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| 1 | Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity and Protect Against Lethal Systemic Infection显示文摘Staphylococcus aureus(S.aureus)is a leading human pathogen capable of producing severe invasive infections such as bacteremia,sepsis,and endocarditis with high morbidity and mortality,exacerbated by the increasingly widespread antibiotic resistance exemplified by methicillin-resistant strains(MRSA).S.aureus pathogenesis is fueled by the secretion of toxins—such as the membrane-damaging pore-forming atoxin,which have diverse cellular targets including the epithelium,endothelium,leukocytes,and platelets.Here,we examine the use of human platelet membrane-coated nanoparticles(PNPs)as a biomimetic decoy strategy to neutralize S.aureus toxins and preserve host cell defense functions.The PNPs blocked platelet damage induced by S.aureus secreted toxins,thereby supporting platelet activation and bactericidal activity.Likewise,the PNPs blocked macrophage damage induced by S.aureus secreted toxins,thus supporting macrophage oxidative burst,nitric oxide production,and bactericidal activity,and diminishing MRSA-induced neutrophil extracellular trap release.In a mouse model of MRSA systemic infection,PNP administration reduced bacterial counts in the blood and protected against mortality.Taken together,the results from the present work provide a proof of principle of the therapeutic benefit of PNPs in toxin neutralization,cytoprotection,and increased host resistance to invasive S.aureus infection. | Jwa-Kyung Kim Satoshi Uchiyama Hua Gong Alexandra Stream Liangfang Zhang Victor Nizet | 2021 | Engineering2021，7，8： | 2 |
| 2 | Urban Stream Restoration显示文摘 | ASCE River Restoration Sub-committee on Urban Stream Res-toration | | 0，，07： | 1 |
| 3 | STREAM:the stanford stream data manager显示文摘 | The Stream Group | 2003 | IEEE Data Engineering Bulletin2003，26，1： | 1 |
| 4 | Concepts and methods for assessing solute dynamics in stream ecosystems 显示文摘 | Stream Solute Workshop | 1990 | Journal of the North American Benthological Society1990，9，2： | 1 |
| 5 | Supression of tumor growth through disruption of hypoxia-inducible transcription显示文摘 | Andrew LK Stream W Jeffery M | 2000 | Nature Med2000，67，12： | 1 |
| 6 | Local anesthetic injection deep to the fascia iliaca at the level of the inguinal ligament:the pattern of distribution and effects on the obturator nerve 显示文摘 | SWENSON JD DAVIS JJ STREAM JO | 2015 | J Clin Anesth2015，27，8： | 1 |
| 7 | STREAM:the stanford stream data manager显示文摘 | The STREAM Group | 2003 | IEEE Data Engineering Bulletin2003，26，1： | 1 |
| 8 | Urban stream restoration 显示文摘 | ASCE River Restoration Subcommittee on Urban Stream Restora- tion | 2003 | Journal of Hydraulic Engineer- ingASCE2003，，7： | 1 |
| 9 | Percutancous endopyelotomy显示文摘 | Stream SB | 2000 | Urol Clin North Am2000，27，4： | 1 |
| 10 | Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment 显示文摘 | Stream J'O Grissom CK | 2008 | Wilderness Environ Med2008，19，4： | 1 |
| 11 | X-ray scattering from interfacial roughness in multiplayer structures 显示文摘 | | 1992 | J Appl Phys1992，71，： | 1 |
| 12 | Adipose - derived cells 显示文摘 | Mehga E Stream BM Duckers H J | 2007 | Cell Transplant2007，16，9： | 1 |
| 13 | Stream:the Stanford stream data manager显示文摘 | The STREAM Group | 2003 | IEEE Data Engineering Bulletin2003，26，1： | 1 |
| 14 | 2003, Urban stream restoration 显示文摘 | ASCE River Restoration Subcommittee on Urban Stream Restoration | 2003 | Journal of Hydraulic Engineering ASCE2003，129，7： | 1 |
| 15 | phase of a refinery naphtha zeolite catalysts显示文摘 | Antonia Fflnez Antonio De Hydroisomerization in liquid stream over Pt - Ni/H-beta Lucas Paula Sdnchez | 2008 | Chemical Engineering Journal2008，136，23： | 1 |
| 16 | Concepts and methods for assessing solute dynamics in stream ecosystems显示文摘 | Stream Solute Workshop | 1990 | J N Am Benthol Soc1990，9，： | 1 |
| 17 | Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome 显示文摘 | Garred P Stream J J Quist L | 2003 | J Infect Dis2003，188，9： | 1 |
| 18 | Methanotrophic symbiont location and fate of carbon incorporated from methane in a hydrocarbon seep mussel 显示文摘 | STREAMS M E FISHER C R FIALA-MEDIONI | 1997 | Mar Biol1997，129，： | 1 |
| 19 | Clinical and pathologic features of nephrogenic fibrosing dermopathy:a report of two cases显示文摘 | Streams B N Liu V Liegeois N | 2003 | J Am Acad Dermatol2003，48，： | 1 |
| 20 | STREAM:The Stanford stream data manager显示文摘 | The STREAM Group | 2003 | IEEE Data Engineering Bulletin2003，26，1： | 1 |
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