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| 1 | Genetic Heritability of Ischemic Stroke and the Contribution of Previously Reported Candidate Gene and Genomewide Associations显示文摘 | Steve Bevan Matthew Traylor Poneh Adib-Samii Rainer Malik Nicola L. M. Paul Caroline Jackson Martin Farrall Peter M. Rothwell Cathie Sudlow Martin Dichgans Hugh S. Markus | 2012 | Stroke2012，，12： | 1 |
| 2 | Elucidating the genetic basis of antioxidant status in lettuce (Lactuca sativa)显示文摘A diet rich in phytonutrients from fruit and vegetables has been acknowledged to afford protection against a range of human diseases,but many of the most popular vegetables are low in phytonutrients.Wild relatives of crops may contain allelic variation for genes determining the concentrations of these beneficial phytonutrients,and therefore understanding the genetic basis of this variation is important for breeding efforts to enhance nutritional quality.In this study,lettuce recombinant inbred lines,generated from a cross between wild and cultivated lettuce(Lactuca serriola and Lactuca sativa,respectively),were analysed for antioxidant(AO)potential and important phytonutrients including carotenoids,chlorophyll and phenolic compounds.When grown in two environments,96 quantitative trait loci(QTL)were identified for these nutritional traits:4 for AO potential,2 for carotenoid content,3 for total chlorophyll content and 87 for individual phenolic compounds(two per compound on average).Most often,the L.serriola alleles conferred an increase in total AOs and metabolites.Candidate genes underlying these QTL were identified by BLASTn searches;in several cases,these had functions suggesting involvement in phytonutrient biosynthetic pathways.Analysis of a QTL on linkage group 3,which accounted for>30%of the variation in AO potential,revealed several candidate genes encoding multiple MYB transcription factors which regulate flavonoid biosynthesis and flavanone 3-hydroxylase,an enzyme involved in the biosynthesis of the flavonoids quercetin and kaempferol,which are known to have powerful AO activity.Follow-up quantitative RT-PCR of these candidates revealed that 5 out of 10 genes investigated were significantly differentially expressed between the wild and cultivated parents,providing further evidence of their potential involvement in determining the contrasting phenotypes.These results offer exciting opportunities to improve the nutritional content and health benefits of lettuce through marker-assisted breeding. | Annabelle Damerum Stacey L Selmes Gaia F Biggi Graham JJ Clarkson Steve D Rothwell Maria JoséTruco Richard W Michelmore Robert D Hancock Connie Shellcock Mark A Chapman Gail Taylor | 2015 | Horticulture Research2015，2，1： | 0 |
| 3 | Diversity in global gene expression and morphology across a watercress (Nasturtium officinale R. Br.) germplasm collection: first steps to breeding显示文摘Watercress(Nasturtium officinale R.Br.)is a nutrient intense,leafy crop that is consumed raw or in soups across the globe,but for which,currently no genomic resources or breeding programme exists.Promising morphological,biochemical and functional genomic variation was identified for the first time in a newly established watercress germplasm collection,consisting of 48 watercress accessions sourced from contrasting global locations.Stem length,stem diameter and anti-oxidant(AO)potential varied across the accessions.This variation was used to identify three extreme contrasting accessions for further analysis.Variation in global gene expression was investigated using an Affymetrix Arabidopsis ATH1 microarray gene chip,using the commercial control(C),an accession selected for dwarf phenotype with a high AO potential(dwarfAO,called‘Boldrewood’)and one with high AO potential alone.A set of transcripts significantly differentially expressed between these three accessions,were identified,including transcripts involved in the regulation of growth and development and those involved in secondary metabolism.In particular,when differential gene expression was compared between C and dwarfAO,the dwarfAO was characterised by increased expression of genes encoding glucosinolates,which are known precursors of phenethyl isothiocyanate,linked to the anti-carcinogenic effects well-documented in watercress.This study provides the first analysis of natural variation across the watercress genome and has identified important underpinning information for future breeding for enhanced anti-carcinogenic properties and morphology traits in this nutrient-intense crop. | Adrienne C.Payne Graham J.J.Clarkson Steve Rothwell Gail Taylor | 2015 | Horticulture Research2015，2，1： | 0 |
| 4 | 阿斯顿·马丁推出微型车:每辆5万美元显示文摘阿斯顿·马丁(AstonMartin)是查尔斯王子(PrineeCharles)钟爱的跑车品牌,也是詹姆斯·邦德(JamesBond)的最爱,你大概想不到这样一个品牌会想要把车卖给那些找不到泊车位的人。然而,为了扩大客户层面,这家英国车厂本月推出了Cygnet都市微型车,希望车头上的阿斯顿·马丁徽标和车内大量的手工真皮装饰能说服买家拿出3.0995万英镑(5.05万美元)买下它来。 | 史蒂夫·罗斯维尔(Steve Rothwell) 曹亚非(译) | 2011 | 商业周刊(中文版)2011，，7： | 0 |
| 5 | 免受希思罗机场那般地狱之苦显示文摘距离市中心较远的机场纷纷兜售其客流不拥挤、更易搭乘的优势
“如果置身希思罗机场。你会心烦意乱、不知所措” | 史蒂夫·罗恩韦尔(Steve Rothwell) 赵克雨(译) | 2011 | 商业周刊(中文版)2011，，4： | 0 |
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