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| 1 | Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy显示文摘AIM: To investigate plasma ghrelin, gastrin and growth hormone secretagogue receptor (GHS-R) expression in advanced gastric cancer (GC) before and after resection. METHODS: Seventy subjects in whom endoscopy of the upper gastrointestinal tract was performed in the Department of General Surgery at Cracow University during the past decade: (1) 25 patients with GC associated with Helicobacter pylori (H. pylori) infection; (2) 10 patients with GC 4-5 years after (total or subtotal) gastrectomy; (3) 25 healthy H. pylori-negative controls, matched by age and BMI to the above two groups; and (4) 10 GC patients 4-5 years after total gastrectomy. Ghrelin and gastrin plasma concentrations were measured by specific radioimmunoassay under fasting conditions and postprandially at 60 and 90 min after ingestion of a mixed meal. GHS-R expression was examined in biopsy samples from intact healthy mucosa and GC tissue using semi-quantitative reverse transcription-polymerase chain reaction. RESULTS: In healthy controls, fasting plasma ghrelin levels were significantly elevated and declined markedly at 60 and 90 min after a mixed meal. The concomitant enhanced ghrelin, GHS-R and gastrin expression in GC tissue over that recorded in intact mucosa, and the marked rise in plasma gastrin in these subjects under fasting conditions indicate the role of these hormonal factors in GC formation. Fasting plasma levels and postprandial response of ghrelin and gastrin appear to be inversely correlated in healthy subjects. Feeding in the controls resulted in a significant fall in plasma ghrelin with a subsequent rise in plasma gastrin, but in H. pylori-positive GC patients submitted to total or distal gastrectomy, feeding failed to affect significantly the fall in plasma ghrelin that was recorded in these patients before surgery. Fasting ghrelin concentrations were significantly lower in patients 4-5 years after total gastrectomy compared to those in healthy controls and to these in GC patients before surgery. CONCLUSION: Elevated plasma gastrin and suppression of fasting ghrelin in patients with GC suggest the existence of a close relationship between these two hormones in gastric carcinogenesis. | Anna Zub-Pokrowiecka Kazimierz Rembiasz Peter C Konturek Andrzej Budzyński Stanisaw J Konturek Marek Winiarski Wadysaw Bielański | 2011 | World Journal of Gastroenterology2011，17，4： | 7 |
| 2 | The use of acellular dermal graft for vulvovaginal reconstruction in a patient with lichen planus显示文摘 | STANY M P WINTER W E ELKAS J C | 2005 | Obstet Gynecol2005，105，52： | 1 |
| 3 | Polymorphism within the bovine prolactin receptor gene (PRLR)显示文摘 | PaweBrym Stanis aw Kamiński Elbieta Wójcik | 2005 | Animal Science Papers and Reports2005，23，1： | 1 |
| 4 | Leisure Time Physical Activity of Park Visitors: Retesting Constraint Models in Adoption and Maintenance Stages 显示文摘 | Sonja A Stanis W | 2009 | Leisure Sciences2009，31，2： | 1 |
| 5 | Detection of Specific Helicobacter pylori DNA and Antigens in Stool Samples in Dyspeptic Patients and Healthy Subjects显示文摘 | Monika Wi?niewska Hans Olof Nilsson Leokadia B?lk‐Romaniszyn Tomasz Rechciński W?adys?aw Bielański Izabela P?aneta‐Ma?ecka Ma?gorzata P?onka Stanis?aw Konturek Torkel Wadstr?m Wies?awa Rudnicka Magdalena Chmiela | 2002 | Microbiology and Immunology2002，，10： | 1 |
| 6 | Exploring the distribution of park availability, features, and quality across Kansas City, Missouri by income and race/ethnicity: an environmental justice investigation显示文摘 | Vaughan K B Kaczynski A T Stanis S A W | 2013 | Annals n f Beha vioral Medicine2013，45，1： | 1 |
| 7 | 3D printing of bio-instructive materials:Toward directing the cell显示文摘Fabrication of functional scaffolds for tissue engineering and regenerative medicine applications requires material systems with precise control over cellular performance.3D printing is a powerful technique to create highly complex and multicomponent structures with well-defined architecture and composition.In this review paper,we explore extrusion-based 3D printing methods(EBP,i.e.,Near Field Electrospinning(NFES),Melt Electrowriting(MEW),Fused Deposition Modeling(FDM),and extrusion bioprinting)in terms of their ability to produce scaffolds with bio-instructive properties.These material systems provide spatio-temporal guidance for cells,allowing controlled tissue regeneration and maturation.Multiple physical and biochemical cues introduced to the EBP scaffolds are evaluated in their ability to direct cell alignment,proliferation,differentiation,specific ECM production,and tissue maturation.We indicate that the cues have different impacts depending on the material system,cell type used,or coexistence of multiple cues.Therefore,they must be carefully chosen based on the targeted application.We propose future directions in bio-instructive materials development,including such concepts as metamaterials,hybrid living materials,and 4D printing.The review gathers the knowledge essential for designing new materials with a controlled cellular response,fabrication of advanced engineered tissue,and developing a better understanding of cell biology,especially in response to the biomaterial. | Piotr Stanisław Zielinski Pavan Kumar Reddy Gudeti Timo Rikmanspoel Małgorzata Katarzyna Włodarczyk-Biegun | 2023 | Bioactive Materials2023，，1： | 1 |
| 8 | Leisure time physical activity of park visitors: Retesting constraint models in a-doption and maintenance stages 显示文摘 | Stanis S A W Schneider I E Russell K C | 2009 | Leisure Sciences2009，31，3： | 1 |
| 9 | State park visitors' leisure time physical activity, constraints, and negotiation strategies 显示文摘 | STANIS S A W SCHNEIDER I E ANDERSON D H | 2009 | Journal of Park and Recreation Administration2009，3，27： | 1 |
| 10 | Extracranial internal ca- rotid artery dissection treated with self - expandable stents: a single - centre experience显示文摘 | Juszkat R Liebert W Stanis~awska K | 2015 | Cardiovasc Intervent Radiol2015，38，6： | 1 |
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