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4篇 您的检索式:作者名="Stefan Fu"
    题名 作者 年代 出处 被引量
1Exami- ning student satisfaction with higher education services 显示文摘Thorsten Gruber Stefan Fu Roediger Voss 2010International Journal of Public Sector Management2010,23,2:1
2Correlation between parental transcriptome and field data for the characterization of heterosis in Zea mays L.显示文摘Alexander Thiemann Junjie Fu Tobias A. Schrag Albrecht E. Melchinger Matthias Frisch Stefan Scholten 2010Theoretical and Applied Genetics2010,,2:1
3A visual analytics design for studying rhythm patterns from human daily movement data显示文摘Human’s daily movements exhibit high regularity in a space-time context that typically forms circadian rhythms.Understanding the rhythms for human daily movements is of high interest to a variety of parties from urban planners,transportation analysts,to business strategists.In this paper,we present an interactive visual analytics design for understanding and utilizing data collected from tracking human’s movements.The resulting system identifies and visually presents frequent human movement rhythms to support interactive exploration and analysis of the data over space and time.Case studies using real-world human movement data,including massive urban public transportation data in Singapore and the MIT reality mining dataset,and interviews with transportation researches were conducted to demonstrate the effectiveness and usefulness of our system.Wei Zeng Chi-Wing Fu Stefan Müller Arisona Simon Schubiger Remo Burkhard Kwan-Liu Ma 2017Visual Informatics2017,1,2:0
4TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS显示文摘SARS-CoV-2,the coronavirus that causes the disease COVID-19,has claimed millions of lives over the past 2 years.This demands rapid development of effective therapeutic agents that target various phases of the viral replication cycle.The interaction between host transmembrane serine protease 2(TMPRSS2)and viral SPIKE protein is an important initial step in SARS-CoV-2 infection,offering an opportunity for therapeutic development of viral entry inhibitors.Here,we report the development of a time-resolved fluorescence/Förster resonance energy transfer(TR-FRET)assay for monitoring the TMPRSS2–SPIKE interaction in lysate from cells co-expressing these proteins.The assay was configured in a 384-well-plate format for high-throughput screening with robust assay performance.To enable large-scale compound screening,we further miniaturized the assay into 1536-well ultrahigh-throughput screening(uHTS)format.A pilot screen demonstrated the utilization of the assay for uHTS.Our optimized TR-FRET uHTS assay provides an enabling platform for expanded screening campaigns to discover new classes of small-molecule inhibitors that target the SPIKE and TMPRSS2 protein–protein interaction.Danielle Cicka Qiankun Niu Min Qui Kun Qian Eric Miller Dacheng Fan Xiulei Mo Andrey AIvanov Stefan GSarafianos Yuhong Du Haian Fu 2023Journal of Molecular Cell Biology2023,15,3:0
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