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| 1 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 2 | Long-Term Follow-Up of Biopsy-Proven Viral Myocarditis显示文摘 | Stefan Grün Julia Schumm Simon Greulich Anja Wagner Steffen Schneider Oliver Bruder Eva-Maria Kispert Stephan Hill Peter Ong Karin Klingel Reinhardt Kandolf Udo Sechtem Heiko Mahrholdt | 2012 | Journal of the American College of Cardiology2012，，18： | 2 |
| 3 | Utility of Absolute and Relative Changes in Cardiac Troponin Concentrations in the Early Diagnosis of Acute Myocardial Infarction显示文摘 | Tobias Reichlin Affan Irfan Raphael Twerenbold Miriam Reiter Willibald Hochholzer Hanna Burkhalter Stefano Bassetti Stephan Steuer Katrin Winkler Federico Peter Julia Meissner Philip Haaf Mihael Potocki Beatrice Drexler Stefan Osswald Christian Mueller | 2011 | Circulation2011，，2： | 2 |
| 4 | Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn’s disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis显示文摘 | Julia Seiderer Fabian Schnitzler Stephan Brand Tanja Staudinger Simone Pfennig Karin Herrmann Katrin Hofbauer Julia Dambacher Cornelia Tillack Michael Sackmann Burkhard G?ke Peter Lohse Thomas Ochsenkühn | 2006 | Scandinavian Journal of Gastroenterology2006，，12： | 1 |
| 5 | Spatial variability of soil properties affected by grazing intensity in InnerMongolia grassland显示文摘 | Ying Z Stephan P Julia K | 2007 | Ecological Modelling2007，205，： | 1 |
| 6 | A user perspective on future cloud-based services for Big Earth data显示文摘Cloud-based services introduce a paradigm shift in how users access,process and analyse Big Earth data.A key challenge is to align the current state of how users access,process and analyse the data with trends and roadmaps large data organisations layout.In addition,due to the increased availability of open data,a more diverse user base wants to take advantage of Earth science data leading to new user requirements.We run a web-based survey among Big Earth data users to better understand the motivation to migrate to cloud-based services as well as the challenges and opportunities that might arise.Results show an overall interest in moving to cloud-based services but air an insufficient literacy in cloud systems and a lack of trust due to security concerns and opacity of emerging costs.These gaps demand efforts on three levels.First,cloud services shall be targeted at intermediate users instead of policy-and decision-makers and over-engineered systems with a high level of abstraction should be avoided.Second,more substantial capacity-building efforts are required to decrease the existing gap in cloud skills and uptake.Third,a cloud certification mechanism could help in building up overall trust in cloud-based services. | Julia Wagemann Stephan Siemen Bernhard Seeger Jörg Bendix | 2021 | International Journal of Digital Earth2021，14，12： | 1 |
| 7 | Real time scheduling of workflow management systems based on a p-time Petri net model with hybrid resources 显示文摘 | Stephane Julia Fernanda Francielle de Oliveira Robert Valette | 2008 | Simulation Modelling Practice and Theory2008，16，4： | 1 |
| 8 | Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4显示文摘 | Miriam E. Jaax Krystin Krauel Thomas Marschall Sven Brandt Julia Gansler Birgitt Fürll Bettina Appel Silvia Fischer Stephan Block Christiane A. Helm Sabine Müller Klaus T. Preissner Andreas Greinacher | 2013 | Blood2013，，： | 1 |
| 9 | SJWD15012600002617显示文摘 | Giridhar Kanuri Ruth Ladurner Julia Skibovskaya Astrid Spruss Alfred K?nigsrainer Stephan C. Bischoff Ina Bergheim | 2015 | Liver Int2015，，2： | 1 |
| 10 | Real-time scheduling of batch systems using Petri nets and linear logic显示文摘 | Michel dos Santos Soares Stephane Julia Jos Vrancken | 2008 | Journal of Systems and Software2008，81，11： | 1 |
| 11 | The Surgical Treatment of the Lumbar Disc Prolapse: Nucleotomy With Additional Transpedicular Dynamic Stabilization Versus Nucleotomy Alone显示文摘 | Michael Putzier Sascha V. Schneider Julia F. Funk Stephan W. Tohtz Carsten Perka | 2005 | Spine2005，，5： | 1 |
| 12 | Redox-dependent fractionation of iron isotopes in suspensions of a groundwater-influenced soil显示文摘 | Stephan Schuth Julia Hurra? Carsten Münker Tim Mansfeldt | 2014 | Chemical Geology2014，，： | 1 |
| 13 | Meoradiand Personalitytraits and knowledge sharing显示文摘 | Kurt Matzlera Birgit Renslb Julia Müllerb Stephan Hertingc Todd A | 2008 | Journal of Economic Psychology2008，29，： | 1 |
| 14 | Phase I Pharmacokinetic and Pharmacodynamic Study of Pazopanib in Children With Soft Tissue Sarcoma and Other Refractory Solid Tumors: A Children’s Oncology Group Phase I Consortium Report显示文摘 | Julia L. Glade Bender Alice Lee Joel M. Reid Sylvain Baruchel Timothy Roberts Stephan D. Voss Bing Wu Charlotte H. Ahern Ashish M. Ingle Pamela Harris Brenda J. Weigel Susan M. Blaney | 2013 | Journal of Clinical Oncology2013，，24： | 1 |
| 15 | Personality traits and knowledge sharing显示文摘 | Kurt Matzler Birgit Renzl Julia Müller Stephan Herting Todd A. Mooradian | 2007 | Journal of Economic Psychology2007，，3： | 1 |
| 16 | Shock Efficacy of Subcutaneous Implantable Cardioverter-Defibrillator for Prevention of Sudden Cardiac Death: Initial Multicenter Experience显示文摘 | Ali Aydin Friederike Hartel Michael Schlüter Christian Butter Julia K?be Martin Seifert Nils Gosau Boris Hoffmann Matthias Hoffmann Eik Vettorazzi Iris Wilke Karl Wegscheider Hermann Reichenspurner Lars Eckardt Daniel Steven Stephan Willems | 2012 | Circulation: Arrhythmia and Electrophysiology2012，，5： | 1 |
| 17 | Improving ITS sequence data for identification of plant pathogenic fungi显示文摘Plant pathogenic fungi are a large and diverse assemblage of eukaryotes with substantial impacts on natural ecosystems and human endeavours.These taxa often have complex and poorly understood life cycles,lack observable,discriminatory morphological characters,and may not be amenable to in vitro culturing.As a result,species identification is frequently difficult.Molecular(DNA sequence)data have emerged as crucial information for the taxonomic identification of plant pathogenic fungi,with the nuclear ribosomal internal transcribed spacer(ITS)region being the most popular marker.However,international nucleotide sequence databases are accumulating numerous sequences of compromised or low-resolution taxonomic annotations and substandard technical quality,making their use in the molecular identification of plant pathogenic fungi problematic.Here we report on a concerted effort to identify high-quality reference sequences for various plant pathogenic fungi and to re-annotate incorrectly or insufficiently annotated public ITS sequences from these fungal lineages.A third objective was to enrich the sequences with geographical and ecological metadata.The results-a total of 31,954 changes-are incorporated in and made available through the UNITE database for molecular identification of fungi(http://unite.ut.ee),including standalone FASTA files of sequence data for local BLAST searches,use in the next-generation sequencing analysis platforms QIIME and mothur,and related applications.The present initiative is just a beginning to cover the wide spectrum of plant pathogenic fungi,and we invite all researchers with pertinent expertise to join the annotation effort. | R.Henrik Nilsson Kevin D.Hyde Julia Pawlowska Martin Ryberg Leho Tedersoo Anders Bjornsgard Aas Siti A.Alias Artur Alves Cajsa Lisa Anderson Alexandre Antonelli A.Elizabeth Arnold Barbara Bahnmann Mohammad Bahram Johan Bengtsson-Palme Anna Berlin Sara Branco Putarak Chomnunti Asha Dissanayake Rein Drenkhan Hanna Friberg Tobias Guldberg Froslev Bettina Halwachs Martin Hartmann Beatrice Henricot Ruvishika Jayawardena Ari Jumpponen Havard Kauserud Sonja Koskela Tomasz Kulik Kare Liimatainen Bjorn D.Lindahl Daniel Lindner Jian-Kui Liu Sajeewa Maharachchikumbura Dimuthu Manamgoda Svante Martinsson Maria Alice Neves Tuula Niskanen Stephan Nylinder Olinto Liparini Pereira Danilo Batista Pinho Teresita M.Porter Valentin Queloz Taavi Riit Marisol Sánchez-García Filipe de Sousa Emil Stefańczyk Mariusz Tadych Susumu Takamatsu Qing Tian Dhanushka Udayanga Martin Unterseher Zheng Wang Saowanee Wikee Jiye Yan Ellen Larsson Karl-Henrik Larsson Urmas Koljalg Kessy Abarenkov | 2014 | Fungal Diversity2014，，4： | 1 |
| 18 | Modeling grazing effects on coupled water and heat fluxes in Inner Mongolia grassland显示文摘 | Ying Zhao Stephan Peth Rainer Horn Julia Krümmelbein Bettina Ketzer Yingzhi Gao Jose Doerner Christian Bernhofer Xinhua Peng | 2010 | Soil & Tillage Research2010，，2： | 1 |
| 19 | Nodular regenerative hyperplasia: a reversible entity associated with azathioprine therapy显示文摘 | Julia Seiderer Christoph J. Zech Joachim Diebold Stefan O. Schoenberg Stephan Brand Cornelia Tillack Burkhard G?ke Thomas Ochsenkühn | 2006 | European Journal of Gastroenterology & Hepatology2006，，5： | 1 |
| 20 | Blastic Plasmacytoid Dendritic Cell Neoplasms: Clinico-immunohistochemical Correlations in a Series of 91 Patients显示文摘 | Fanny Julia Stephane Dalle Gerard Duru Brigitte Balme Béatrice Vergier Nicolas Ortonne Marie D. Vignon-Pennamen Valérie Costes-Martineau Laurence Lamant Sophie Dalac Claire Delattre Pierre Déchelotte Philippe Courville Agnès Carlotti Anne De Muret Sylvie | 2014 | The American Journal of Surgical Pathology2014，，5： | 1 |
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