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| 1 | Relation between mean arterial pressure and renal function in the early phase of shock显示文摘 | JULIE BADIN THIERRY BOULAIN STEPHAN EHRMANN | 2011 | Critical Care2011，15，： | 1 |
| 2 | Fluid challenge: tracking changes in cardiac output with blood pressure monitoring (invasive or non-invasive)显示文摘 | Karim Lakhal Stephan Ehrmann Dominique Perrotin Michel Wolff Thierry Boulain | 2013 | Intensive Care Medicine2013，，11： | 1 |
| 3 | Awake prone positioning for patients with COVID-19-induced acute hypoxemic respiratory failure显示文摘Whereas prone positioning of intubated patients suffering from acute respiratory distress syndrome represents the standard of care,proning non-intubated patients,so-called“awake prone positioning(APP),”has only recently gained popularity and undergone scientific evaluation.In this review,we summarize current evidence on physiological and clinical effects of APP on patients’centered outcomes,such as intubation and mortality,the safety of the technique,factors and predictors of success,practical issues for optimal implementation,and future areas of research.Current evidence supports using APP among patients suffering from acute hypoxemic respiratory failure due to COVID-19 and undergoing advanced respiratory support,such as high-flow nasal cannula,in an intensive care unit setting.Healthcare teams should aim to prone patients at least 8 h daily.Future research should focus on optimizing the tolerance of the technique and comprehensively evaluating benefits in other patient populations. | Yonatan Perez Jian Luo Miguel Ibarra-Estrada Jie Li Stephan Ehrmann | 2022 | Journal of Intensive Medicine2022，2，4： | 1 |
| 4 | Pazopanib-induced posterior reversible encephalopathy syndrome with possible syndrome of inappropriate secretion of antidiuretic hormone: an incidental or pathophysiological association?显示文摘Introduction:Pazopanib is an oral protein kinase inhibitor(PKI)that targets vascular endothelial growth factor(VEGF)receptors,fibroblastic growth factor receptors,platelet-derived growth factor receptors,and stem cell factor that inhibits VEGF-induced cellular proliferation.Pazopanib is approved for use in advanced renal cell carcinoma and subtypes of advanced soft-tissue sarcoma(Deguchi et al.,2018).Major adverse drug reactions of pazopanib include hypertension,high-grade hyponatremia and posterior reversible encephalopathy syndrome(PRES)(Berardi et al.,2016;Deguchi et al.,2018).In clinical trials,few investigations have been conducted to determine the aetiology of PKI-associated hyponatremia,the mechanism remains therefore unknown.Only rare cases of PKI-induced syndrome of inappropriate secretion of antidiuretic hormone(SIADH)(Largeau et al.,2019),and none with pazopanib,have been reported.PRES is a clinical and radiological entity where a bilateral white matter oedema,occurring predominantly in the posterior occipital and parietal lobes,is associated with several neurologic symptoms.Interestingly,a recent review suggests that SIADH could be a symptom of PRES(Largeau et al.,2019).To our knowledge,this is the first case published where pazopanib-induced PRES occurs contemporaneously with possible SIADH. | Jonathan Wong So Bérenger Largeau Frédérique Beau-Salinas Stephan Ehrmann Christophe Magni Jérome Meunier | 2020 | Neural Regeneration Research2020，15，6： | 0 |
| 5 | 无创袖带测压在追踪低血压及有创动脉压动态变化方面的表现分析显示文摘背景休克患者一般建议实施动脉置管监测。然而,这项有创操作有一定风险,而且可能延误其他的急救操作。本研究针对袖带无创测压(N1BP)在有创平均动脉血压(MAP)低于65mmHg以及给予心血管干预后MAP升高时的追踪能力进行探讨。方法这项前瞻性研究在3个重症监护室进行,选取循环衰竭的成年患者,依次进行腿抬高45°、补液300ml、再次补液200ml3种处理。每个试验阶段分别测量4个有创和无创MAP值。结果111例患者(50例感染性休克、15例心源性休克和46例其他原因休克)中,当有创MAP小于65iilmHg时,NIBP可以准确反映患者血压:受试者操作特征曲线(ROC)下面积(AUC)为0.90(95%可信区间:0.71—1),阳性似然比(LHR)为7.7(95%可信区间:5.4—11),阴性似然比为0.31(95%可信区间:0.22—0.44)(界点65mmHg)。NIBP可以有效判断患者MAP10%以上的上升:AUCh0.95(95%可信区间:0.92—0.96),阳性LHR为25.7(95%可信区间:10.8—61.4),阴性LHR为0.26(95%可信区间:0.2—0.34)(界点10%)。结论NIBP对于低血压有很好的辨别能力,如果取4次测量平均值的话,甚至可以比有创血压更好地反映MAP的变化。 | Karim Lakhal Stephan Ehrmann Isabelle Runge Annick Legras Pierre-Francois Dequin Emmanuelle Mercier Michel Wolff Bernard Regnier Thierry Boulain 王佳琬(译) 岳云(校) | 2010 | 麻醉与镇痛2010，，6： | 0 |
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