | Tse SM Charland SL Stanek E | 2014 | Curr Med Res Opin2014，30，4： | 1 |
| 8 | Soil ingestion: a concern for acute toxicity in children显示文摘 | Calabrese EJ Stanek E J James RC | 1999 | J Environ Health1999，61，： | 1 |
| 9 | Hormesis and stage specific toxicity induced by cadmium in an insect model,the queen blowfly, Phormia regina Meig显示文摘 | NASCARELLA M A STOFFOLANO J G Jr STANEK E J 3rd | 2003 | Environ Pollut2003，124，： | 1 |
| 10 | Facial pattern differences in long -face children and adults 显示文摘 | Fields HW Prottit WB Nixon WL Phillips C Stanek E | 1984 | Am J Orthod1984，85，： | 1 |
| 11 | Seasonal varia tion in serum cholesterol levels= treatment implications and possible meehanisms显示文摘 | Ockene I S Chiriboga D E Stanek E J | 2004 | Arch Intern Med 1642004，8，： | 1 |
| 12 | The ARBITER 6-HALTS Trial (Arterial biology for the treatment effects of reducing cholesterol 6-HDL and LDL treatment strategies in atheroclerosis):final results and the impact of medication adherence,dose,and treatment duration显示文摘 | VILLINES T C STANEK E J DEVINE P J | 2010 | J Am Coll Cardiol2010，55，： | 1 |
| 13 | On the calculation of breakdown voltages for uniform electric fields in compressed air and SF6 显示文摘 | Abdel-Salam M Stanek E K | 1988 | IEEETrans on Industry Applications1988，24，6： | 1 |
| 14 | Mathematical-physicalmodel of corona from surges on high-voltage lines 显示文摘 | Abdel-Salam M Stanek E K | 1987 | IEEE Transactions on Industry Applications1987，23，48： | 1 |
| 15 | Prolactin-induced mitogenesis of lymphocytes from ovariectomized rats显示文摘 | VISELLI S M STANEK E M MUKHERJEE P | 1991 | Endocrinology1991，129，： | 1 |
| 16 | Evaluation of efficacy of Neoseiulus cucumeris for control of western flower thrips in spring bedding crops显示文摘 | Van Driesche R G Lyon S Stanek E J | 2006 | Biological Control2006，36，： | 1 |
| 17 | Lack of synergy of erythro-mycin combined with penicillin or cefotaxime against Strepto-coccus pneumoniae in vitro 显示文摘 | Lin E Stanek R J Mufson MA | 2003 | Antimicrob Agents Chemoth-er2003，47，3： | 1 |
| 18 | Evaluation of efficacy of Neoseiulus cucumeris for control of western flower thrips in spring bedding crops显示文摘 | van Driesche R G Lyon S Stanek III E J Xu B Nunn C | 2006 | Biological Control2006，36，： | 1 |
| 19 | Risk of breast cancer recurrence in women initiating tamoxifen with CYP2D6 inhibitors 显示文摘 | Aubert RE Stanek E J Yao J | 2009 | J Clin Oncol2009，28，： | 1 |
| 20 | Association between dietary fiber and serum C-reactive protein 显示文摘 | Ma Y Griffith J A Chasan-Taber L Olendzki B C Jackson E Stanek Ⅲ E J Li W Pagoto S L Hafner A R Ockene I S | 2006 | The American Journal of Clinical Nutrition2006，83，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员