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35篇 您的检索式：作者名="Steinmeyer G"

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	题名	作者	年代	出处	被引量
1	Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs.	Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth	2007	World Journal of Gastroenterology2007，13，48：	4
2	Saturation of the all-optical Kerr effect显示文摘	Brée C Demircan A Steinmeyer G		0，，18：	1
3	Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages显示文摘	Fabri M Stenger S Shin DM Yuk JM Liu PT Realegeno S Lee HM Krutzik SR Schenk M Sieling PA Teles R Montoya D Iyer SS Bruns H Lewinsohn DM Hollis BW Hewison M Adams JS Steinmeyer A Zügel U Cheng G Jo EK Bloom BR Modlin RL		0，，：	1
4	Helium release from aged palladium tritide 显示文摘	ABELL G C MATSON L K STEINMEYER R H	1990	Physical Review B1990，41，2：	1
5	Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenpus oocytes 显示文摘	Jentsch TJ Steinmeyer K Schwarz G	1990	Nature1990，348，：	1
6	Ultra - compact Si -SiO2 microring resonator optical channel dropping filters 显示文摘	Little B E Foresi J S Steinmeyer G	1998	Photonics Technology Letters1998，10，4：	1
7	Ultra-compact Si-SiO2 microring resonator optical channel dropping filters显示文摘	Little B E Foresi J S Steinmeyer G	1998	IEEE Photonics Technology Letters1998，10，4：	1
8	Primary structure of a Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes显示文摘	Jentsch T J Steinmeyer K Schwarz G	1990	Nature1990，348，：	1
9	Semiconductor saturable-absorber mirror-assisted Kerr-lens modelocked Ti : sapphire laser producing pulses in the two-cycle regime 显示文摘	SUTTER D H STEINMEYER G GALLMANN L	1999	Optics Letters1999，24，9：	1
10	Brewster-angled chirped mirrors for high- fidelity dispersion compensation and bandwidths exceeding one optical octave显示文摘	STEINMEYER G	2003	Optics Express2003，11，19：	1
11	Ultra-compact Si- SiO2 microring resonator optical channel dropping filters显示文摘	Little B E Foresi J S Steinmeyer G	1998	IEEE Photon Technol Lett1998，10，4：	1
12	Primary structure of Torpedo marmorata chloride chanel isolated by expression cloning in xenopus oocytes显示文摘	Jentsch TJ Steinmeyer K Schwarz G	1990	Nature1990，348，6301：	1
13	Ultra-compact Si-SiO2 microring resonator optical channel dropping filters显示文摘	Little B Foresi J Steinmeyer G	1998	IEEE Photon Technol Lett1998，10，：	1
14	The inhibitory effects of antirheumatic drugs on the activity of human leukocyte elastase and cathepsin G显示文摘	Steinmeyer G J Kalbhen D A	1996	Inflamm Res1996，45，7：	1
15	Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes显示文摘	Jentsch TJ Steinmeyer K Schwarz G		0，，6301：	1
16	The inhibitory effects of an-tirheumatic drugs on the activity of human leukocyte elastase and cathepsin G 显示文摘	Steinmeyer G J Kalbhen D A	1996	Inflamm Res1996，45，7：	1
17	KCO1 is a component of the slow-vacuolar (SV) ion channel显示文摘	SCHONKNECHT G SPOORMAKER P STEINMEYER R	2002	FEBS Letters2002，511，：	1
18	Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes显示文摘	Jentsch T J Steinmeyer K Schwarz G	1990	Nature1990，348，：	1
19	Frontier in ultrashort pulse generation:pushing the limits in linear and nonlinear optics显示文摘	STEINMEYER G SUTTER D H GALLMANN L	1999	Science1999，286，19：	1
20	Generation of sub-4-fs pulses via compression of a white-light continuum using only chirped mirrors显示文摘	Steinmeyer G Stibenz G	2006	Applied Physics B2006，82，2：	1

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