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| 1 | Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender显示文摘AIM: To investigate age-and gender-related differences in non-culprit versus culprit coronary vessels assessed with virtual histology intravascular ultrasound (VH-IVUS). METHODS: In 390 patients referred for coronary angiography to a single center (Luzerner Kantonsspital, Switzerland) between May 2007 and January 2011, 691 proximal vessel segments in left anterior descending, circumflex and/or right coronary arteries were imaged by VH-IVUS. Plaque burden and plaque composition(fibrous, fibro-fatty, necrotic core and dense calcium volumes) were analyzed in 3 age tertiles, according to gender and separated for vessels containing non-culprit or culprit lesions. To classify as vessel containing a culprit lesion, the patient had to present with an acute coronary syndrome, and the VH-IVUS had to be performed in a vessel segment containing the culprit lesion according to conventional coronary angiography. RESULTS: In non-culprit vessels the plaque burden increased significantly with aging (in men from 37% ± 12% in the lowest to 46% ± 10% in the highest age tertile, P < 0.001; in women from 30% ± 9% to 40% ± 11%, P < 0.001); men had higher plaque burden than women at any age (P < 0.001 for each of the 3 age tertiles). In culprit vessels of the lowest age tertile, plaque burden was significantly higher than that in non- culprit vessels (in men 48% ± 6%, P < 0.001 as compared to non-culprit vessels; in women 44% ± 18%, P = 0.004 as compared to non-culprit vessels). Plaque burden of culprit vessels did not significantly change during aging (plaque burden in men of the highest age tertile 51% ± 9%, P = 0.523 as compared to lowest age tertile; in women of the highest age tertile 49% ± 8%, P = 0.449 as compared to lowest age tertile). In men, plaque morphology of culprit vessels became increasingly rupture-prone during aging (increasing percentages of necrotic core and dense calcium), whereas plaque morphology in non-culprit vessels was less rupture-prone and remained constant during aging. In women, necrotic core in non-culprit vessels was very low at young age, but increased during aging resulting in a plaque morphology that was very similar to men. Plaque morphology in culprit vessels of young women and men was similar. CONCLUSION: This study provides evidence that age-and gender-related differences in plaque burden and plaque composition significantly depend on whether the vessel contained a non-culprit or culprit lesion. | Andreas W Schoenenberger Nadja Urbanek Stefan Toggweiler Andreas E Stuck Thérèse J Resink Paul Erne | 2013 | World Journal of Cardiology2013，5，3： | 7 |
| 2 | Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin Ⅱ are prevented by AMP-activated protein kinase 显示文摘 | Stuck B J Lenski M Bfhm M | 2008 | J Biol Chem2008，283，32： | 1 |
| 3 | Volumetric tissre reduction in radiofrequeney Surgery of the tongue 显示文摘 | Stuck B A Kopke J Hormann K | 2005 | Otolaryngol head neck surg2005，123，： | 1 |
| 4 | Farm-level studies of particulate phosphorus transport in the Everglades Agricultural Area 显示文摘 | STUCK J D LZUNO E T CAMPBELL K L | 2001 | Transactions of the American Society of Agncultural Engineers2001，44，： | 1 |
| 5 | Comparison of popula- tion genetic diversity between a rare, narrowly distributed species and a common, widespread species of Alnu ( Betu- laeeae) 显示文摘 | Gibson J P Rice S A Stucke C M | 2008 | Am J Bot2008，95，： | 1 |
| 6 | Comparison of popula- tion genetic diversity between a rare, narrowly distributed species and a common,widespread species of Alnus (Betu- laceae) 显示文摘 | Gibson J P Rice S A Stucke C M | 2008 | Am J Bot2008，95，： | 1 |
| 7 | Fleroxacin clinical pharmacokinetics显示文摘 | Stuck A E Kim D K Frey F J | 1992 | Clin Pharmacokinet1992，22，： | 1 |
| 8 | On the use of schematic eye models to estimate retinal image quality显示文摘 | LI G ZWICK H STUCK B LUND D J | 2000 | Journal of Biomedical Optics2000，5，3： | 1 |
| 9 | Volumetric tissue reduction in radiofrcquency surgery of the tongue base 显示文摘 | Stuck BA Kopke J Hormann If | 2005 | Otolaryngology Head and Neck Surgery2005，132，1： | 1 |
| 10 | A method forsimulation stable random显示文摘 | Chambers J M Mallows C L and Stuck B W | 1976 | Variables Journal of AmericanStatistical Association1976，71，5： | 1 |
| 11 | Retinal injury thresholds for blue wavelength lasers 显示文摘 | Lund D J Stuck BE Edsall P | 2006 | Health Phys2006，90，5： | 1 |
| 12 | Rheumatoid ar-thritis measures 显示文摘 | Fransen J Stuck G van Riel PL | 2003 | Arthritis Rheum2003，49，5： | 1 |
| 13 | Sediment inventory and phosphorus fractions for water conservation area canals in the Everglades显示文摘 | DIAZ O A DAROUB S H STUCK J D | 2006 | Soil Sci Soc Am J2006，70，： | 1 |
| 14 | Volum etric tissue reduction inradio frequency surgery of the tongue base显示文摘 | Stuck BA Kopke J Homan K | 2005 | Olaryngol Head Neck Surg2005，132，1： | 1 |
| 15 | Prehospital noninvasive pressure support ventilation for acute cardiogenic pulmonary edema显示文摘 | Weitz G Stuck J Zonak A | 2007 | Eur J Emerg Med2007，14，5： | 1 |
| 16 | Vol-um etric tissue reduction inrad io frequencysurgery of the tongue base显示文摘 | Stuck BA Kopke J Horman K | 2005 | OlaryngolHead Neck Surg2005，132，1： | 1 |
| 17 | Volum etric tissue reduction inradio frequency surgery o{ the tongue base 显示文摘 | Stuck BA Kopke J Homan K | 2005 | Olaryngol Head Neck Surg2005，132，1： | 1 |
| 18 | A meth- od for simulating stable random variables显示文摘 | Chambers J M Mallows C L Stuck B W | 1976 | Jour- nal of the American Statistical Association1976，71，354： | 1 |
| 19 | Risk factors for functional status decline in community-living elderly people: a systematic literature review 显示文摘 | STUCK A E WALTHERT J M NIKOLAUS T | 1999 | Soc Science Med1999，48，4： | 1 |
| 20 | A method for simulation stable random variables显示文摘 | CHAMBERS J M MALLOWS C L STUCK B M | 1976 | Journal of the American Statistical Association1976，71，6： | 1 |
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