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| 1 | Legalon-SIL downregulates HCV core and NS5A in human hepatocytes expressing full-length HCV显示文摘AIM: To determine the effect of Legalon-SIL (LS) on hepatitis C virus (HCV) core and NS5A expression and on heme oxygenase-1 (HMOX-1) and its transcriptional regulators in human hepatoma cells expressing full length HCV genotype 1b. METHODS: CON1 cells were treated with 50 μmol/L or 200 μmol/L LS. Cells were harvested after 2, 6 and 24 h. HCV RNA and protein levels were determined by quantitative real-time polymerase chain reaction and Western blotting, respectively. RESULTS: HCV RNA (core and NS5A regions) wasdecreased after 6 h with LS 200 μmol/L (P < 0.05). Both 50 and 200 μmol/L LS decreased HCV RNA levels [core region (by 55% and 88%, respectively) and NS5A region (by 62% and 87%, respectively) after 24 h compared with vehicle (dimethyl sulphoxide) control (P < 0.01). Similarly HCV core and NS5A protein were decreased (by 85%, P < 0.01 and by 65%, P < 0.05, respectively) by LS 200 μmol/L. Bach1 and HMOX-1 RNA were also downregulated by LS treatment (P < 0.01), while Nrf2 protein was increased (P < 0.05).CONCLUSION: Our results demonstrate that treatment with LS downregulates HCV core and NS5A expression in CON1 cells which express full length HCV genotype 1b, and suggests that LS may prove to be a valuable alternative or adjunctive therapy for the treatment of HCV infection. | Marjan Mehrab-Mohseni Hossein Sendi Nury Steuerwald Sriparna Ghosh Laura W Schrum Herbert L Bonkovsky | 2011 | World Journal of Gastroenterology2011，17，13： | 3 |
| 2 | Association of abnormal morphology and altered gene expression in human preimplantation embryos显示文摘 | Wells D Bermudez MG Steuerwald N Malter HE Thornhill AR Cohen J | 2005 | Fertil Steril2005，84，： | 1 |
| 3 | Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis显示文摘 | Lakner AM Steuerwald NM Walling TL | | 0，，： | 1 |
| 4 | UPLC-MS/MS analysis of C5-acylcamitines in dried blood spots 显示文摘 | Janzen N Steuerwald U Sander S | 2013 | Clin ChimActa2013，421，： | 1 |
| 5 | Association of abnormal morphology and altered gene expression in human preimplantation embryos显示文摘 | Wells D Bermudez MG Steuerwald N | 2005 | Fertil Steril2005，84，2： | 1 |
| 6 | Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation developmene 显示文摘 | Wells D Bermudez MG Steuerwald N | 2005 | Hum Repred2005，20，5： | 1 |
| 7 | Nitric oxide synthase production and nitric oxide regulation of preimplantation embryo development 显示文摘 | TRANGUCH S STEUERWALD N HUET-HUDSON Y M | 2003 | Biol Reprod2003，68，5： | 1 |
| 8 | Prospective evaluation of right ventricular function and functional status 6 months after acute submassive pulmonary embolism:frequency of persistent or subsequent elevation in estimated pulmonary artery pressure显示文摘 | Kline JA Steuerwald MT Marchick MR | 2009 | Chest2009，136，5： | 1 |
| 9 | Analysis of gene expression in single oocytes and embryos by real-time rapid cycle fluorescence monitored RT-PCR显示文摘 | STEUERWALD N COHEN J HERRERA R J | 1999 | Mol Hum Reprod1999，5，11： | 1 |
| 10 | Nitric oxide synthase production and nitric oxide regulation of preimplantation embryo development显示文摘 | Tranguch S Steuerwald N Huet-Hudson YM | 2003 | Biol Reprod2003，68，： | 1 |
| 11 | The let-7 microR- NA enhances heine oxygenase-1 by suppressing Bachl and attenuates oxidant injury in human hepatocytes 显示文摘 | Hou W Tian Q Steuerwald NM | 2012 | Bio- chim Biophys Acta2012，1819，1112： | 1 |
| 12 | Analysis of gene expression in single oocytes and embryos by real-time rapid cycle fluorescence monitored RT-PCR显示文摘 | Steuerwald N Cohen J Herrera RJ | 1999 | Brenner CAMol Hum Reprod1999，5，11： | 1 |
| 13 | Coherent population transfer in NO with pulsed lasers: the consequences of hyperfine structure, Doppler broadening and dectromagnetically induced absorption 显示文摘 | KUHN A STEUERWALD S BERGMANN K | 1998 | European Physical Journal D1998，1，： | 1 |
| 14 | Maternal seafood diet, methylmercury exposure, and neonatal neurological function显示文摘 | STEUERWALD U WEIHE P JORGENSEN P J | 2000 | Journal of Pediatrics2000，136，： | 1 |
| 15 | Efficient Cell-free Production of Olfactory Receptors: Detergent Optimization, Structure, and Ligand Binding Analyses 显示文摘 | Liselotte Kaiser Johanna Graveland-Bikker Dirk Steuerwald etc | 2008 | PNAS2008，105，15： | 1 |
| 16 | Maternal seafood diet,methylmercury exposure,and neonatal nearo-logic function显示文摘 | Steuerwald U Weihe P Jorgensen PJ | 2000 | J Pediatr2000，136，5： | 1 |
| 17 | Coherent population transfer in NO with pulsed lasers: the consequences of hyperfine structure, Doppler broadening and electromagnetically induced absorption显示文摘 | KUHN A STEUERWALD S BERGMANN K | 1998 | Eur Phys J D1998，1，1： | 1 |
| 18 | Prospective evaluation of right ventricular function and functional status 6 months after acute submassive pulmonary embolism: frequency of persistent or subsequent elevation in estimated pulmonary artery pressure 显示文摘 | Kline JA Steuerwald MT Marchick MR | 2009 | Chest2009，136，5： | 1 |
| 19 | Nitric oxide synthase production and Nitric oxide regulation of preimplantation embryo development显示文摘 | Tranguch S Steuerwald N Huet-Hudson YM | 2003 | Biol Reprod2003，68，5： | 1 |
| 20 | Association between spindle assembly checkpoint expression and maternal age in human oocytes显示文摘 | Steuerwald N Cohen J Herrera RJ | 2001 | Mol Hum Reprod2001，7，1： | 1 |
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