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| 1 | Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis显示文摘AIM:To analyze phospholipid profiles in intrahepatic bile from patients with primary sclerosing cholangitis(PSC)and secondary sclerosing cholangitis(SSC).METHODS:Intrahepatic bile specimens collected via endoscopic retrograde cholangiography from 41 patients were analyzed.Fourteen of these patients were diagnosed with PSC,10 with SSC,11 with choledocholithiasis or no identifiable biliary disease,and 6 with cholangiocellular carcinoma(CCC).Bile acid,cholesterol,protein,and bilirubin contents as well as pancreas lipase activity in bile were determined by biochemical methods.Phosphatidylcholine(PC)and lysophosphatidylcholine(LPC)species were quantified using nanoelectrospray ionization tandem mass spectrometry.RESULTS:Bile from all the examined patient groups showed a remarkably similar PC and LPC species composition,with only minor statistical differences.Total biliary PC concentrations were highest in controls(8030±1843 mol/L)and lowest in patients with CCC(1969±981 mol/L)(P=0.005,controls vs SSC and CCC,respectively,P<0.05).LPC contents in bile were overall low(4.2%±1.8%).Biliary LPC/PC ratios and ratios of biliary PC to bilirubin,PC to cholesterol,PC to protein,and PC to bile acids showed no intergroup differences.CONCLUSION:PC and LPC profiles being similar in patients with or without sclerosing cholangitis,these phospholipids are likely not of major pathogenetic importance in this disease group. | Annika Gauss Robert Ehehalt Wolf-Dieter Lehmann Gerhard Erben Karl-Heinz Weiss Yvonne Schaefer Petra Kloeters-Plachky Adolf Stiehl Wolfgang Stremmel Peter Sauer Daniel Nils Gotthardt | 2013 | World Journal of Gastroenterology2013，19，33： | 3 |
| 2 | Is stenting necessary after balloon dilation of post-transplantation biliary strictures? Results of a prospective comparative study显示文摘 | H. Kulaksiz K. Weiss D. Gotthardt G. Adler W. Stremmel A. Schaible A. Dogan A. Stiehl P. Sauer | 2008 | Endoscopy2008，，09： | 2 |
| 3 | Development of dominant bile duct stenoses in patients with primary sclerosing cholangitis treated with ursodeoxycholic acid:outcome after endoscopic treatment显示文摘 | Stiehl A Rudolph G Kloters-plachky P | | 0，，： | 2 |
| 4 | Bile salt sulphates in cholestasis显示文摘 | Stiehl A | 1974 | Eur J Clin Invest1974，4，1： | 1 |
| 5 | Hypoxia- inducible factor-1 ( HIF-1 ) : a novel transcription factor inimmune reactions 显示文摘 | Hellwig B T Stiehl D P Wagner A E | 2005 | J Interferon Cytokine Res2005，25，6： | 1 |
| 6 | Hypoxia - inducible factor - 1 ( HIF - 1 ) : a novel transcription factor inimmune reactions 显示文摘 | Hellwig - Burgel T Stiehl DP Wagner AE | 2005 | J Interferon Cytokine Res2005，25，6： | 1 |
| 7 | Expansion of adipose mesenchymal stromal cells is affected by human platelet lysate and plating density显示文摘 | Cholewa D Stiehl T Schellenberg A | 2011 | Cell Transplant2011，20，9： | 1 |
| 8 | Kinematics of the patellofemoral joint in total knee arthroplasty显示文摘 | Stiehl J B Komistek R D Dennis D A | 2001 | Journal of Arthroplasty2001，16，6： | 1 |
| 9 | Identification of the causes of intrauterine death during 310 consecutive autopsies显示文摘 | Horn LC Langner A Stiehl P | | 0，，02： | 1 |
| 10 | Endoscopic Retrograde Cholangiopancreatography in Diagnosis and Treatment of Primary Sclerosing Cholangitis显示文摘 | Daniel Gotthardt Adolf Stiehl | 2010 | Clinics in Liver Disease2010，，2： | 1 |
| 11 | Mathematical Model of the Lower Extremity Joint Reaction Forces Using Kane's Method of Dynamics 显示文摘 | Komistek RD Stiehl JB Dennis DA | 1998 | Journal of Biomechanics Transactions of the ASME (S0148-0731)1998，31，2： | 1 |
| 12 | Shift in Thl (IL-2 and IFN- gamma) and Th2 (IL-10 and IL-4) cytokine mRNA balance within two new histological main-types of rheumatoid-arthritis (RA) 显示文摘 | Ruschpler P Stiehl P | 2002 | Cell Mol Biol (Noisyle-grand)2002，48，3： | 1 |
| 13 | Normoxic induction of the hypoxia inducible factor 1 alpha by insulin and interleukin-1 beta involves the phosphatedylino-sitol 3-kinase pathway 显示文摘 | Stiehl DP Jelkmann W Wenger RH | 2002 | FEBS Lett2002，512，13： | 1 |
| 14 | HIF prolyl-4-hydroxylase interacting proteins:consequences for drug targeting显示文摘 | Wenger R H Camenisch G Stiehl D P | 2009 | Curr Pharm Des2009，15，33： | 1 |
| 15 | Mechanism of hepato-protective action of bile salts in liver disease显示文摘 | STIEHL A BENZ C SAUER P | 1999 | Gas-troenterol Clin North Am1999，28，1： | 1 |
| 16 | Interaction of HIF and USF signaling pathways in human genes flanked hy hypoxia-response elements and E-box palindromes 显示文摘 | J Hu J Stiehl DP Setzer C | 2011 | Mol Cancer Res2011，9，11： | 1 |
| 17 | Landmark-based elastic registration using approximating thin-plate splines显示文摘 | Rohr K Stiehl H Sprengel R | 2001 | IEEE Trans Med Imag2001，20，： | 1 |
| 18 | Genes downstream from pucB and pucA are essential for formation of the B800-850 complex of Rhodobacter capsulatus 显示文摘 | Tichy HV Oberlé B Stiehle H Schiltz E Drews G | 1989 | J Bacteriol1989，171，： | 1 |
| 19 | Acute pasteurella multocida in total knee arthroplasty显示文摘 | James B Stiehl Lawrence A Sterkin Charles F Brummitt | 2004 | The Journal of Arthroplasty2004，，2： | 1 |
| 20 | Shift in Thl (IL2 and IFN-gamma) and Th2 (IL-10 and IL-4) cytokine mRNA balance within two new histological main-types of rheumatoid-arthritis (RA)显示文摘 | Rusehpler P Stiehl P | 2002 | Cel- lular and Molecular Biology2002，48，3： | 1 |
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