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| 1 | Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date显示文摘Chronic lymphocytic leukemia(CLL) is the most common leukemia in the western world. Despite significantadvances in therapy over the last decade CLL remains incurable. Current front-line therapy often consists of chemoimmunotherapy-based regimens, most commonly the fludarabine, cyclophosphamide plus rituximab combination, but rates of relapse and refractory disease are high among these patients. Several key signaling pathways are now known to mediate the survival and proliferation of CLL cells in vivo, the most notable of which are the pathways mediated by the B-cell receptor(BCR) and cytokine receptors. A better understanding of the pathogenesis of the disease, the underlying biology of the CLL-cell and the roles of the tumour microenvironment has provided the rationale for trials of a range of novel, more targeted therapeutic agents. In particular, clinical trials of ibrutinib and idelalisib, which target the Brutons tyrosine kinase and the delta isoform of phosphoinositol-3 kinase components of the BCR signaling pathway respectively, have shown extremely promising results. Here we review the current literature on the key signaling pathways and interactions of CLL cells that mediate the survival and proliferation of the leukemic cells. For each we describe the results of the recent clinical trials and in vitro studies of novel therapeutic agents. | Kyle Crassini Stephen P Mulligan O Giles Best | 2015 | World Journal of Clinical Cases2015，3，8： | 5 |
| 2 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | 2007 (9558)2007，，9558： | 3 |
| 3 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | The Lancet . 2007 (9558)2007，，9558： | 2 |
| 4 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | The Lancet2007，，9558： | 2 |
| 5 | Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘 | David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey | 2008 | Hypertension2008，，6： | 1 |
| 6 | Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘 | David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey | 2008 | Hypertension2008，，6： | 1 |
| 7 | The Doppler Assessment in multiple pregnancy randomised controlled trial of ultrasound biometry versus umbilical artery Doppler ultrasound and biometry in twin pregnancy显示文摘 | Warwick Giles Andrew Bisits Stephen O’Callaghan Andrew Gill | 2003 | BJOG: An International Journal of Obstetrics and Gynaecology2003，，6： | 1 |
| 8 | Angiogenesis in normal tissue adjacent to colon cancer显示文摘 | Stephen H.Fox Giles F.Whalen M. MelindaSanders Joseph A.Burleson KimJennings ScottKurtzman DonaldKreutzer | 1998 | Oncol1998，，4： | 1 |
| 9 | REPRINT Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘 | David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey | 2008 | Circulation2008，，25： | 1 |
| 10 | REPRINT Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘 | David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey | 2008 | Circulation2008，，25： | 1 |
| 11 | Remote Bolted Flange Connection Ap- paratus and Methods of Operation Thereof显示文摘 | Giles John Stephen | 2001 | Stoh Offshore Limited2001，，9： | 1 |
| 12 | Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘 | David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey | 2008 | Hypertension2008，，6： | 1 |
| 13 | Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘 | David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey | 2008 | Hypertension2008，，6： | 1 |
| 14 | Identification of new genetic risk factors for prostate cancer显示文摘有证据,到前列腺癌症(PCa ) 的基因倾向的实质的部分可能由于被染色体宽的协会研究发现的更低的外显率基因。我们最近进行了如此的研究,染色体的七个新区域连接了到 PCa 风险被识别了。三这些 loci 包含候选人危险性基因:MSMB, LMTK2 和 KLK2/3。MSMB 和 KLK2/3 基因可能为 PCa 屏蔽,和 LMTK2 基因是有用的可能提供一个潜在的治疗学的目标。和从另外的组的结果,现在有 23 germline 被报导了的基因变体。这些结果有潜力被发展进基因测试。然而,我们认为测试出售到公众是早熟的,当 PCa 风险不能在这个阶段和要发展的适当屏蔽协议需要充分被评估。后续确认学习,以及学习探索基因侧面测试的心理含意,将重要在以前推出进保健。 | Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O'Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons' Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles | 2009 | Asian Journal of Andrology2009，11，1： | 1 |
| 15 | Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study显示文摘 | Laura García-álvarez Matthew TG Holden Heather Lindsay Cerian R Webb Derek FJ Brown Martin D Curran Enid Walpole Karen Brooks Derek J Pickard Christopher Teale Julian Parkhill Stephen D Bentley Giles F Edwards E Kirsty Girvan Angela M Kearns Bruno Pichon | 2011 | The Lancet Infectious Diseases2011，，8： | 1 |
| 16 | Therapeutic approaches and drug-resistance in chronic lymphocytic leukaemia显示文摘The treatment of chronic lymphocytic leukaemia has been revolutionised in recent years,first by the introduction of chemoimmunotherapy regimens and subsequently by the development of drugs,including ibrutinib,idelalisib and venetoclax,that target components of the B-cell receptor signalling pathway or B-cell lymphoma 2 family of proteins.Despite high initial response rates in patients treated with chemoimmunotherapy or targeted agents,a significant proportion of patients relapse with progressive and refractory disease.In a subset of these patients,drug resistance has been associated with specific genetic lesions or activation of alternate pro-survival pathways.However,the mechanisms that confer drug resistance in the remainder of the patients with refractory disease have yet to be fully elucidated.In this review,we discuss our current understanding of the mechanics of drug resistance in chronic lymphocytic leukaemia and describe how this knowledge may aid in rationalising future treatment strategies to prevent the development of refractory or aggressive transformation of the disease. | Narjis Fatima Kyle R.Crassini Lauren Thurgood Yandong Shen Richard I.Christopherson Bryone Kuss Stephen P.Mulligan Oliver Giles Best | 2020 | Cancer Drug Resistance2020，3，3： | 0 |
| 17 | Femoral lengthening in young patients:An evidence-based comparison between motorized lengthening nails and external fixation显示文摘BACKGROUND Femoral lengthening is a procedure of great importance in the treatment of congenital and acquired limb deficiencies.Technological advances have led to the latest designs of fully implantable motorized intramedullary lengthening nails.The use of these nails has increased over the last few years.AIM To review and critically appraise the literature comparing the outcome of femoral lengthening in children using intramedullary motorized lengthening nails to external fixation.METHODS Electronic databases(MEDLINE,CINAHL,EMBASE,Cochrane)were systematically searched in November 2019 for studies comparing the outcome of femoral lengthening in children using magnetic lengthening nails and external fixation.The outcomes included amount of gained length,healing index,complications and patient reported outcomes.RESULTS Of the 452 identified studies,only two(retrospective and non-randomized)met the inclusion criteria.A total of 91 femora were included.In both studies,the age of patients treated with nails ranged from 15 to 21 years compared to 9 to 15 years for patients in the external fixation group.Both devices achieved the target length.Prevalence of adverse events was less in the nail(60%-73%)than in the external fixation(81%-100%)group.None of the studies presented patient reported outcomes.CONCLUSION The clinical effectiveness of motorized nails is equivalent or superior to external fixation for femoral lengthening in young patients.The available literature is limited and does not provide evidence on patient quality of life or cost effectiveness of the interventions. | Mohamed Hafez Nicolas Nicolaou Amaka C Offiah Stephen Giles Sanjeev Madan James A Fernandes | 2021 | World Journal of Orthopedics2021，12，11： | 0 |
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