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5篇 您的检索式:作者名="Stephen Vanner"
    题名 作者 年代 出处 被引量
1Split-dose administration of a dual-action, low-volume bowel cleanser for colonoscopy: the SEE CLEAR I study显示文摘Douglas K. Rex Philip O. Katz Gerald Bertiger Stephen Vanner Lawrence C. Hookey Vivian Alderfer Raymond E. Joseph 2013Gastrointestinal Endoscopy2013,,1:2
2Increasing pain sensation to repeated esophageal balloon distension in patients with chest pain of undetermined etiology显示文摘Dr. William G. Paterson MD Hua Wang MD Stephen J. Vanner MD 1995Digestive Diseases and Sciences1995,,6:1
3The safety profile of oral sodium phosphate for colonic cleansing before colonoscopy in adults显示文摘Lawrence C. Hookey William T. Depew Stephen Vanner 2002Gastrointestinal Endoscopy2002,,6:1
4The safety profile of oral sodium phosphate for colonic cleansing before colonoscopy in adults显示文摘Lawrence C. Hookey William T. Depew Stephen Vanner 2002Gastrointestinal Endoscopy2002,,6:1
5Munc18/SNARE proteins’ regulation of exocytosis in guinea pig duodenal Brunner’s gland acini显示文摘AIM: To examine the molecular mechanism of exocytosis in the Brunner’s gland acinar cell. METHODS: We used a submucosal preparation of guinea pig duodenal Brunner’s gland acini to visualize the dilation of the ductal lumen in response to cholinergic stimulus. We correlated this to electron microscopy to determine the extent of exocytosis of the mucin-filled vesicles. We then examined the behavior of SNARE and interacting Munc18 proteins by confocal microscopy. RESULTS: One and 6 μmol/L carbachol evoked a dose- dependent dilation of Brunner’s gland acini lumen, which correlated to the massive exocytosis of mucin. Munc18c and its cognate SNARE proteins Syntaxin-4 and SNAP-23 were localized to the apical plasma membrane, and upon cholinergic stimulation, Munc18c was displaced into the cytosol leaving Syntaxin-4 and SNAP-23 intact. CONCLUSION: Physiologic cholinergic stimulation induces Munc18c displacement from the Brunner’s gland acinar apical plasma membrane, which enables apical membrane Syntaxin-4 and SNAP-23 to form a SNARE complex with mucin-filled vesicle SNARE proteins to affect exocytosis.Laura I Cosen-Binker Gerry P Morris Stephen Vanner Herbert Y Gaisano 2008World Journal of Gastroenterology2008,14,15:0
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