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| 1 | Laparoscopic surgery for rectal cancer:The state of the art显示文摘At present time,there is evidence from randomized controlled studies of the success of laparoscopic resection for the treatment of colon cancer with reported smaller incisions,lower morbidity rate and earlier recovery compared to open surgery.Technical limitations and a steep learning curve have limited the wide application of miniinvasive surgery for rectal cancer.The present article discusses the current status of laparoscopic resection for rectal cancer.A review of the more recent retrospective,prospective and randomized controlled trial(RCT) data on laparoscopic resection of rectal cancer including the role of trans-anal endoscopic microsurgery and robotics was performed.A particular emphasis was dedicated to mid and low rectal cancers.Few prospective and RCT trials specif ically addressing laparoscopic rectal cancer resection are currently available in the literature.Improved short-term outcomes in term of lesser intraoperative blood loss,reduced analgesic requirements and a shorter hospital stay have been demonstrated.Concerns have recently been raised in the largest RCT trial of the oncological adequacy of laparoscopy in terms of increased rate of circumferential margin.This data however was not conf irmed by other prospective comparative studies.Moreover,a similar local recurrence rate has been reported in RCT and comparative series.Similar f indings of overall and disease free survival have been reported but the follow-up time period is too short in all these studies and the few RCT trials currently available do not draw any def initive conclusions.On the basis of available data in the literature,the mini-invasive approach to rectal cancer surgery has some short-term advantages and does not seem to confer any disadvantage in term of local recurrence.With respect to longterm survival,a definitive answer cannot be given at present time as the results of RCT trials focused on long-term survival currently ongoing are still to fully clarify this issue. | Carlo Staudacher Andrea Vignali | 2010 | World Journal of Gastrointestinal Surgery2010，2，9： | 16 |
| 2 | Apparent diffusion coefficient by diffusion-weighted magnetic resonance imaging as a sole biomarker for staging and prognosis of gastric cancer显示文摘Objective:To investigate the role of apparent diffusion coefficient(ADC)from diffusion-weighted magnetic resonance imaging(DW-MRI)when applied to the 7th TNM classification in the staging and prognosis of gastric cancer(GC).Methods:Between October 2009 and May 2014,a total of 89 patients with non-metastatic,biopsy proven GC underwent 1.5T DW-MRI,and then treated with radical surgery.Tumor ADC was measured retrospectively and compared with final histology following the 7th TNM staging(local invasion,nodal involvement and according to the different groups—stage I,II and III).Kaplan-Meier curves were also generated.The follow-up period is updated to May 2016.Results:Median follow-up period was 33 months and 45/89(51%)deaths from GC were observed.ADC was significantly different both for local invasion and nodal involvement(P<0.001).Considering final histology as the reference standard,a preoperative ADC cut-off of 1.80×10–3 mm2/s could distinguish between stages I and II and an ADC value of≤1.36×10–3 mm2/s was associated with stage III(P<0.001).Kaplan-Meier curves demonstrated that the survival rates for the three prognostic groups were significantly different according to final histology and ADC cut-offs(P<0.001).Conclusions:ADC is different according to local invasion,nodal involvement and the 7th TNM stage groups for GC,representing a potential,additional prognostic biomarker.The addition of DW-MRI could aid in the staging and risk stratification of GC. | Francesco Giganti Alessandro Ambrosi Damiano Chiari Elena Orsenigo Antonio Esposito Elena Mazza Luca Albarello Carlo Staudacher Alessandro Del Maschio Francesco De Cobelli | 2017 | Chinese Journal of Cancer Research2017，29，2： | 15 |
| 3 | Endoscopic ultrasound and magnetic resonance imaging for re-staging rectal cancer after radiotherapy显示文摘AIM:To compare the sensitivity and specificity of two imaging techniques,endoscopic ultrasound (EUS) and magnetic resonance imaging (MRI),in patients with rectal cancer after neoadjuvant chemoradiation therapy. And we compared EUS and MRI data with histological fi ndings from surgical specimens. METHODS:Thirty-nine consecutive patients (51.3% Male; mean age:68.2 ± 8.9 years) with histologically confirmed distal rectal cancer were examined for staging. All patients underwent EUS and MRI imaging before and after neoadjuvant chemoradiation therapy. RESULTS:After neoadjuvant chemoradiation,EUS and MRI correctly classified 46% (18/39) and 44% (17/39) of patients,respectively,in line with their histological T stage (P > 0.05). These proportions were higher for both techniques when nodal involvement was considered:69% (27/39) and 62% (24/39). When patients were sorted into T and N subgroups,the diagnostic accuracy of EUS was better than MRI for patients withT0-T2 (44% vs 33%,P > 0.05) and N0 disease (87% vs 52%,P = 0.013). However,MRI was more accurate than EUS in T and N staging for patients with more advanced disease after radiotherapy,though these differences did not reach statistical significance. CONCLUSION:EUS and MRI are accurate imaging techniques for staging rectal cancer. However,after neoadjuvant RT-CT,the role of both methods in the assessment of residual rectal tumors remains uncertain. | Gianni Mezzi Paolo Giorgio Arcidiacono Silvia Carrara Francesco Perri Maria Chiara Petrone Francesco De Cobelli Simone Gusmini Carlo Staudacher Alessandro Del Maschio Pier Alberto Testoni | 2009 | World Journal of Gastroenterology2009，15，44： | 9 |
| 4 | Combined laparoscopic spleen-preserving distal pancreatectomy and islet autotransplantation for benign pancreatic neoplasm显示文摘AIM:To evaluate the safety and feasibility of laparoscopic spleen-preserving distal pancreatectomy(LSPDP)with autologous islet transplantation(AIT)for benign tumors of the pancreatic body-neck.METHODS:Three non-diabetic,female patients(age37,44 and 35 years,respectively)were declared candidates for surgery,between May and September 2011,because of pancreatic body/neck cystic lesions.The planned operation was an LSPDP associated with AIT from the normal pancreas distal to the neoplasm.Islets isolation was performed on the residual pancreatic parenchyma after frozen section examination of the margin.Purified autologous islets were infused into the portal vein by a percutaneous transhepatic approach the day after surgery.RESULTS:The procedure was performed successfully in all the three cases,and the spleen was preserved along with its vessels.Mean operation time was 283±52 min and average blood loss was 133±57 mL.Residual pancreas weights were 33,22 and 30 g,and105.200,40.390 and 94.790 islet equivalents were isolated,respectively.Surgical complications occurred in one patient(grade A pancreatic fistula).Postoperative stays were 6,6 and 7 d,respectively.Histopathological evaluation revealed mucinous cystic neoplasm in cases1 and 3,and serous cystic neoplasm in patient 2.No postoperative insulin administration was required.One patient developed a transient partial portal thrombosis2 mo after islet infusion.Patients are insulin independent at a mean follow up of 8±2 mo.CONCLUSION:Combination of LSPDP and AIT is feasible and could be effective to minimize the surgical impact for benign neoplasm of pancreatic body-neck. | Gianpaolo Balzano Michele Carvello Lorenzo Piemonti Rita Nano Riccardo Ariotti Alessia Mercalli Raffaella Melzi Paola Maffi Marco Braga Carlo Staudacher | 2014 | World Journal of Gastroenterology2014，20，14： | 4 |
| 5 | Terrestrial xenology 显示文摘 | Staudacher Th Allegre C J | 1982 | Earth Planet Sci Lett1982，60，： | 2 |
| 6 | Cosmogenic neon and helium at Réunion:measurement of erosion rate 显示文摘 | Sarda Ph Staudacher Th | 1993 | Earth Planet SciLett1993，119，： | 2 |
| 7 | Inflammatorybowel diseases: experiencing illness, therapy and care 显示文摘 | Rettke H Staudacher D Schmid-Bchi S | 2013 | Pflege2013，26，2： | 1 |
| 8 | Rectal Distensibility and Symptoms After Stapled and Milligan–Morgan Operation for Hemorrhoids显示文摘 | Maura Corsetti Paola Nardi Salvatore Pietro Sandro Passaretti Pier Alberto Testoni Carlo Staudacher | 2009 | Journal of Gastrointestinal Surgery2009，，12： | 1 |
| 9 | Modeling and validation of the thermal effects on gas turbine transients显示文摘 | Nielsen A E Moll C W Staudacher S | 2005 | Journal of Engineering for Gas Turbines and Power2005，127，3： | 1 |
| 10 | Laparoscopic vs. Open Colectomies in Octogenarians: A Case-Matched Control Study显示文摘 | Andrea Vignali M.D. Saverio Palo M.D. Andrea Tamburini M.D. Giovanni Radaelli Ph.D. Elena Orsenigo M.D. Carlo Staudacher M.D | 2005 | Diseases of the Colon & Rectum2005，，11： | 1 |
| 11 | Total mesorectal excision (TME) with laparoscopic approach:226 consecutive cases显示文摘 | Staudacher C Di Palo S Tamburini A | 2007 | Surg Oncol2007，16，1： | 1 |
| 12 | Laparoscopic VS open total mesorectal excision in unselected patients with rectalcancer:impact on early outcome显示文摘 | Staudacher C Vignali A Saverio DP | 2007 | Disc Colon Rec2007，50，9： | 1 |
| 13 | Laparoscopic vs. Open Colectomies in Octogenarians: A Case-Matched Control Study显示文摘 | Andrea Vignali Saverio Di Palo Andrea Tamburini Giovanni Radaelli Elena Orsenigo Carlo Staudacher | 2005 | Diseases of the Colon & Rectum2005，，： | 1 |
| 14 | Laparo- seopiev vs open total mcsorectal excision in unselected patients with rectal cancer impact on early outeom 显示文摘 | Staudacher C Vignali A Saverio DP | 2007 | Dis Colon Rectum2007，50，9： | 1 |
| 15 | HERG K+ channel-dependent apoptosis and cell cycle arrest in human glioblastoma cells显示文摘 | Staudacher I Jehle J Staudacher K | 2014 | PLoS One2014，9，88： | 1 |
| 16 | Purification and charac- terization of a beta-xylosidase from potatoes( Solanum tu- berosum) 显示文摘 | Peyer C Bonay P Staudacher E | 2004 | Biochim Biophys Acta2004，1672，： | 1 |
| 17 | Platinum based chem otherapy in metastatic triple negative breast cancer: the Insti- rut Curie experience显示文摘 | Staudacher L Cottu PH Dieras V | 2011 | Ann Oncol2011，22，4： | 1 |
| 18 | Ultrasound diagnostics of the vertebrobasilar system 显示文摘 | von Btidingen HC Staudacher T von Budingen HJ | 2006 | Front Neurol Neurosci2006，21，1： | 1 |
| 19 | Application of Bayesian forecasting to change detection and prognosis of gas turbine performance 显示文摘 | Lipowsky H Staudacher S | 2010 | Journal of Engineering for Gas Turbines and Power2010，132，03： | 1 |
| 20 | Advances in the pathogenesis of atop- ic dermatitis显示文摘 | Hinz T Staudacher A Bieber T | 2006 | Hantarzt2006，57，7： | 1 |
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