|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation and comparison of short chain fatty acids composition in gut diseases显示文摘BACKGROUND An altered (dysbiosis) and unhealthy status of the gut microbiota is usually responsible for a reduction of short chain fatty acids (SCFAs) concentration. SCFAs obtained from the carbohydrate fermentation processes are crucial in maintaining gut homeostasis and their determination in stool samples could provide a faster, reliable and cheaper method to highlight the presence of an intestinal dysbiosis and a biomarker for various gut diseases. We hypothesize that different intestinal diseases, such as celiac disease (CD), adenomatous polyposis (AP) and colorectal cancer (CRC) could display a particular fecal SCFAs’ signature. AIM To compare the fecal SCFAs’ profiles of CD, AP, CRC patients and healthy controls, using the same analytical method. METHODS In this cross-sectional study, we defined and compared the SCFAs’ concentration in fecal samples of 9 AP, 16 CD, 19 CRC patients and 16 healthy controls (HC). The SCFAs’ analysis were performed using a gas-chromatography coupled with mass spectrometry method. Data analysis was carried out using Wilcoxon ranksum test to assess pairwise differences of SCFAs’ profiles, partial least squaresdiscriminate analysis (PLS-DA) to determine the status membership based on distinct SCFAs’ profiles, and Dirichlet regression to determine factors influencing concentration levels of SCFAs. RESULTS We have not observed any difference in the SCFAs’ amount and composition between CD and healthy control. On the contrary, the total amount of SCFAs was significantly lower in CRC patients compared to HC (P = 0.044) and CD (P = 0.005). Moreover, the SCFAs’ percentage composition was different in CRC and AP compared to HC. In detail, HC displayed higher percentage of acetic acid (P value = 1.3 × 10-6) and a lower amount of butyric (P value = 0.02192), isobutyric (P value = 7.4 × 10-5), isovaleric (P value = 0.00012) and valeric (P value = 0.00014) acids compared to CRC patients. AP showed a lower abundance of acetic acid (P value = 0.00062) and higher percentages of propionic (P value = 0.00433) and isovaleric (P value = 0.00433) acids compared to HC. Moreover, AP showed higher levels of propionic acid (P value = 0.03251) and a lower level of isobutyric acid (P value = 0.00427) in comparison to CRC. The PLS-DA model demonstrated a significant separation of CRC and AP groups from HC, although some degree of overlap was observed between CRC and AP. CONCLUSION Analysis of fecal SCFAs shows the potential to provide a non-invasive means of diagnosis to detect patients with CRC and AP, while CD patients cannot be discriminated from healthy subjects. | Elena Niccolai Simone Baldi Federica Ricci Edda Russo Giulia Nannini Marta Menicatti Giovanni Poli Antonio Taddei Gianluca Bartolucci Antonino Salvatore Calabrò Francesco Claudio Stingo Amedeo Amedei | 2019 | World Journal of Gastroenterology2019，25，36： | 4 |
| 2 | Cloning and characterization of a repetitive DNA detected by Hind Ⅲ in the genome of Raja montagui (Batoidea,Chondrichthyes)显示文摘 | Rocco L Stingo V Bellitti M | 1996 | Gene1996，176，： | 1 |
| 3 | (TTAGGG) n telomeric sequence in selachian chromosomes显示文摘 | Rocco L Costagliola D Stingo V | 2001 | Heredity2001，87，5： | 1 |
| 4 | Trends of karyological evolution in pelobatoid frogs显示文摘 | Morescalchi A Olmo E Stingo V | 1977 | Experientia1977，33，： | 1 |
| 5 | Toward optimizing patient-specific IMRT QA techniques in the accurate detection of dosimetrically acceptable and unacceptable patient plans显示文摘 | McEenzie EM Balter PA Stingo FC | 2014 | Med Phys2014，41，12： | 1 |
| 6 | Selachian cytogenetics : a review 显示文摘 | Stingo V Rocco L | 2001 | Genetica2001，111，： | 1 |
| 7 | Chondrichthyan cytogenetics : a comparison with Teleosteans 显示文摘 | Stingo V Rocco L | 1991 | J Mol Evol1991，33，： | 1 |
| 8 | Presence of C -type natri 2uretic peptides in cultured human endothelial cells and plasma显示文摘 | STINGO A J CLAVELL A L HEUBLEIN D M | 1992 | Am JPhysiol1992，235，： | 1 |
| 9 | Presence of C-type natriuretic peptide in cultured human endothelial cells and plasma 显示文摘 | Clavell AL Heublein DM | 1992 | Am JPhysiol1992，235，： | 1 |
| 10 | High quality machinerobust image features: Identification in nonsmall cell lung cancer computed tomography images显示文摘 | Hunter LA Krafft S Stingo F | 2013 | Med Phys2013，40，12： | 1 |
| 11 | Cardiovascular and renal action of C-type natriuretic peptide显示文摘 | Stingo A J Clavell L Aarhus L L | 1992 | Am J Physiol1992，262，12： | 1 |
| 12 | C-type natriuretic peptide:a selective cardiovascular peptide 显示文摘 | Clavell AL Stingo A J Wei CM | 1993 | Am J Physiel1993，264，： | 1 |
| 13 | Cardiovascular and renal actions of C-type natriuretic peptide 显示文摘 | STINGO A J CLAVELL A L AARHUS L L | 1992 | Am J Physiol1992，262，12： | 1 |
| 14 | Presence of C-type na- triuretic pcptide in cultured human endothelial ceils and plasma显示文摘 | Stingo AJ Clavell AL Heublein DM | 1992 | Am J Physiol1992，263，4： | 1 |
| 15 | Institutional Patient-Specific Intensity Modulated Radiation Therapy Quality Assurance Does Not Predict Unacceptable Plan Delivery as Measured by Imaging and Radiation Oncology Core at Houston’s Head and Neck Phantom显示文摘 | Stephen F. Kry Andrea Molineu James Kerns Austin Faught Jessie Y. Huang Kiley Pulliam Jackie Tonigan Paola Alvarez Francesco Stingo David S. Followill | 2014 | International Journal of Radiation Oncology, Biology, Physics2014，，： | 1 |
| 16 | Cariologia di due torpedini italiane显示文摘 | Stingo V | 1976 | Boll Zool1976，43，： | 1 |
| 17 | 2',3'-Cyclic nucleotide 3'-phosphodiesterase:a membrane-bound,microtubule-associated protein and membrane anchor for tubulin显示文摘 | Bifulco M Laezza C Stingo S | | 0，，： | 1 |
| 18 | Sequence organization in the DNA of three selachians显示文摘 | Olmo E Stingo V Odierna G | 1982 | Experientia1982，38，： | 1 |
| 19 | Repetitive DNA and polyploidy in selachians显示文摘 | Olmo E Stingo V Cobror O | 1982 | Comp Biochem Physiol B1982，73，4： | 1 |
| 20 | Genome size and A-T rich DNA in selachians显示文摘 | Stingo V Capriglione T Rocco L | 1989 | Genetica1989，79，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员