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| 1 | Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro显示文摘Sertoli 房间紧密的连接(TJ ) 是血睾丸障碍的关键部件,在它扣押开发在生精的小管以内经历精子发生的细菌房间的地方。神经质地调整的 claudin-11 是在不孕涉及障碍功能和它的鼠科的猛烈结果的批评 transmembrane 蛋白质。我们试图估计份量上到 TJ 功能的 claudin-11 的贡献的意义在 vitro,使用调停 siRNA 的基因 silencing。我们也进行了 occludin 的贡献的分析, TJ 的另一内在的 transmembrane 蛋白质。claudin-11 或 occludin 的 Silencing 在一个不成熟的老鼠 Sertoli 房间文化模型用 siRNA 被进行。Transepithelial 电的抵抗被用来在整个文化估计份量上 TJ 功能。在 siRNA 处理以后的二天,房间为对 mRNA 的 RT-PCR 评价为连接蛋白质或 lyzed 的 immunocytochemical 本地化被修理表示。claudin-11, occludin,或两个的 Silencing 在 55% 的 TJ 功能导致了重要减少(P <0.01 ) , 51%(P <0.01 ) ,并且 62%(P <0.01 ) 分别地。数据在到 Sertoli 房间 TJ 的指向的蛋白质的本地化是有在 mRNA 表示和显著减小的重要减少的伴随物。我们提供 claudin-11 显著地贡献的量的证据(P <0.01 ) 到 Sertoli 房间 TJ 在 vitro 工作。有趣地, occludin,神经质地在不孕被调整然而并非含有直到迟了的成人生活,也是一重要(P <0.01 ) 贡献者到障碍功能。我们的数据与一致在清楚地为这些表明一个角色的 vivo 研究,在维持正常 TJ 障碍的蛋白质组织并且工作。 | Mark J McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G Stanton | 2016 | Asian Journal of Andrology2016，18，4： | 7 |
| 2 | Sentinal node localization in patients with breast cancer显示文摘 | Flett MM Coing J J Stanton PD | 1998 | Br J Surg1998，85，7： | 1 |
| 3 | An overview of the PRESSS five-story precast test building 显示文摘 | Nakaki S D Stanton J F and Sritharan S | 1999 | PCI Journal1999，44，2： | 1 |
| 4 | Emergy evaluation of the performance and sustainability of three agricultural systems with different scales and management显示文摘 | Martin J F Diemont S A W Powell E Stanton M Levy-Tacher S | 2006 | Agriculture Ecosystems&Environment2006，115，14： | 1 |
| 5 | Broadband acoustic baekscatter and high-resolution morphology of fish: Mea- surement and modeling显示文摘 | REEDER D JECH J STANTON T | 2004 | Journal of the Acoustical So- ciety of America2004，116，2： | 1 |
| 6 | Nucleotide polymorphisms and an improved PCR-based mtDNA diagnostic for parthenogenetic root-knot nematodes(Meloidogyne spp)显示文摘 | STANTON J HUGALL A MORITZ C | 1997 | Fundamental and Applied Nematology1997，20，30： | 1 |
| 7 | Effects through 24 months of anHIV/AIDS prevention intervention program based on protectionmotivation theory among preadolescents in the Bahamas显示文摘 | Gong J Stanton B Lunn S | 2009 | Pedi-atrics2009，123，5： | 1 |
| 8 | Negative Affect and Job Search:Further Examination of the Reverse Causation Hypothesis 显示文摘 | CROSSLEY C D STANTON J M | 2005 | Journal of Vocational Behavior2005，66，4： | 1 |
| 9 | Simple phenomenological model for reinforcing steel under arbitrary load 显示文摘 | Hoehler M S Stanton J F | 2006 | Journal of Structural Engineering2006，132，7： | 1 |
| 10 | Analysis of end user securi- ty behaviors显示文摘 | Stanton J Stam K Mastrangelo P | 2005 | Computers & Security2005，24，2： | 1 |
| 11 | Design oI seismic restrainers for in-span hinges 显示文摘 | Trochalakis P EberhardM O Stanton J F | 1997 | Journal of Structural Engineering1997，123，4： | 1 |
| 12 | A hybrid reinforced preeast frame for seismic regions 显示文摘 | Stanton J F Stone W Cheok G | 1997 | PCI Journal1997，42，2： | 1 |
| 13 | A low power low noise amplifier for a 128 channel detector read-out chip 显示文摘 | STANTON J C | 1989 | IEEE Trans Nucl Sci1989，36，1： | 1 |
| 14 | Multifidus size and symmetry among chronic LBP and healthy asymptomatic subjects显示文摘 | Hides J Gilmore C Stanton W | 2008 | Man Ther2008，13，1： | 1 |
| 15 | Neonatal alcohol ex- posure and the hippocampus in developing male rats: effects on be- haviorally induced CA1 c-Fos expression, CA1 pyramidal cell num- ber, and contextual fear conditioning 显示文摘 | Murawski N J Klintsova AY and Stanton ME | 2012 | Neurescience2012，206，： | 1 |
| 16 | Secure spread:an integrated architecture for secure group communication显示文摘 | AMIR Y NITA-ROTARU C STANTON J et a1 | 2005 | IEEE transactions on dependable and secure computing2005，2，3： | 1 |
| 17 | Broadband acoustic baekscatter and high-resolution morphology of fish: measurement and modeling显示文摘 | REEDER D B JECH J M STANTON T K | 2004 | Journal of the Acoustical Society of America2004，116，2： | 1 |
| 18 | Multifidus size and sym- metry among chronic LBP and healthy asymptomatie subjects显示文摘 | Hides J Gilmore C Stanton W | 2008 | Man Ther2008，13，1： | 1 |
| 19 | Frequency Modulation and Wavelength Modulation Spectroscopies显示文摘 | BOMSE S D STANTON C A SILVER A J | 1992 | Applied Optics1992，31，6： | 1 |
| 20 | The standardization of terminology of lower u-rinary tract function recommended by the international continence society显示文摘 | Abrams P Blaivas J G Stanton S L | 1990 | Int Urogy-necol1990，1，： | 1 |
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