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| 1 | Management of entecavir-resistant chronic hepatitis B with adefovir-based combination therapies显示文摘AIM: To evaluate the long-term efficacy adefovir(ADV)-based combination therapies in entecavir(ETV)-resistant chronic hepatitis B(CHB) patients. METHODS: F i fty CHB pat ient s wi t h genotypic resistance to ETV at 13 medical centers in South Korea were included for the analysis. All the patients received rescue therapy with the combination of ADV plus ETV(ADV/ETV,n = 23) or ADV plus lamivudine(LMV)(ADV/LMV,n = 27) for more than 12 mo. Patients were monitored at least every 3-4 mo during ADV-based combination therapy by clinical examination as well as biochemical and virological assessments. Hepatitis B virus(HBV) DNA levels were measured by realtime PCR and logarithmically transformed for analysis. Cumulative rates of virologic response(VR; HBV DNA < 20 IU/m L) were calculated using the Kaplan-Meier method,and the difference was determined by a logrank test. Multivariate logistic regression and Cox proportional hazards models were used to identify independent risk factors significantly associated with short-term and long-term VR,respectively.RESULTS: Baseline median HBV DNA levels were 5.53(2.81-7.63) log10 IU/m L. The most commonly observed ETV genotypic mutation sites were rt184 and rt202. Patients were treated for a median of 27(12-45) mo. Overall,cumulative VR rates at 6,12,24,and 36 mo were 26%,36%,45%,and 68%,respectively. Patients treated with the ADV/ETV combination showed higher cumulative VR rates(35%,43%,65%,and 76%,respectively) than those with the ADV/LAM combination(18%,30%,30%,and 62%,respectively; P = 0.048). In the multivariate analysis,low baseline HBV DNA levels(< 5.2 log10 IU/m L) and initial virologic response at 3 mo(IVR-3; HBV DNA < 3.3 log10 IU/m L after 3 mo) were independent predictive factors for VR. Patients with favorable predictors achieved cumulative VR rates up to 90% at 36 mo. During the same period,the cumulative incidence of virologic breakthrough was as low as 6% in patients with the both favorable predictors.CONCLUSION: If tenofovir is not available,ADV/ETV combination could be considered in ETV-resistant patients with low HBV DNA titers,and may becontinued if IVR-3 is achieved. | Hyoung Su Kim Hyung Joon Yim Myoung Kuk Jang Ji Won Park Sang Jun Suh Yeon Seok Seo Ji Hoon Kim Bo Hyun Kim Sang Jong Park Sae Hwan Lee Sang Gyune Kim Young Seok Kim Jung Il Lee Jin-Woo Lee In Hee Kim Tae Yeob Kim Jin-Wook Kim Sook-Hyang Jeong Young Kul Jung Hana Park Seong Gyu Hwang | 2015 | World Journal of Gastroenterology2015，21，38： | 13 |
| 2 | Phase I study of weekly docetaxel and cisplatin concurrent with thoracic radiotherapy in stage III non-small-cell lung cancer显示文摘 | Hong-Gyun Wu Yung-Jue Bang Eun Kyung Choi Yong Chan Ahn Young Whan Kim Tae-Hwan Lim Cheolwon Suh Keunchil Park Charn Il Park | 2002 | International Journal of Radiation Oncology Biology Physics2002，，1： | 1 |
| 3 | Adefovir and Lamivudine Combination Therapy in Patients with Entecavir-Resistant Chronic Hepatitis B: Antiviral Responses and Evolution of Mutations显示文摘 | Yim Hyung Joon Lee Hyun Jung Suh Sang Jun Seo Yeon Seok Kim Chang Wook Lee Chang Don Park Sang Hoon Lee Myung Seok Park Choong Kee Chae Hee Bok Kim Moon Young Baik Soon Koo Kim Yun Soo Kim Ju Hyun Lee Jung Il Lee Jin Woo Hong Sun Pyo Um | 2014 | Intervirology2014，，5： | 1 |
| 4 | Saccular damage in patients with idiopathic sudden sensorineural hearing loss without vertigo显示文摘 | Seok Min Hong Jae Yong Byun Chan Hum Park Jun Ho Lee Moon Suh Park Chang Il Cha | 2008 | Otolaryngology - Head and Neck Surgery2008，，4： | 1 |
| 5 | CD11b+ Gr1+ bone marrow cells ameliorate liver fibrosis by producing interleukin‐10 in mice显示文摘 | Yang‐Gun Suh Ja Kyung Kim Jin‐Seok Byun Hyon‐Seung Yi Young‐Sun Lee Hyuk Soo Eun So Yeon Kim Kwang‐Hyub Han Kwan Sik Lee Gregg Duester Scott L. Friedman Won‐Il Jeong | 2012 | Hepatology2012，，5： | 1 |
| 6 | Recurrence of hepatitis B is associated with cumulative corticosteroid dose and chemotherapy against hepatocellular carcinoma recurrence after liver transplantation显示文摘 | Nam‐Joon Yi Kyung‐Suk Suh Jai Young Cho Choon Hyuck Kwon Kwang‐Woong Lee Jae Won Joh Suk‐Koo Lee Soon Il Kim Kuhn Uk Lee | 2007 | Liver Transpl2007，，3： | 1 |
| 7 | Hypertension and stroke in Asia:prevalence, control and strategies in developing countries for prevention显示文摘 | Singh RB Suh IL Singh VP | 2000 | J Hum Hypertens2000，14，： | 1 |
| 8 | Hypertension and stroke in Asia: prevalence, control and strategies in developing countries for prevention 显示文摘 | Singh RB Suh IL Singh VP | 2000 | Journal of human hypertension2000，，14： | 1 |
| 9 | Phase II study of radiotherapy with three-dimensional conformal boost concurrent with paclitaxel and cisplatin for Stage IIIB non–small-cell lung cancer显示文摘 | Young Seok Kim Sang Min Yoon Eun Kyung Choi Byong Yong Yi Jong Hoon Kim Seung Do Ahn Sang-wook Lee Seong Soo Shin Jung Shin Lee Cheolwon Suh Sang-We Kim Dong Soon Kim Woo Sung Kim Heon Joo Park Charn Il Park | 2005 | International Journal of Radiation Oncology, Biology, Physics2005，，1： | 1 |
| 10 | A visual servoing algorithm using fuzzy logics and fuzzy-neural networks显示文摘 | Il Hong Suh Tae Won Kim | 2000 | Mechatronics2000，10，： | 1 |
| 11 | Association between polymorphisms of Myf5 and POU1F1 genes with growth and carcass traits in Hanwoo (Korean cattle)显示文摘 | Jiyeon Seong Jae Oh Il Cheong Kun Lee Hak Lee Dong Suh Gwang Jeon Kyung Park Hong Kong | 2011 | Genes & Genomics2011，，4： | 1 |
| 12 | Atypical basal ganglia germinoma presenting as cerebral hemiatrophy: diagnosis and follow-up with 11 C-methionine positron emission tomography显示文摘 | Jeehun Lee Bo Lyun Lee Keon Hee Yoo Ki Woong Sung Hong Hoe Koo Su Jin Lee Joon Young Choi Kyung-Han Lee Jung Il Lee Hyung-Jin Shin Ji Hye Kim Yeon Lim Suh Ke Hyang Lee Munhyang Lee | 2009 | Child’s Nervous System2009，，1： | 1 |
| 13 | Usefulness of cholangioscopy in patients with focal stricture of the intrahepatic duct unrelated to intrahepatic stones显示文摘 | Dong Wan Seo Myung Hwan Kim Sung Koo Lee Seung Jae Myung Gyeong Hoon Kang Hyun Kwon Ha Dong-Jin Suh Young Il Min | 1999 | Gastrointestinal Endoscopy1999，，： | 1 |
| 14 | A Ds-insertion mutant of OSH6 (Oryza sativa Homeobox 6) exhibits outgrowth of vestigial leaf-like structures, bracts, in rice显示文摘 | Sung Han Park Chul Min Kim Byoung Il Je Su Hyun Park Soon Ju Park Hai Long Piao Yuan-hu Xuan Mi Sook Choe Kouji Satoh Shoshi Kikuchi Kon Ho Lee Young Soon Cha Byung Ohg Ahn Hyeon So Ji Doh Won Yun Myung Chul Lee Seok-cheol Suh Moo Young Eun Chang-deok Han | 2007 | Planta2007，，1： | 1 |
| 15 | Blood Pressure Is a Major Risk Factor for Renal Death: An Analysis of 560 352 Participants From the Asia-Pacific Region显示文摘 | Conall M. O?Seaghdha Vlado Perkovic Tai Hing Lam Stella McGinn Federica Barzi Dong Feng Gu Alan Cass Il Suh Paul Muntner Graham G. Giles Hirotsugu Ueshima Mark Woodward Rachel Huxley | 2009 | Hypertension2009，，3： | 1 |
| 16 | Cholangioscopic findings in bile duct tumors显示文摘 | Dong Wan Seo Sung Koo Lee Kyo Sang Yoo Gyeong Hoon Kang Myung Hwan Kim Dong-Jin Suh Young Il Min | 2000 | Gastrointestinal Endoscopy2000，，5： | 1 |
| 17 | Hypertension and stroke in Asia: prevalence, control and strategies in developing countries for prevention显示文摘 | Singh RB Suh IL Singh VP | 2000 | J Hum Hypertens2000，14，： | 1 |
| 18 | Hypertension and stroke in Asia: prevalence, control and strategies in devel- oping countries for prevention 显示文摘 | Singh RB Suh IL Singh VP | 2000 | J Human Hypertens2000，14，1011： | 1 |
| 19 | Hypertension and stroke in Asia:prevalence,control and strategies in developing countries for prevention显示文摘 | Singh RB Suh IL Singh VP | 2000 | J Human Hypertens2000，14，10： | 1 |
| 20 | Hypertension and stroke in Asia: prevalence, control and strategies in developing countries for prevention 显示文摘 | Singh RB Suh IL Singh BP | 2000 | Journal of human hypertension2000，14，： | 1 |
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