| 11 | 原发性高血压患者左心室向心性重构与C-反应蛋白和血清淀粉样蛋白A水平之间的关系显示文摘In this study, we investigated possible relations between left ventricular(LV) concentric remodeling and plasma levels of high-sensitivity C-reactive protein(hs-CRP) and serum amyloid-A(SAA) in subjects who had essential hypertension; 65 consecutive subjects who had hypertension, did not have diabetes, and had normal LV mass were categorized as those whose LV relative wall thickness was< 0.44(n=41) and those whose relative wall thickness was ≥0.44. Venous blood samples were collected for determination of metabolic profile and plasma levels of hs-CRP and SAA. Subjects whose relative LV wall thickness was ≥0.44 compared with those whose relative LV wall thickness was< 0.44 had significantly increased systolic blood pressure by 4.5 mm Hg(p=0.015) and higher levels of plasma hs-CRP(1.80 vs 1.39mg/L, p=0.001) and SAA(10.22 vs 4.86 mg/dl, p=0.000), although the 2 groups did not differ with regard to age, gender, waist-to-hip ratio, and diastolic blood pressure(p=NS for all). In the entire study population, log hs-CRP and SAA exhibited positive relations with systolic blood pressure(r=0.21 and r=0.29, respectively; p< 0.05 for the 2 markers) and relative wall thickness(r=0.26 and r=0.81, respectively; p< 0.05 for the 2 markers). Multiple linear regression analysis showed that age, gender, and diastolic blood pressure were significantly associated with LV mass index(p< 0.05), whereas gender, body mass index, log hs-CRP, and SAA were significantly associated with relative wall thickness (p< 0.003). By analysis of covariance, log hs-CRP and SAA were significantly different between subjects whose relative LV wall thickness was ≥0.44 and those whose relative LV wall thickness was< 0.44 after the adjustment for age, gender, body mass index, and systolic/diastolic blood pressure(p< 0.005 for the 2 markers). In conclusion, alterations in LV geometry are associated with increased serum CRP and SAA levels in patients who are newly diagnosed with essential hypertension. | Tsioufis C. Stougiannos P. Kakkavas A. 王亭忠 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，1： | 0 |
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