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| 1 | A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein显示文摘最新新兴的中东呼吸症候群 coronavirus (MERS-CoV ) 能在人引起严重、致命的急性呼吸疾病。尽管有全球努力,潜力为一联系在未来流行不能被排除。有效相对的措施的发展是迫切的。MERS-CoV-specific 抗病毒的药或疫苗是还没可得到的。使用 MERS-CoV (MERS-RBD ) 的尖铁受体绑定领域使老鼠免疫,我们识别了二抵销 monoclonal 抗体(mAbs ) 4C2 和 2E6。两 mAbs potently 与高功效在 vitro 绑在 MERS-RBD 和块病毒入口。我们进一步由使在 Fab 碎片和 RBD 之间的建筑群结晶调查了他们中立化的机制,并且解决了 4C2 Fab/MERS-RBD 建筑群的结构。结构证明 4C2 认出部分重叠的 epitope 在 MERS-RBD 的受体绑定脚印,从而由位的阻碍者和接口残余竞争防碍病毒 / 受体相互作用。2E6 也堵住受体绑定,并且为绑定与 4C2 竞争到 MERS-RBD。基于结构,我们进一步由保存仅仅 paratope 残余并且从人的免疫球蛋白与对应物代替留下的氨基酸使 4C2 人性化。人性化的 4C2 (4C2h ) 抗体支撑了类似的抵销的活动和生物化学的特征到父母老鼠抗体。最后,我们证明 4C2h 能显著地在感染 MERS-CoV 的 Ad5-hCD26-transduced 鼠标的肺消除病毒 titers,因此在临床的设置为预防和治疗代表一个有希望的代理人。 | Yan Li YuhuaWan Peipei Liu Jincun Zhao Guangwen Lu Jianxun Qi Qihui Wang Xuancheng LU Ying Wu Weniun Liu Buchang Zhang Kwok-Yung Yuen Stanley Perlman George F Gao Jinghua Yan | 2015 | Cell Research2015，25，11： | 14 |
| 2 | Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus显示文摘 | Naru Zhang Rudragouda Channappanavar Cuiqing Ma Lili Wang Jian Tang Tania Garron Xinrong Tao Sumaiya Tasneem Lu Lu Chien-Te K Tseng Yusen Zhou Stanley Perlman Shibo Jiang Lanying Du | 2016 | Cellular & Molecular Immunology2016，13，2： | 12 |
| 3 | Subclinical atherosclerosis in northern and southern China: the Chinese paradox显示文摘背景冠的心疾病(CHD ) 的发生是更高的在北比在南部的中国,然而,在传统的 CHD 的差别冒险的,解释这。没有学习在可以帮助在发生解释差别的无临床症状的动脉粥样硬化检验了差别。这研究为在北、南部的中国之间的石灰化用冠的计算断层摄影术(CT ) 在无临床症状的动脉粥样硬化检验了这些差别。我们在一个大多中心选择了参加者的一件随机的样品的方法为冠的钙在一个北城市(诺思) 里扫描的进行中的流行病的学习(北京, n = 49 ) 并且在二个南部的城市(南方) 里(上海, n = 50,并且广州, n = 50 ) 。从三个领域中心的参加者(意味着年龄 67 年) 经历了用动脉粥样硬化扫描的多种族的学习为冠的钙测量扫描的冠的风险因素评估和心脏的 CT 协议。结果调整了在诺思中国(北京) 的转变木头的冠的动脉钙 20 是 3.1 +/-0.4 并且在华南(上海和广州) 是 2.2 +/- 0.3 (P = 0.04 ) 。为北京的北城市的吝啬的钙分数比广州的南部的城市的高三倍(P = 0.01 ) 并且比为上海的南部的城市高 2.5 倍(P = 0.03 ) 。结论无临床症状的动脉粥样硬化的程度在广州和上海的二个南部的城市里比那在北京的北城市里是显著地更高的,甚至在为标准心脏的风险因素调整以后。这发现建议标准风险因素充分不在临床的 CHD 发生解释北方南方差别。 | Jie Huang Yang-Feng Wu Xiao-Qing Liu Ding Ding Lian-Cheng Zhao Bin Lu Xian Li Nathan D Wong Laurie D Dustin Stanley P Azen Robert C Detrano | 2011 | Journal of Geriatric Cardiology2011，8，2： | 7 |
| 4 | History-dependent percolation on multiplex networks显示文摘The structure of interconnected systems and its impact on the system dynamics is a much-studied cross-disciplinary topic.Although various critical phenomena have been found in different models;study of the connections between different percolation transitions is still lacking.Here we propose a unified framework to study the origins of the discontinuous transitions of the percolation process on interacting networks.The model evolves in generations with the result of the present percolation depending on the previous state,and thus is history-dependent.Both theoretical analysis and Monte Carlo simulations reveal that the nature of the transition remains the same at firdte generations but exhibits an abrupt change for the infinite generation.We use brain functional correlation and morphological similarity data to show that our model also provides a general method to explore the network structure and can contribute to many practical applications,such as detecting the abnormal structures of human brain networks. | Ming Li Linyuan Lu Youjin Deng Mao-Bin Hu Hao Wang Matus Medo H.Eugene Stanley | 2020 | National Science Review2020，7，8： | 3 |
| 5 | Peritumoral Diffusion Tensor Imaging of High Grade Gliomas and Metastatic Brain Tumors显示文摘 | Stanley Lu Daniel Ahn Glyn Johnson | 2003 | AJNR Am J Neuroradiol2003，24，5： | 1 |
| 6 | Identification of residues in ornithine decarboxylase essential for enzymic activity and for rapid protein turnover显示文摘 | Lu L Stanley BA Pegg AE | 1991 | Biochem J1991，277，： | 1 |
| 7 | Design,simulation,fabrication and measurement of a 25nm,50% slider显示文摘 | S Lu H M Stanley D B Bogy | 1995 | IEEE Trans Magn1995，31，6： | 1 |
| 8 | Pcritumoral Diffusion Tensor hnaging of High Grade Gliomas and Mela static Brain Tumors显示文摘 | Stanley Lu Daniel Ahn Glyn Johnson | 2003 | AJNR An: J Neuroradiol2003，24，5： | 1 |
| 9 | Peritumoral Diffusion Tensor Imaging of High Grade Gliomas and Metastatic Brain Tumors显示文摘 | Stanley Lu Daniel Ahn Glyn Johnson | 2003 | AJNR2003，24，5： | 1 |
| 10 | Roles of O-fucose glycans in notch signaling revealed by mutant mice显示文摘 | Lu L Stanley P | 2006 | Methods Enzymol2006，417，： | 1 |
| 11 | Fast Global Minimization of the Active Contour/Snake Model显示文摘 | Xavier Bresson Selim Esedog?lu Pierre Vandergheynst Jean-Philippe Thiran Stanley Osher | 2007 | Journal of Mathematical Imaging and Vision2007，，2： | 1 |
| 12 | Design, simulation, fabrication and measurement of a 25 nm, 50% slider显示文摘 | LU S STANLEY H M BOGY D B | 1995 | IEEE Transactions on Magnetics1995，31，6： | 1 |
| 13 | Identification of residues in ornithine decarboxylase essential for enzymic activity and for rapid protein turnover显示文摘 | Lu L Stanley BA Pegg AE | 1991 | Biochem J1991，277，： | 1 |
| 14 | Diffusion- Tensor MR Imaging of Intracranial Neoplasia and Associated Peritumoral Edema: Introduction of the Tumor Infiltration Index显示文摘 | Stanley Lu Daniel Ahn 61yn Johnson | 2004 | Radiology2004，232，： | 1 |
| 15 | Design, simulation, fabrication and measurement of a 25 nm, 50% slider 显示文摘 | Lu S Stanley H M Bogy D B | 1995 | IEEE Transactions on Magnetics1995，3，6： | 1 |
| 16 | Diffusion-Weighted MRI in Acute Subcortical Infarction显示文摘 | Michael B. Singer June Chong Dongfeng Lu Wouter J. Schonewille Stanley Tuhrim Scott W. Atlas | 1998 | Stroke A Journal of Cerebral Circulation1998，，1： | 1 |
| 17 | Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients显示文摘 | James M. O’Brien Bo Lu Naeem A. Ali Greg S. Martin Scott K. Aberegg Clay B. Marsh Stanley Lemeshow Ivor S. Douglas | 2007 | Critical Care Medicine2007，，2： | 1 |
| 18 | Peritumoral diffusion tensor imaging of highgrade gliomas and metastatic brain tumors显示文摘 | Stanley Lu Daniel Ahn Glyn Johnson | 2003 | AJNR2003，24，8： | 1 |
| 19 | 深圳能源大厦显示文摘深圳能源公司办公楼项目总建筑面积为96000m^2,旨在让人在深圳的文化、政治和商业中心感到亲切的同时,在城市主轴线上建造一座可持续的新公共地标。本项目的体量和高度由中心区城市总体规划决定。主体建筑由两座塔楼组成,北楼高220m,南楼高120m,两座塔楼与邻近建筑的塔楼一起在深圳的中心形成一个连续的弧形天际线。 | Bjarke Ingels Andreas Klok Pedersen Martin Voelkle He Song Andre Schmidt Alessio Zenaro Alina Tamosiunaite Alysen Hiller Ana Merino Andreas Geisler Johansen Annette Jensen Armor Rivas Balaj IIulian Brian Yang Baptiste Blot Buster Christiansen Cecilia Ho Christian Alvarez Christin Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Dave Brown Dennis Rasmussen Doug Stechschulte Eskild Nordbud Felicia Guldberg Fred Zhou Gaetan Brunet Gül Ertekin Henrik Kania Iris Van der Heide James Schrader Jan Magasanik Jan Borgstr?m Jeppe Ecklon Jelena Vucic Jo?o Albuquerque Jonas M?nster Karsten Hansen Malte Kloe Mikkel Marcker Stubgaard Michael Andersen Michal Kristof Min Ter Lim Oana Simionescu Nicklas A. Rasch Philip Sima Rasmus Pedersen Rune Hansen Rui Huang Sofia Gaspar Stanley Lung Sun Ming Lee Takuya Hosokai Todd Bennett Xi Chen Xing Xiong Xiao Lu Xu Li Yijie Dan Zoltan Kalaszi | 2019 | 建筑实践2019，2，6： | 0 |
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