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| 1 | Active earth pressure acting on retaining wall considering anisotropic seepage effect显示文摘This paper presents a general solution for active earth pressure acting on a vertical retaining wall with a drainage system along the soil-structure interface. The backfill has a horizontal surface and is composed of cohesionless and fully saturated sand with anisotropic permeability along the vertical and horizontal directions. The extremely unfavourable seepage flow on the back of the retaining wall due to heavy rainfall or other causes will dramatically increase the active earth pressure acting on the retaining walls, increasing the probability of instability. In this paper, an analytical solution to the Laplace differential governing equation is presented for seepage problems considering anisotropic permeability based on Fourier series expansion method. A good correlation is observed between this and the seepage forces along a planar surface generated via finite element analysis. The active earth pressure is calculated using Coulomb's earth pressure theory based on the calculated pore water pressures. The obtained solutions can be degenerated into Coulomb's formula when no seepage exists in the backfill. A parametric study on the influence of the degree of anisotropy in seepage flow on the distribution of active earth pressure behind the wall is conducted by varying ratios of permeability coefficients in the vertical and horizontal directions,showing that anisotropic seepage flow has a prominent impact on active earth pressure distribution. Other factors such as effective internal friction angle of soils and soil/wall friction conditions are also considered. | HU Zheng YANG Zhong-xuan Stephen Philip WILKINSON | 2017 | Journal of Mountain Science2017，14，6： | 4 |
| 2 | MICP as a potential sustainable technique to treat or entrap contaminants in the natural environment:A review显示文摘In the last two decades,developments in the area of biomineralization has yielded promising results making it a potentially environmentally friendly technique for a wide range of applications in engineering and wastewater/heavy metal remediation.Microbially Induced Carbonate Precipitation(MICP)has led to numerous patented applications ranging from novel strains and nutrient sources for the precipitation of biominerals.Studies are being constantly published to optimize the process to become a promising,cost effective,ecofriendly approach when compared with the existing traditional remediation technologies which are implemented to solve multiple contamination/pollution issues.Heavy metal pollution still poses a major threat towards compromising the ecosystem.The removal of heavy metals is of high importance due to their recalcitrance and persistence in the environment.In that perspective,this paper reviews the current and most significant discoveries and applications of MICP towards the conversion of heavy metals into heavy metal carbonates and removal of calcium from contaminated media such as polluted water.It is evident from the literature survey that although heavy metal carbonate research is very effective in removal,is still in its early stages but could serve as a solution if the microorganisms are stimulated directly in the heavy metal environment. | Adharsh Rajasekar Stephen Wilkinson Charles K.S.Moy | 2021 | Environmental Science and Ecotechnology2021，，2： | 2 |
| 3 | Dietary manipulation of fatty acid composition in lamb meat and its effect on the volatile aroma compounds of grilled lamb显示文摘 | J. Stephen Elmore Sarah L. Cooper Michael Enser Donald S. Mottram Liam A. Sinclair Robert G. Wilkinson Jeffrey D. Wood | 2004 | Meat Science2004，，： | 1 |
| 4 | Hepatocellular ballooning in NASH显示文摘 | Stephen Caldwell Yoshihiro Ikura Daniela Dias Kosuke Isomoto Akito Yabu Christopher Moskaluk Patcharin Pramoonjago Winsor Simmons Harriet Scruggs Nicholas Rosenbaum Timothy Wilkinson Patsy Toms Curtis K. Argo Abdullah M.S. Al-Osaimi Jan A. Redick | 2010 | Journal of Hepatology2010，，4： | 1 |
| 5 | Investigations of the effects of particle morphology on granular material behaviors using a multi-sphere approach显示文摘This article studies the influences of particle morphology on the behaviors of granular materials at both macroscopic and microscopic levels based on the discrete element method(DEM).A set of numerical tests under drained triaxial compression was performed by controlling two morphological descriptors,i.e.ratio of the smallest to the largest pebble diameter,x,and the maximum pebbleepebble intersection angle,b.These descriptors are vital in generating particle geometry and surface textures.It was found that the stress responses of all assemblies exhibited similar behavior and showed post-peak strainsoftening.The normalized stress ratio and volumetric strains flatten off and tended to reach a steady value after an axial strain of 40%.While the friction angles at peak state varied with different morphological descriptors,the friction angles at critical state showed no significant variation.Moreover,evolution of the average coordination numbers showed a dramatic exponential decay until an axial strain of about 15%after which it stabilized and was unaffected by further increase of axial strain.In addition,stress ratio q/p and strong fabric parameter fs d=fs m were found to follow an approximately linear relationship for each assembly.These findings emphasized the significance of the influences of particle morphology on the macroscopic and microscopic responses of granular materials. | Shiva Prashanth Kumar Kodicherla Guobin Gong Lei Fan Stephen Wilkinson Charles K.S.Moy | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，6： | 1 |
| 6 | Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity显示文摘 | Kevin M. Foote Andrew A. Mortlock Nicola M. Heron Frédéric H. Jung George B. Hill Georges Pasquet Madeleine C. Brady Stephen Green Simon P. Heaton Sarah Kearney Nicholas J. Keen Rajesh Odedra Stephen R. Wedge Robert W. Wilkinson | 2008 | Bioorganic & Medicinal Chemistry Letters2008，，6： | 1 |
| 7 | Dielectric Barrier Discharge Plasma Actuators for Flow Control显示文摘 | TTiomas C Corke C Lon Enloe Stephen P Wilkinson | 2010 | The Annual Review of Fluid Mechanics2010，42，： | 1 |
| 8 | A Modified Incremental Shuttle Running Speed and the Prediction of Maxygen Uptak显示文摘 | DAVID M WILKINSON JOANNE L FALLOWFIELD STEPHEN D MYERS | 1999 | J Sports Sci1999，17，： | 1 |
| 9 | Discrete element modelling of strength and critical state characteristics of granular materials under axial compression and axial extension stress path tests显示文摘The critical state soil mechanics(CSSM)framework has been widely used across a range of problems in geomechanics involving complex loading conditions.However,the uniqueness of the critical state has been disputed for many years and it remains a controversial issue.Motivated by previous investigations,a series of discrete element method(DEM)simulations were performed under both axial compression(AC)and axial extension(AE)stress paths.All samples were isotropically compressed at varying mean normal effective stresses(confining pressures)and sheared to a large axial strain of approximately 60%.It is found that there exist unique values of critical void ratios and stress ratios under critical state,which are independent of the samples’initial packings but dependent on stress paths.And the critical strength(stress ratio)for the AC stress path tests is higher than that for the AE stress path.The critical state lines(CSLs)are found to path-dependent but unique for each stress path.A unique linear relationship between the critical coordination numbers and critical void ratios is identified under the AC and AE stress paths respectively,but such a relationship depends on the stress paths.It is also found that there exist unique values of microscopic parameters in terms of deviator fabric under critical state,which are independent of the samples’initial packings but dependent on stress paths.All these simulation results lead to the conclusion of non-uniqueness of CSLs from both macroscopic and microscopic viewpoints. | Shiva Prashanth Kumar Kodicherla Guobin Gong Lei Fan Stephen Wilkinson Charles K.S.Moy | 2021 | Particuology2021，19，3： | 1 |
| 10 | Differential in vitroregula tion by glucocorticoids of monocyte-derived cytokine generationin gl ucocorticoid resistant bronchial asthma 显示文摘 | Stephen J L James R W Wilkinson G M | 1993 | Am Rev Respir Dis1993，147，： | 1 |
| 11 | A Modified Incremental Shuttle Run Test for the Determination of Peak Shuttle Running Speed and the Prediction of Maximal Oxygen Uptake显示文摘 | DAVID M WILKINSON JOANNE L FALLOWFIELD STEPHEN D MYERS | 1999 | J Sports Sci1999，17，： | 1 |
| 12 | Biliary sludge: can ultrasound reliably detect the presence of crystals in bile?显示文摘 | Louise S. Wilkinson Tanya S. Levine David Smith Stephen J.D. Chadwick | 1996 | European Journal of Gastroenterology & Hepatology1996，，10： | 1 |
| 13 | A UNILATERAL URETERAL OBSTRUCTION MOUSE MODEL IS APPLIED TO INVESTIGATE THE PATHOPHYSIOLOGY OF OBSTRUCTED URETERS显示文摘 | Kwadwo Owusu-Ofori Eric Wilkinson William S Mellon Stephen Y Nakada | 2009 | The Journal of Urology2009，，4： | 1 |
| 14 | Identification of new genetic risk factors for prostate cancer显示文摘有证据,到前列腺癌症(PCa ) 的基因倾向的实质的部分可能由于被染色体宽的协会研究发现的更低的外显率基因。我们最近进行了如此的研究,染色体的七个新区域连接了到 PCa 风险被识别了。三这些 loci 包含候选人危险性基因:MSMB, LMTK2 和 KLK2/3。MSMB 和 KLK2/3 基因可能为 PCa 屏蔽,和 LMTK2 基因是有用的可能提供一个潜在的治疗学的目标。和从另外的组的结果,现在有 23 germline 被报导了的基因变体。这些结果有潜力被发展进基因测试。然而,我们认为测试出售到公众是早熟的,当 PCa 风险不能在这个阶段和要发展的适当屏蔽协议需要充分被评估。后续确认学习,以及学习探索基因侧面测试的心理含意,将重要在以前推出进保健。 | Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O'Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons' Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles | 2009 | Asian Journal of Andrology2009，11，1： | 1 |
| 15 | Colonyzer: automated quantification of micro-organism growth characteristics on solid agar显示文摘 | Conor Lawless Darren J Wilkinson Alexander Young Stephen G Addinall | 2010 | BMC Bioinformatics2010，，11： | 1 |
| 16 | 基于离散元的砂土在不同应力路径和剪切模式下的强度和临界状态行为显示文摘本文通过离散元模拟的方法研究了砂土在不同轴对称应力路径和剪切模式下的强度和临界状态行为。其中,应力路径包括轴向压缩和轴向拉伸,而剪切模式包括常规三轴和恒定平均应力三轴。试样分为松砂和密砂两种,初始围压范围控制在100~900 kPa。当轴向应变(绝对值)接近45%时,所有样品均达到临界状态。模拟结果表明在相同围压下,偏应力的临界状态值是唯一的,与初始密度无关,但与应力路径有关:临界状态下轴向压缩的偏应力通常大于轴向拉伸的偏应力。应力比在临界状态下的值与剪切模式和围压均无关,但取决于应力路径。在围压一定的条件下,摩擦角在临界状态下具有唯一性,且不受剪切模式、应力路径和初始密度的影响,这表明Mohr-Coulomb准则(在轴对称条件下等效于Matsuoka准则)是有效的临界状态强度准则。在围压和剪切方式一定的条件下,孔隙率在临界状态下的值与初始密度无关。在临界状态下,不同试样机械配位数的差异是由平均应力的变化所引起的。 | 朱旻奕 龚国斌 张雪 夏骏 MOY Charles-K.S. WILKINSON Stephen | 2023 | Journal of Central South University2023，30，6： | 0 |
| 17 | DEM simulations of critical state behaviour of granular materials under various drained triaxial stress path tests显示文摘The present study investigates the critical state behaviour of granular assemblies composed of clumped particles under four different drained axisymmetric triaxial stress paths,using the discrete element method(DEM).A series of numerical samples were prepared at initial states with different density indexes(1D)and different initial confining pressures(ρ′0).These samples were sheared to large strains,at which constant stresses and volumes were maintained to reach the critical state.The evolution of stress ratio under the same loading mode(for the same intermediate principal stress ratio,b)is shown to yield an almost identical behaviour independent of stress paths,whereas the stress-strain response depends on the stress paths.Four different axisymmetric stress paths all share the same unique friction angle at critical state,indicating the Mohr-Coulomb failure criterion is the appropriate critical state strength criterion,which is at least true for the axisymmetric stress conditions.A unique coordination number(CN)is achieved at the critical state for a given po,which is independent of the stress path.The critical state CN is found to increase with the increase in po,which could be attributed to the decrease in the critical state void ratio(ec)as mean effective stress(ρ′0)increases.Interestingly,a unique linear functional relationship is found between the critical state values of cN and ec,and a unique polynomial functional relationship is found between the critical state values of CN andρ′.These functional relationships indicate no dependency on the stress paths or loading modes,thus characterizing unique features at critical states at both macroscopic and microscopic levels for a given type of granular material. | Shiva Prashanth Kumar Kodicherla Guobin Gong Stephen Wilkinson | 2023 | Particuology2023，，10： | 0 |
| 18 | When is An Embargo not An Embargo: Five Decades of Successful Failure in US-Cuba Policy显示文摘 | Stephen Wilkinson | 2014 | International Relations and Diplomacy2014，2，6： | 0 |
| 19 | DEM investigation of strength and critical state behaviours of granular materials under true triaxial loadings显示文摘This paper investigates the strength and critical state(CS)behaviours of granular materials via DEM simulations of true triaxial drained tests under three different loading modes including constant b(in-termediate stress ratio)tests with constantσ'1(major principal stress),constant p(mean pressure)and constantσ'3(minor principal stress)respectively.To this end,a series of samples are generated with the same particle size distribution,and with the confining stresses ranging from 100 kPa to 900 kPa.The CS is achieved for all samples.Both the macroscopic behaviours and the microscopic behaviours are examined and compared considering different loading modes,confining stresses and intermediate stress ratios(b).The critical state lines(CSLs)are found to be unique and independent of the loading modes,but dependent on the b values.The CSLs with b=0 and b=1 form the two boundaries of CSLs respectively beyond which CSLs under all other b tests cannot go beyond.Six different strength criteria are examined and compared in terms of both peak and CS failures.The Mohr-Coulomb strength criterion is found to be only suitable for axisymmetric loading conditions.The Lade-Duncan criterion is only suitable for describing peak strengths,which is dependent on the loading modes and confining stresses.The Satake criterion and Matsuoka-Nakai criterion are the more appropriate strength criteria for describing CS failures,indicating that the CS values of both the Satake parameter and the Matsuoka-Nakai parameter describe an inherent property that characterizes the CS failure for a given type of soil.The CS mechanical coordination number is fitted by a curved line for a given b value,which is unique regardless of the loading modes.The peak and CS values of both major and minor principal fabric tensors decrease with increasing b values,while they increase with increasing b values for the intermediate principal fabric tensor. | Minyi Zhu Guobin Gong Jun Xia Stephen Wilkinson | 2024 | Particuology2024，85，2： | 0 |
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