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| 1 | Indoleamine 2,3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines显示文摘Indoleamine 2, 3-dioxygenase (IDO) is a rate-limiting enzyme for the tryptophan catabolism. In human and murine cells, IDO inhibits antigen-specific T cell proliferation in vitro and suppresses T cell responses to fetal alloantigens during murine pregnancy. In mice, IDO expression is an inducible feature of specific subsets of dendritic cells (DCs), and is important for T cell regulatory properties. However, the effect of IDO and tryptophan deprivation on DC func- tions remains unknown. We report here that when tryptophan utilization was prevented by a pharmacological inhibitor of IDO, 1-methyl tryptophan (1MT), DC activation induced by pathogenic stimulus lipopolysaccharide (LPS) or inflam- matory cytokine TNF-α was inhibited both phenotypically and functionally. Such an effect was less remarkable when DC was stimulated by a physiological stimulus, CD40 ligand. Tryptophan deprivation during DC activation also regu- lated the expression of CCR5 and CXCR4, as well as DC responsiveness to chemokines. These results suggest that tryptophan usage in the microenvironment is essential for DC maturation, and may also play a role in the regulation of DC migratory behaviors. | Shih Ling HWANG Nancy Pei-Yee CHUNG Jacqueline Kwai-Yi CHAN Chen-Lung Steve LIN | 2005 | Cell Research2005，15，3： | 11 |
| 2 | Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke显示文摘Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV. | Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung Steve O’Donnell J Scott McNally David Tirschwell Jennifer J Majersik | 2017 | Stroke & Vascular Neurology2017，2，1： | 6 |
| 3 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn’s and Colitis Epidemiology Study显示文摘 | Siew C. Ng Whitney Tang Jessica Y. Ching May Wong Chung Mo Chow A.J. Hui T.C. Wong Vincent K. Leung Steve W. Tsang Hon Ho Yu Mo Fong Li Ka Kei Ng Michael A. Kamm Corrie Studd Sally Bell Rupert Leong H. Janaka de Silva Anuradhani Kasturiratne M.N.F. Mufeen | 2013 | Gastroenterology2013，，1： | 6 |
| 4 | Face Recognition:A Convolutional Neural-Network Approach显示文摘 | Steve Lawrence Lee Giles C Ah Chung Tsoi | 1997 | IEEE Trans on Neural Networks1997，8，1： | 1 |
| 5 | 15-YEAR EXPERIENCE WITH THE MANAGEMENT OF EXTRINSIC URETERAL OBSTRUCTION WITH INDWELLING URETERAL STENTS显示文摘 | STEVE Y. CHUNG ROBERT J. STEIN DOUGLAS LANDSITTEL BENJAMIN J. DAVIES DAVID C. CUELLAR RONALD L. HREBINKO TATUM TARIN TIMOTHY D. AVERCH | 2004 | The Journal of Urology2004，，2： | 1 |
| 6 | Preparation and characterization of fluorine- containing poly- benziruidazole/imidazole hybrid membranes for proton exchange membrane fuel cells显示文摘 | Shih Wei Chuang Steve Lien Chung Hsu Ming Lun Yang | 2008 | European Polymer Journal2008，44，7： | 1 |
| 7 | Face Recognition: A Convolutional Neural-network Approach显示文摘 | Steve Lawrence Lee Giles C Ah Chung Tsoi | 1997 | IEEE Trans on Neural Networks1997，8，1： | 1 |
| 8 | Enhenced thermal con- ductivity of polyimide films via a hybrid of micro- and nano-sized boron nitride显示文摘 | Tung L L Steve L Chung H | 2010 | Journal of Physical Chem- istry B2010，114，20： | 1 |
| 9 | Face recognition: a convolution neural network approach显示文摘 | Steve Lawrence lee Giles C Ah Chung Tsoi Andrew D Back | 1997 | IEEE Transactions on Neural Networks1997，8，1： | 1 |
| 10 | Face recognition: a convolutional neural network approach 显示文摘 | Lawrence Steve Lee Giles C Chung Tsoi Ah | 1997 | IEEE Transactions on Neural Networks1997，8，1： | 1 |
| 11 | A new approach to modeling the substrate eurrent of pre-stressed and post-stressed MOSFET' s显示文摘 | Jiuun-Jer Yang Steve Shao-Shiun Chung Peng- Cheng Chou | 1995 | Electron Dev1995，42，6： | 1 |
| 12 | Thermoelectricity principle:the drying process of colded proceeding显示文摘 | LAWRENCE Steve LEE C Giles TSOI Ah Chung | 1997 | IEEE Trans1997，8，1： | 1 |
| 13 | Noisy time series prediction using recurrent neural networks and grammatical inference显示文摘 | LeeGiles C Steve Lawrence Ah Chung Tsoi | 2001 | Machine Learning2001，44，： | 1 |
| 14 | Comparative retention rates and long-term tolerability of new antiepileptic drugs显示文摘 | Steve Chung Norman Wang Nicole Hank | 2007 | Seizure: European Journal of Epilepsy2007，，4： | 1 |
| 15 | Face recognition:a convolution neural network approach显示文摘 | STEVE L GILES L C CHUNG T A | 1997 | IEEE Trans on Neural Networks1997，8，1： | 1 |
| 16 | 15-YEAR EXPERIENCE WITH THE MANAGEMENT OF EXTRINSIC URETERAL OBSTRUCTION WITH INDWELLING URETERAL STENTS显示文摘 | STEVE Y. CHUNG ROBERT J. STEIN DOUGLAS LANDSITTEL BENJAMIN J. DAVIES DAVID C. CUELLAR RONALD L. HREBINKO TATUM TARIN TIMOTHY D. AVERCH | 2004 | The Journal of Urology2004，，2： | 1 |
| 17 | Preparation of highly concentrated and stable suspensions of silver nanoparticles by an organic base catalyzed reduction reaction 显示文摘 | Rang - Tarng Wu Steve Lien - Chung Hsu | 2008 | Materials Research Bulletin2008，43，： | 1 |
| 18 | Comparative retention rates and long-term tolerability of new antiepileptic drugs显示文摘 | Steve Chung Norman Wang Nicole Hank | 2007 | Seizure2007，16，4： | 1 |
| 19 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn’s and Colitis Epidemiology Study显示文摘 | Siew C. Ng Whitney Tang Jessica Y. Ching May Wong Chung Mo Chow A.J. Hui T.C. Wong Vincent K. Leung Steve W. Tsang Hon Ho Yu Mo Fong Li Ka Kei Ng Michael A. Kamm Corrie Studd Sally Bell Rupert Leong H. Janaka de Silva Anuradhani Kasturiratne M.N.F. Mufeen | 2013 | Gastroenterology2013，，1： | 1 |
| 20 | Face recognition:a convolutional neural-network approach显示文摘 | Steve Lawrence Lee Giles C Ah Chung Tsoi | 1997 | IEEE Trans on Neural Networks1997，8，1： | 1 |
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