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| 1 | Outline of the Report on Cardiovascular Disease in China,2010显示文摘Major and profound changes have taken place in China over the past 30 years.Rapid socioeconomic progress has exerted a great impact on lifestyle,ranging from food,clothing,working and living conditions,and means of transportation to leisure activities and entertainment.At the same time,new health problems have emerged,and health services are facing new challenges.Presently,cardiovascular diseases (CVD) are among the top health problems of the Chinese people,and pose a serious challenge to all engaged in the prevention and control of these diseases.An epidemic of CVD in China is emerging as a result of lifestyle changes,urbanization and longevity.Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures.Since 2005,guided by the Bureau of Disease Prevention of the Ministry of Health of the People's Republic of China and the National Center for Cardiovascular Diseases of China,nationwide experts in the fields of epidemiology,clinical medicine and health economics in the realms of CVD,cerebrovascular disease,diabetes and chronic kidney disease,completed the Report on Cardiovascular Diseases in China every year.The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD.In addition,as the report is authoritative,representative and readable,it will become an information platform in the CVD field and an important reference book for government,academic institutes,medical organizations and clinical physicians.This publication is expected to play a positive role in the prevention and control of CVD in China.We present an abstract from the Report on Cardiovascular Diseases in China (2010),including trends in CVD,morbidity and mortality of major CVDs,up-to-date assessment of risk factors,as well as health resources for CVD,and a profile of medical expenditure,with the aim of providing evidence for decision-making in CVD prevention and control programs in China,and of delivering the most authoritative information on CVD prevention and control for all citizens. | HUSheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Wen WANG Yong Jun WU Zhao Su CHEN Wei Wei LIU Ming Bo For the editorial board | 2012 | Biomedical and Environmental Sciences2012，25，3： | 93 |
| 2 | Modeling study of regional severe hazes over mid-eastern China in January 2013 and its implications on pollution prevention and control显示文摘The Nested Air Quality Prediction Model System(NAQPMS)was used to investigate the temporal and spatial variations of PM2.5over tropospheric central eastern China in January 2013.The impact of regional transport and its implications on pollution prevention and control were also examined.Comparison between simulated and observed PM2.5showed NAQPMS was able to reproduce the evolution of PM2.5during heavy haze episodes.The results indicated that regional transport of PM2.5played an important role in regional haze episodes in the city cluster including Hebei,Beijing and Tianjin(HBT).The cross-city clusters transport outside HBT and transport among cities inside HBT contributed 20%–35%and 26%–35%of PM2.5as compared with local emission,in HBT respectively.To meet the Air Quality Standards for Grade II,90%,90%and65%of emissions would have to be cut down in Hebei,Tianjin and Beijing,if non-control strategy was taken in the surrounding city clusters of HBT.This implicated that control of emissions in one city cluster is not sufficient to reduce regional haze events,and joint efforts among city clusters are essential.Besides regional transports,two-way feedback between boundary-layer evolution and PM2.5also significantly contributed to the formation of heavy hazes,which contributed 30%of monthly average PM2.5concentration in HBT. | WANG ZiFa LI Jie WANG Zhe YANG WenYi TANG Xiao GE BaoZhu YAN PinZhong ZHU LiLi CHEN XueShun CHEN HuanSheng WAND Wei LI JianJun LIU Bing WANG XiaoYan WAND Wei ZHAO YiLin LU Ning SU DeBin | 2014 | Science China Earth Sciences2014，57，1： | 106 |
| 3 | Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease显示文摘The etiopathology of inflammatory bowel disease(IBD)remains elusive.Accumulating evidence suggests that the abnormality of innate and adaptive immunity responses plays an important role in intestinal inflammation.IBD including Crohn's disease(CD)and ulcerative colitis(UC)is a chronic inflammatory disease of the gastrointestinal tract,which is implicated in an inappropriate and overactive mucosal immune response to luminalflora.Traditionally,CD is regarded as a Th1-mediated inflammatory disorder while UC is regarded as a Th2-like disease.Recently,Th17 cells were identif ied as a new subset of T helper cells unrelated to Th1 or Th2 cells,and several cytokines [e.g.interleukin(IL)-21,IL-23] are involved in regulating their activation and differentiation.They not only play an important role in host defense against extracellular pathogens,but are also associated with the development of autoimmunity and inflammatory response such as IBD.The identif ication of Th17 cells helps us to explain some of the anomalies seen in the Th1/Th2 axis and has broadened our understanding of the immunopathological effects of Th17 cells in the development of IBD. | Zhan-Ju Liu Praveen K Yadav Jing-Ling Su Jun-Shan Wang Ke Fei | 2009 | World Journal of Gastroenterology2009，15，46： | 44 |
| 4 | PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13显示文摘脉管的光滑的肌肉房间(VSMC ) 被将生物的活组织移植于培养基中培养方法从男 SpragueDawley 老鼠的胸的主动脉准备经由 3 kinase (PI3K )/Akt 发信号 transduction 小径由 apelin-13 导致了的 phosphoinositide 观察 VSMC 增长。PI3K, phospho-PI3K, phospho-Akt, ERK1/2, phospho-ERK1/2 和 cyclin D1 的表示被西方的污点分析检测。结果证明 apelin-13 在剂量依赖者和时间依赖者举止支持了 phospho-PI3K 和 phospho-Akt 的表示。PI3K 禁止者 LY294002 显著地减少了 phospho-PI3K, phospho-Akt, phospho-ERK1/2,和 cyclin D1 的表示由 apelin-13 导致了。Akt 禁止者 1701-1 显著地减少了 phospho-Akt, phospho-ERK1/2,和 cyclin D1 的表示由 apelin-13 刺激了。MTT 试金结果证明 PI3K 禁止者 LY294002 和 Akt 禁止者 1701-1 显著地禁止了 apelin-13 导致的 VSMC 增长。Apelin-13 通过表明 transduction 小径的 PI3K/Akt 支持了 VSMC 增长。 | Changhui Liu Tao Su Fang Li Lanfang Li Xuping Qin Weinan Pan Fen Feng Feng Chen Duanfang Liao Linxi Chen | 2010 | Acta Biochimica et Biophysica Sinica2010，42，6： | 41 |
| 5 | Effect of Heat Treatment on Microstructure and Property of Cr13 Super Martensitic Stainless Steel显示文摘The microstructures and mechanical properties of Cr13 super martensitic stainless steel after different heat treatments were studied. The results show that the structures of the steel after quenching are of lath martensite mixed with a small amount of retained austenite. With the raising quenching temperature, the original austenite grain size increases and the lath martensite gradually becomes thicker. The structures of the tempered steel are mixtures of tempered martensite and reversed austenite dispersed in the martensite matrix. The amount of reversed austenite is from 7.54% to 22.49%. After different heat treatments, the tensile strength, the elongation and the HRC hardness of the steel are in the range of 813-1 070 MPa, 10.1%-21.2% and 21.33-32.37, respectively. The steel displays the best comprehensive mechanical properties after the sample is quenched at 1 050 ℃ followed by tempering at 650 ℃. | LIU Yu-rong YE Dong YONG Qi-long SU Jie ZHAO Kun-yu JIANG Wen | 2011 | Journal of Iron and Steel Research(International)2011，18，11： | 49 |
| 6 | Non-antibiotic feed additives in diets for pigs:A review显示文摘A number of feed additives are marketed to assist in boosting the pigs' immune system, regulate gut microbiota, and reduce negative impacts of weaning and other environmental challenges.The most commonly used feed additives include acidifiers, zinc and copper, prebiotics, direct-fed microbials, yeast products, nucleotides, and plant extracts.Inclusion of pharmacological levels of zinc and copper, certain acidifiers, and several plant extracts have been reported to result in improved pig performance or improved immune function of pigs.It is also possible that use of prebiotics, direct-fed microbials, yeast,and nucleotides may have positive impacts on pig performance, but results have been less consistent and there is a need for more research in this area. | Yanhong Liu Charmaine D.Espinosa Jerubella J.Abelilla Gloria A.Casas L.Vanessa Lagos Su A.Lee Woong B.Kwon John K.Mathai Diego M.D.L.Navarro Neil W.Jaworski Hans H.Stein | 2018 | Animal Nutrition2018，，2： | 41 |
| 7 | The roles of macrophage autophagy in atherosclerosis显示文摘尽管药和治疗的各种各样的类型是可得到的对待动脉粥样硬化,它在全世界仍然是死亡的一个主要原因。巨噬细胞是泡沫房间的主要来源,它是动脉粥样硬化患者损害的特点。因而,在动脉粥样硬化的 pathophysiology 的巨噬细胞的角色逐渐地被调查。Autophagy 是一条自我保护的细胞的分解代谢的小径。自从它的发现, autophagy 被发现了与许多疾病被联系,包括心血管的疾病,恶意的肿瘤, neurodegenerative 疾病,和免疫系统混乱。积累的证据证明 autophagy 在禁止发炎和 apoptosis,并且在支持 efferocytosis 和胆固醇流出起一个重要作用。这些事实建议 autophagy 的正式就职可以为动脉粥样硬化的治疗作为潜在的策略被利用。在这评论,我们主要讨论在巨噬细胞之间的关系 autophagy 和动脉粥样硬化和分子的机制,以及在指向 autophagy 的过程到对待的最近的进展动脉粥样硬化。 | Bo-zong SHAO Bin-ze HAN Yan-xia ZENG Ding-feng SU Chong LIU | 2016 | Acta Pharmacologica Sinica2016，37，2： | 48 |
| 8 | The Sequence of Magmatic-Tectonic Events and Orogenic Processes of the Yanshan Belt, North China显示文摘This paper emphasizes that the interactive constraints of geology and isotopic dating is the best approach to construct the geological event sequence, and has compiled 106 data of reasonable isotopic ages for the igneous rocks of the Yanshan belt. We propose a sequence of mgmatic-tectonic events in the Jurassic-Cretaceous Yanshan orogen of North China. Five orogenic episodes are divided, (1) pre-and initial orogenic episode (Early Jurassic); (2) early orogenic episode (Middle Jurassic); (3) peak orogenic episode (Late Jurassic); (4) late orogenic episode (early Early Cretaceous),and (5) post-orogenic episode. Each episode is a short cycle, all of the orogenic processes construct a longer cycle, and they, in general, followed a counter-clockwise (ccw) PTt path. Finally, it is suggested that the Yanshanian movement was so intensive that the magmatism and tectonic deformation had involved all the lithosphere thickness and the lateAchaean-formed cratonic lithosphere had been significantly reworked. | DENG Jinfu, SU Shangguo, MO Xuanxue, ZHAO Guochun, XIAO Qinghiu, JI Guangyi,QIU Ruizhao, ZHAO Hailing, LUO Zhaohua, WANG Yang and LIU Cui China University of Geosciences, Beijing 100083 and Key Laboratory of Lithospheric Tectonics and Lithoprobe Techniques, Ministry of Education of China | 2004 | Acta Geologica Sinica(English Edition)2004，78，1： | 35 |
| 9 | Auxin-Cytokinin Interaction Regulates Meristem Development显示文摘植物荷尔蒙调整植物生长和开发的许多方面。植物生长素和细胞激动素以很长时间著名 synergistically 或反对地行动控制几个重要发展过程,例如分裂组织的形成和维护。在过去几年,令人激动的进步被取得了揭示位于 auxincytokinin 行动和相互作用下面的分子的机制。在这评论,我们将简短讨论在植物生长素和细胞激动素取得生合成,植物生长素运输,和植物生长素并且细胞激动素发信号的主要进步。为在控制的这二荷尔蒙的复杂相互作用的框架射击顶端的分裂组织和根象他们的角色在一样的顶端的分裂组织形成在 vitro,机关新生是这评论的主要焦点。 | Ying-Hua Su Yu-Bo Liu Xian-Sheng Zhang | 2011 | Molecular Plant2011，4，4： | 39 |
| 10 | Discovery of the eclogite and its petrography in the Northern Dabie Mountain显示文摘Eclogite from the Northern Dabie Mountain is a new finding by the authors. These eclogites in foliated perdotite are enveloped by banded gneiss and occur in the mafic-ultramafic rock belt. They are mainly composed of omphacite, garnet, diopside, orthopyroxene, amphibole, plagioclase and magnetite, and a small amount of rutile, spinel, olivin and 鏾rundum. The mineral association of peak metamorphism of the eclogite is omphacite+garnet+rutile. The existence of eclogite in the Northern Dabie Mountain implies that there was an eclogitic metamorphism prior to the granulitic facies one in the mafic-ultramafic rock belt. | XU Shutong LIU Yican SU Wen WANG Rucheng JIANG Laili WU Weiping | 2000 | Chinese Science Bulletin2000，45，3： | 39 |
| 11 | Relocation of the 10 March 2011 Yingjiang,China,earthquake sequence and its tectonic implications显示文摘An earthquake with MS5.8 occurred on 10 March 2011 in Yingjiang county,western Yunnan,China.This earthquake caused 25 deaths and over 250 injuries.In order to better understand the seismotectonics in the region,we collected the arrival time data from the Yunnan seismic observational bulletins during 1 January to 25 March 2011,and precisely hand-picked the arrival times from high-quality seismograms that were recorded by the temporary seismic stations deployed by our Institute of Crustal Dynamics,China Earthquake Administration.Using these arrival times,we relocated all the earthquakes including the Yingjiang mainshock and its aftershocks using the double-difference relocation algorithm.Our results show that the relocated earthquakes dominantly occurred along the ENE direction and formed an upside-down bow-shaped structure in depth.It is also observed that after the Yingjiang mainshock,some aftershocks extended toward the SSE over about 10 km.These results may indicate that the Yingjiang mainshock ruptured a conjugate fault system consisting of the ENE trending Da Yingjiang fault and a SSE trending blind fault.Such structural features could contribute to severely seismic hazards during the moderate-size Yingjiang earthquake. | Jianshe Lei Guangwei Zhang Furen Xie Yuan Li Youjin Su Lifang Liu Honghu Ma Junwei Zhang | 2012 | Earthquake Science2012，25，1： | 35 |
| 12 | Inhibition of Dual Specific Oncolytic Adenovirus on Esophageal Cancer via Activation of Caspases by a Mitochondrial-dependent Pathway显示文摘We investigated the anti-tumor effects of dual cancer specific-oncolytic adenovirus Ad-VP on esophageal cancer(EC).The anti-tumor activity of Ad-VP was compared with that of the control recombinant adenoviruses(Ad-GP,Ad-Apoptin,Ad-EGFP) in human esophageal cancer cell EC-109 and human normal liver cell L02 in vitro.In 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assays,the growth of EC-109 cells was slightly inhibited by Ad-GP,Ad-Apoptin and Ad-EGFP.However,Ad-VP induced a significant cytotoxic effect.Infection of EC-109 cells with Ad-VP resulted in a significant induction of apoptosis of them in vitro,detected by 4',6-diamidino-2-phenylindole(DAPI) or acridine orange and ethidium bromide staining.The results of Western blot and flow cytometric assay indicate the loss of mitochondrial membrane potential(ΔΨ m),the release of cytochrome c and the activation of caspase-3,6 and 7 in Ad-VP infected EC-109 cells.In contrast,all these assays show almost no effects of the recombinant adenoviruses on L02 cells.These results demonstrate that the treatment of tumors with Ad-VP selectively inhibits tumor growth and induces apoptosis of esophageal cancer cells.Ad-VP may provide a novel and powerful strategy for cancer gene therapy. | SU Jia-qiang CHI Bao-rong LI Xiao LIU Lei LIU Li-ming QI Yan-xin WANG Zhuo-yue JIN Ning-yi | 2012 | Chemical Research in Chinese Universities2012，28，3： | 38 |
| 13 | Tool Life and Surface Integrity in High-speed Milling of Titanium Alloy TA15 with PCD/PCBN Tools显示文摘Titanium alloys are widely used in aeronautics that demand a good combination of high strength, good corrosion resistance and low mass. The mechanical properties lead to challenges in machining operations such as high process temperature as well as rapidly increasing tool wear. The conventional tool materials are not able to maintain their hardness and other mechanical properties at higher cutting temperatures encountered in high speed machining. In this work, the new material tools, which are polycrystalline diamond (PCD) and polycrystalline cubic boron nitride (PCBN) tools, are used in high-speed milling of Ti-6.5Al-2Zr-1Mo-1V (TA15) alloy. The performance and wear mechanism of the tools are investigated. Compared to PCBN tool, PCD tool has a much longer tool life, especially at higher cutting speeds. Analyses based on the SEM and EDX suggest that attrition, adhesion and diffusion are the main wear mechanisms of PCD and PCBN tools in high-speed milling of TA15. Oxidation wear is also observed at PCBN tool/workpiece interface. Roughness, defects, micro-hardness and microstructure of the machined surface are investigated. The recorded surface roughness values with PCD/PCBN tools are bellow 0.3 μm at initial and steady cutting stage. Micro-hardness analysis shows that the machined surface hardening depth with PCD and PCBN tools is small. There is no evidence of sub-surface defects with PCD and PCBN tools. It is concluded that for TA15 alloy, high-speed milling can be carried out with PCD/PCBN tools. | SU Honghua LIU Peng FU Yucan XU Jiuhua | 2012 | Chinese Journal of Aeronautics2012，25，5： | 39 |
| 14 | MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines显示文摘迷走神经神经能通过“一条胆碱能的反煽动性的小径”控制煽动性的反应,它被 α 调停; 7-nicotinic 醋胆素受体(α 7nAChR ) 在巨噬细胞上。然而,连接 α 的细胞内部的机制; 7nAChR 激活和支持 inflammatory cytokine 生产遗体不好理解。在这研究,我们发现 miR-124 是由在暴露 LPS 的房间和老鼠的胆碱能的收缩筋的 upregulated。利用 miR-124 模仿并且 siRNA 击倒,我们证明 miR-124 是为胆碱能的反煽动性的行动的一个批评调停人。而且,我们的数据显示 miR-124 由指向信号变换器和抄写 3 的使活跃之物(STAT3 ) 到减少 IL-6 生产和 TNF-α 调制导致 LPS 的 cytokine 生产;变换酶(不作声) 减少 TNF-α版本。这些结果也显示 miR-124 是为煽动性的疾病的处理的一个潜在的治疗学的目标。 | Yang Sun Qi Li Huan Gui Dong-Ping Xu Yi-LiYang Ding-Feng Su Xia Liu | 2013 | Cell Research2013，23，11： | 35 |
| 15 | Ecological Species Groups and Interspecific Association of Dominant Tree Species in Daiyun Mountain National Nature Reserve显示文摘Research on the ecological species groups and interspecific association of plant species are helpful to discover species coexistence processes and mechanisms, and to more fully understand plant community structure, function, and its taxonomy. However, little is known about the ecological species groups(ESG) and the interspecific association of dominant species in Daiyun Mountain National Nature Reserve of Fujian Province, China. Therefore, the main goal of this paper is to explore the ESG using maximal tree, and to analyze interspecific associations of 32 dominant species selected from 102 sample plots using the chi-square test. The results show that:(1) 32 dominant species have a significant overall positive interspecific association, which indicates that the natural forest in Daiyun Mountain National Nature Reserve is stable,(2) The species pairs with weak associations, non-associations and positiveassociations account for 10.88%, 29.64% and 59.48% of the total 496 species pairs respectively, which suggests that the population distributions of the dominant species investigated are relatively independent,(3) The following species pairs may be useful for practical application, , , , , , , and(4) The results of clustering analysis based on the maximal tree method indicates that the 32 dominant species can be divided into 3 ESGs when λ at 0.60, that is ESGⅠ{Pinus massoniana, Cunning hamia lanceolata}, ESG Ⅱ{P. taiwanensis, R. farrerae, Enkianthus quinqueflorus}, ESG Ⅲ {C. carlesii, A. chinensis, C. eyrei, Castanopsis fabri, C. fargesii, Schima superba, Machilus thunbergii, Rhododendron latoucheae}. The results may be used for the selection of afforestation tree species in South China Forest Areas and guide the natural management of plantations. | SU Song-jin LIU Jin-fu HE Zhong-sheng ZHENG Shi-qun HONG Wei XU Dao-wei | 2015 | Journal of Mountain Science2015，12，3： | 37 |
| 16 | Inhibition of Alveolar Macrophage Pyroptosis Reduces Lipopolysaccharide-induced Acute Lung Injury in Mice显示文摘 | Dong-Dong Wu Pin-Hua Pan Ben Liu Xiao-Li Su Le-Meng Zhang Hong-Yi Tan ZU Cao Zuo-Ren Zhou Hai-Tao Li Hao-Si Li Li Huang Yuan-Yuan Li | 2015 | Chinese Medical Journal2015，，19： | 39 |
| 17 | Oceanic plate subduction history in the western Pacific Ocean:Constraint from late Mesozoic evolution of the Tan-Lu Fault Zone显示文摘The NE-to NNE-striking Tan-Lu Fault Zone(TLFZ) is the largest fault zone in East China, and a typical representative for the circum-Pacific tectonics. Its late Mesozoic evolution resulted from subduction of the Paleo-Pacific Plate,and can be used for indication to the subduction history. The TLFZ reactivated at the end of Middle Jurassic since its origination in Middle Triassic. This phase of sinistral motion can only be recognized along the eastern edge of the Dabie-Sulu orogenis,and indicates initiation of the Paleo-Pacific(Izanagi) Plate subduction beneath the East China continent. After the Late Jurassic standstill, the fault zone experienced intense sinistral faulting again at the beginning of Early Cretaceous under N-S compression that resulted from the NNW-ward, low-angle, high-speed subduction of the Izanagi Plate. It turned into normal faulting in the rest of Early Cretaceous, which was simultaneous with the peak destruction of the North China Craton caused by backarc extension that resulted from rollback of the subducting Izanagi Plate. The TLFZ was subjected to sinistral, transpressive displacement again at the end of Early Cretaceous. This shortening event led to termination of the North China Craton destruction. The fault zone suffered local normal faulting in Late Cretaceous due to the far-field, weak backarc extension. The late Mesozoic evolution of the TLFZ show repeated alternation between the transpressive strike-slip motion and normal faulting. Each of the sinistral faulting event took place in a relatively short period whereas every normal faulting event lasted in a longer period, which are related to the subduction way and history of the Paleo-Pacific Plates. | Guang ZHU Cheng LIU Chengchuan GU Shuai ZHANG Yunjian LI Nan SU Shiye XIAO | 2018 | Science China Earth Sciences2018，61，4： | 38 |
| 18 | Summary of Report on Cardiovascular Diseases in China,2012显示文摘The prevalence of cardiovascular diseases(CVDs)is associated with the socioeconomic prosperity,lifestyle changes,accelerated process of ageing and urbanization.The prevalence of CVDs is continuously increasing in China and will remain an upward trend in the next 10 years.CVDs are the leading cause of death for Chinese in both urban area and rural area. | WANG Wen HU Sheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Yong Jun WU Zhao Su CHEN Wei Wei YANG Jin Gang MALi Yuan LIU Ming Bo For the editorial board | 2014 | Biomedical and Environmental Sciences2014，27，7： | 31 |
| 19 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 20 | Recent advances in friction and lubrication of graphene and other 2D materials:Mechanisms and applications显示文摘Two-dimensional materials having a layered structure comprise a monolayer or multilayers of atomic thickness and ultra-low shear strength.Their high specific surface area,in-plane strength,weak layer-layer interaction,and surface chemical stability result in remarkably low friction and wear-resisting properties.Thus,2D materials have attracted considerable attention.In recent years,great advances have been made in the scientific research and industrial applications of anti-friction,anti-wear,and lubrication of 2D materials.In this article,the basic nanoscale friction mechanisms of 2D materials including interfacial friction and surface friction mechanisms are summarized.This paper also includes a review of reports on lubrication mechanisms based on the film-formation,self-healing,and ball bearing mechanisms and applications based on lubricant additives,nanoscale lubricating films,and space lubrication materials of 2D materials in detail.Finally,the challenges and potential applications of 2D materials in the field of lubrication were also presented. | Lincong LIU Ming ZHOU Long JIN Liangchuan LI Youtang MO Guoshi SU Xiao LI Hongwei ZHU Yu TIAN | 2019 | Friction2019，7，3： | 29 |
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