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| 1 | Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro显示文摘Sertoli 房间紧密的连接(TJ ) 是血睾丸障碍的关键部件,在它扣押开发在生精的小管以内经历精子发生的细菌房间的地方。神经质地调整的 claudin-11 是在不孕涉及障碍功能和它的鼠科的猛烈结果的批评 transmembrane 蛋白质。我们试图估计份量上到 TJ 功能的 claudin-11 的贡献的意义在 vitro,使用调停 siRNA 的基因 silencing。我们也进行了 occludin 的贡献的分析, TJ 的另一内在的 transmembrane 蛋白质。claudin-11 或 occludin 的 Silencing 在一个不成熟的老鼠 Sertoli 房间文化模型用 siRNA 被进行。Transepithelial 电的抵抗被用来在整个文化估计份量上 TJ 功能。在 siRNA 处理以后的二天,房间为对 mRNA 的 RT-PCR 评价为连接蛋白质或 lyzed 的 immunocytochemical 本地化被修理表示。claudin-11, occludin,或两个的 Silencing 在 55% 的 TJ 功能导致了重要减少(P <0.01 ) , 51%(P <0.01 ) ,并且 62%(P <0.01 ) 分别地。数据在到 Sertoli 房间 TJ 的指向的蛋白质的本地化是有在 mRNA 表示和显著减小的重要减少的伴随物。我们提供 claudin-11 显著地贡献的量的证据(P <0.01 ) 到 Sertoli 房间 TJ 在 vitro 工作。有趣地, occludin,神经质地在不孕被调整然而并非含有直到迟了的成人生活,也是一重要(P <0.01 ) 贡献者到障碍功能。我们的数据与一致在清楚地为这些表明一个角色的 vivo 研究,在维持正常 TJ 障碍的蛋白质组织并且工作。 | Mark J McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G Stanton | 2016 | Asian Journal of Andrology2016，18，4： | 7 |
| 2 | A hybrid reinforced preeast frame for seismic regions 显示文摘 | Stanton J F Stone W Cheok G | 1997 | PCI Journal1997，42，2： | 1 |
| 3 | The standardization of terminology of lower u-rinary tract function recommended by the international continence society显示文摘 | Abrams P Blaivas J G Stanton S L | 1990 | Int Urogy-necol1990，1，： | 1 |
| 4 | Self-concept:Validation of construct interpretations显示文摘 | HUBNER J J STANTON G C | 1976 | Reviewof Educational Research1976，，46： | 1 |
| 5 | Determination of seasonality in southern hairy-nosed wombats(Lasiorhinus latifrons)by analysis of fecal androgens 显示文摘 | Hamihon R A Stanton P G Donnell L | 2000 | Biology of Repro-duction2000，63，： | 1 |
| 6 | Self-concept: Validation of construct interpretations显示文摘 | Shavclson R J Hubner J J and Stanton G C | 1976 | Review of Educational Research1976，46，3： | 1 |
| 7 | Genomic diversity within the genus pediococcus as revealed by randomly amplified polymorphic DNA PCR and pulsed-field gel electrophoresis显示文摘 | Simpson P J Stanton C Fitzgerald G F | | 0，，： | 1 |
| 8 | Perceptions of Shigella and of Shigella vaccine among rural Chinese:compatibility with Western models of behavioral change显示文摘 | YOULONG G STANTON BF VON SEIDLEN L | 2004 | Southeast Asian J Trop Med Public Health2004，35，： | 1 |
| 9 | CD36 is a receptor for oxidized low density lipoprotein显示文摘 | Endemann G Stanton LW Madden KS | 1993 | Journal of Biological Chemistry1993，268，11： | 1 |
| 10 | Self-concept:Validation of construct interpretation显示文摘 | Hubner J J & STANTON G C | 1976 | Review of Educational Research1976，46，： | 1 |
| 11 | Studies on isoproterenol-induced cardiomegaly in rats显示文摘 | Stanton HC Brenner G Mayfield ED Jr | 1969 | Am Heart J1969，77，1： | 1 |
| 12 | Mechanisms for pro-matrix metalloproteinase activation显示文摘 | Murphy G Stanton H Cowell S | 1999 | APMIS1999，107，1： | 1 |
| 13 | Anhydrobiotics : The challenges of drying probiotic cultures 显示文摘 | Meng X C Stanton C Fitzgerald G F | 2008 | Food Chemistry2008，106，： | 1 |
| 14 | Phase Ⅱ trial of thalidomide and daily oral dexamethasone for treatment of hormone refractory prostate cancer progressing after chemotherapy显示文摘 | Romero S Stanton G DeFellce J | 2007 | Urol Oncol2007，25，4： | 1 |
| 15 | Fermented functional foods based on probiotics and their biogenic metabolites显示文摘 | STANTON C ROSS R P FITZGERALD G F | 2005 | Current Opinion in Biotechnology2005，16，2： | 1 |
| 16 | Resonance enhanced dynamic Rayleigh scattering 显示文摘 | Stanton S G | 1981 | J Chem Phys1981，75，12： | 1 |
| 17 | Performance of Hybrid Moment-Resisting Precast Beam-Column Concrete Connections Subjected to Cyclic Loading显示文摘 | Stone W C Cheok G S Stanton J F | 1995 | ACI Structural Journal1995，，2： | 1 |
| 18 | Self-concept: Validation of construct interpretations显示文摘 | Shavelson R J Hubner JJ Stanton G C | 1976 | Review of Educational Research1976，46，： | 1 |
| 19 | Studies on isoproterenolinduced cardiomegaly in rats显示文摘 | Stanton HC Brenner G Mayfield ED Jr | 1969 | Am Heart J1969，77，1： | 1 |
| 20 | Environmental adaptation of probiotic lactobacilli towards improvement of performance during spray drying 显示文摘 | Desmond C Stanton C Fitzgerald G F | 2001 | International Dairy Journal2001，11，10： | 1 |
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