|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021，29，2： | 9 |
| 2 | Identification of CD13,CD107a,and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-de-pendent upregulation显示文摘Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited an increased reactivity with basophils activated by anti-IgE-mediated cross-linking of the high affinity IgE receptor (FcεRI). These include antibod- ies against CD164 (WS-80160, clone N6B6 and WS-80162, clone 67D2), as well as two reagents with previously unknown specificities that were identified as CD13 (WS-80274, clone A8) and CD107a (WS-80280, clone E63-880). The activation patterns followed either the “CD203c-like” or “CD63-like” activation profile. The CD203c profile is characterized by a rapid and significant upregulation (of CD13, CD164, and CD203c), reaching maximum levels after 5- 15 min of stimulation. The phosphoinositide-3-kinase (PI3K)-specific inhibitor wortmannin inhibited the upregulation of these markers whereas 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced a rapid and FcεRI-independent upregulation within 1-2 min. In the CD63 profile, maximum upregulation (of CD63 and CD107a) was detected only after 20-40 min, and upregulation by TPA reached maximum levels after 60 min. In summary, our data identify CD13, CD107a, and CD164 as novel basophil-activation antigens. Based on time kinetics of upregulation, we hypothesize that molecules of the “CD203c group” and the “CD63 group” are linked to two different mechanisms of basophil activation. | Florian HENNERSDORF Stefan FLORIAN Andreas JAKOB Katharina BAUMGRTNER Karoline SONNECK Alfred NORDHEIM Tilo BIEDERMANN Peter VALENT Hans-Jrg BüHRING | 2005 | Cell Research2005，15，5： | 9 |
| 3 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 4 | Wash water in waterworks:contaminants and process options for reclamation显示文摘Reclamation of clean water from filter backwash water was studied through pilot-scale experiments.The pilot plant consisted of clarification,sand-filtration,and ultrafiltration modules in sequence,with a provision to bypass the sand filter.Clean water that conformed to World Health Organization (WHO) guidelines on Potable Quality was reclaimed.Turbidity,aluminum and iron were found to be critical contaminants in process selection and design.Clarification,followed by sand filtration,was found to be the minimum requirement for recycling filter backwash.However,membrane filtration would enhance reclaimed water quality as the membrane acts as an additional barrier against Giardia and Cryptosporidium. | C B Chidambara Raj Tan Ee Kwong Soh Hoo Tiong Paul Stefan Klose | 2008 | Journal of Environmental Sciences2008，20，11： | 4 |
| 5 | Not interferon, but interleukin‐6 controls early gene expression in hepatitis B virus infection显示文摘 | Marianna H?sel Maria Quasdorff Katja Wiegmann Dennis Webb Uta Zedler Mathias Broxtermann Raindy Tedjokusumo Knud Esser Silke Arzberger Carsten J. Kirschning Anja Langenkamp Christine Falk Hildegard Büning Stefan Rose‐John Ulrike Protzer | 2009 | Hepatology2009，，6： | 3 |
| 6 | Small (Sendai Negative) Branch-Duct IPMNs: Not Harmless显示文摘 | Stefan Fritz Miriam Klauss Frank Bergmann Thilo Hackert Werner Hartwig Oliver Strobel Bogata D. Bundy Markus W. Büchler Jens Werner | 2012 | Annals of Surgery2012，，2： | 3 |
| 7 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 8 | Anaplastic pancreatic cancer: Presentation, surgical management, and outcome显示文摘 | Oliver Strobel Werner Hartwig Frank Bergmann Ulf Hinz Thilo Hackert Lars Grenacher Lutz Schneider Stefan Fritz Matthias M. Gaida Markus W. Büchler Jens Werner | 2011 | Surgery2011，，2： | 2 |
| 9 | How should liver hypertrophy be stimulated?A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)and portal vein embolization(PVE)with rescue possibility显示文摘Background:The role of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in comparison to portal vein embolization(PVE)is debated.The aim of this study was to compare successful resection rates(RR)with upfront ALPPS vs.PVE with rescue ALPPS on demand and to compare the hypertrophy of the liver between ALPPS and PVE plus subsequent rescue ALPPS.Methods:A retrospective analysis of all patients treated with PVE for colorectal liver metastasis(CRLM)or ALPPS(any diagnosis,rescue ALPPS included)at five Scandinavian university hospitals during the years 2013-2016 was conducted.A Chi-square test and a Mann-Whitney U test were used to assess the difference between the groups.A successful RR was defined as liver resection without a 90-day mortality.Results:A total of 189 patients were included.Successful RR was in 84.5%of the patients with ALPPS upfront and in 73.3%of the patients with PVE and rescue ALPPS on demand(P=0.080).The hypertrophy of the future liver remnants(FLRs)with ALPPS upfront was 71%(48-97%)compared to 96%(82-113%)after PVE and rescue ALPPS(P=0.010).Conclusions:Upfront ALPPS offers a somewhat higher successful RR than PVE with rescue ALPPS on demand.The sequential combination of PVE and ALPPS leads to a higher overall degree of hypertrophy than upfront ALPPS. | Ernesto Sparrelid Kristina Hasselgren Bård Ingvald Røsok Peter Nørgaard Larsen Nicolai Aagaard Schultz Ulrik Carling Eva Fallentin Stefan Gilg Per Sandström Gert Lindell Bergthor Björnsson | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 2 |
| 10 | Bacterial translocation and infected pancreatic necrosis in acute necrotizing pancreatitis derives from small bowel rather than from colon显示文摘 | Stefan Fritz Thilo Hackert Werner Hartwig Florian Rossmanith Oliver Strobel Lutz Schneider Katja Will-Schweiger Mechthild Kommerell Markus W. Büchler Jens Werner | 2010 | The American Journal of Surgery2010，，1： | 2 |
| 11 | 智能联合收获机——提高性能和效率显示文摘从简单的信息系统到部分自动化操作,联系收割机减轻了机手的作业强度,提高了机具的应用潜力。将来的发展更将实现机组的自动化作业。 | Stefan BTTINGER | 2013 | 农业装备与车辆工程2013，51，6： | 2 |
| 12 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 13 | Serum uric acid as an independent predictor of mortality in patients with angiographically proven cornonary disease显示文摘 | CHRISTOPH B HANS J R STEFAN B | 2002 | Am J Cardiol2002，89，： | 1 |
| 14 | Prevalence of sleep apnea in morbidly obese patients who presented for weight loss surgery evaluation: more evidence for routine screening for ob- structive sleep apnea before weight loss surgery 显示文摘 | Lopez PP Stefan B Schulman CI | 2008 | Am Surg2008，74，9： | 1 |
| 15 | The effects of antitussive treatment of ACE inhibitor - induced cough on therapy compli- ance: A prescription sequence symmetry analysis显示文摘 | Stefan V Pieter B Klaas WD | 2013 | Drug Safe- ty2013，36，6： | 1 |
| 16 | SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information 显示文摘 | Marco B Stefan B Andrew W | 2014 | Nucleic Acids Res2014，42，1： | 1 |
| 17 | Time-dependent attenuator for dynamic range reduction of lidar signals显示文摘 | STEFAN L VOLKER W JENS B | 1997 | Appl Opt1997，36，15： | 1 |
| 18 | Scale-free topology of e-mail networks显示文摘 | Lutz I M Stefan B | 2002 | Phys Rev E2002，66，03： | 1 |
| 19 | Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina显示文摘 | Stefan B Laurence T Christoph B | 2002 | Circulation2002，106，1： | 1 |
| 20 | Quantitative determination of physical and chemical measurands in honey by near-infrared spectrometry显示文摘 | Kaspar R Werner L Stefan B | 2007 | Europe Food Res earc h Technology2007，225，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员