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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | Biochemical mechanisms for oxygen free radical formation during exercise显示文摘 | Sj?din B Hel sten Westing Y Apple FS | | 0，，04： | 1 |
| 3 | Jrgensen Benchmarking combinedbiological phophorus and nitrogen removel wastewater treatmentprocesses显示文摘 | Krist V Gemaey Sten B | 2004 | Control Engineering Practice2004，12，3： | 1 |
| 4 | Simultaneous monitoring of oil film thickness and temperature in fluid film bearings 显示文摘 | Sergei B Glavatskih a O sten Uusitalo a Daniel J Spohn b | 2001 | Tribology International2001，34，： | 1 |
| 5 | Gastrointestinal delivery of peptide and protein drugs to aquaculture teleosts显示文摘 | Mclean E Rnsholdt B Sten C | 1999 | Aquaculture1999，，177： | 1 |
| 6 | Relating the microstructure of enzyme dispersions in organic solvents to their kinetic behavior显示文摘 | Bracey E Stenning R A Brooker B E | 1998 | Enzyme and Microbial Technology1998，22，3： | 1 |
| 7 | Benchmarking combined biological phosphorus and nitrogen removal wastewater treatment processes 显示文摘 | KRIST V G STEN B J | 2004 | Control Engineering Practice2004，，12： | 1 |
| 8 | Glucose and tolbutamide induce apoptosis in pancreatic-cells: a process dependent on intracellular Ca2+ concentration显示文摘 | Sergei VZ Boris Z Martin K Sten O Per-Olof B | 1998 | J Biol Chem1998，273，33： | 1 |
| 9 | Field testing of a rover guidance,navigation,and control architecture to support a groundice prospecting mission to Mars显示文摘 | Barfoot T Furgale P Stenning B | | 0，，06： | 1 |
| 10 | Analysis of density-inde- pendent equations for determination of moisture content of wheat in the radiofrequency range 显示文摘 | Berbert P A Stenning B C | 1996 | Journal of Agricul- tural Engineering Research1996，65，： | 1 |
| 11 | Non-steroidal antiinflammatory drugs interact with testosterone glucuronidation显示文摘 | Sten T Finel M Ask B | 2009 | Steroids2009，74，12： | 1 |
| 12 | Gastrointestinal delivery of peptide and protein drugs to aquaculture teleosts显示文摘 | Mclean E Rinsholdt B Sten C | 1999 | Aquaculture1999，177，： | 1 |
| 13 | An analytical and experimental study of air lift pump performance显示文摘 | Stenning A H Martin C B | 1968 | Journal Engineering for Power Trans1968，90，： | 1 |
| 14 | A wetness sensor for detecting condensation on tomato plants in greenhouses显示文摘 | Wei Y Q Bailey B J Stenning B C | 1995 | Journal of Agricultural Engineering Research1995，61，3： | 1 |
| 15 | Relating the microstructure of enzyme dispersions in organic solvents to their kinetic behavior显示文摘 | Bracey E Stenning R A Brooker B | 1998 | Enzyme Microb Technol1998，，22： | 1 |
| 16 | On , line moisture measurement of wheat 显示文摘 | BERBERT P A STENNING B C | 1996 | J Agric Engng Res1996，65，： | 1 |
| 17 | Damage mechanisms of a high-Cr single crystal superalloy during thermomechanical fatigue 显示文摘 | Johan J Moverarea B Sten Johanssona | 2010 | Materials Science and Engineering A2010，，527： | 1 |
| 18 | Primary habitual abortions are associated with high frequency of Fac tory V Leiden mutation显示文摘 | W ram sby M L Sten L S B remme K | 2000 | Fertil Steril2000，，745： | 1 |
| 19 | Primary habitual abortions are associated with high frequency of Factory V Leiden mutation显示文摘 | W ram sby M L Sten L S B remme K | 2000 | Fertil Steril2000，45，7： | 1 |
| 20 | Primary habitual abortions are a s sociated with high frequency of Factory V Leiden mutation 显示文摘 | Wram sby M L Sten L S B remme K | 2000 | FertiI Steri12000，，745： | 1 |
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