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您的检索式：作者名="Sumanta De"
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| 1 | Pentoxifylline versus prednisolone for severe alcoholic hepatitis:A randomized controlled trial显示文摘AIM:To compare the efficacy of pentoxifylline and prednisolone in the treatment of severe alcoholic hepatitis,and to evaluate the role of different liver function scores in predicting prognosis.METHODS:Sixty-eight patients with severe alcoholic hepatitis(Maddrey score≥32)received pentoxifylline(n=34,groupⅠ)or prednisolone(n=34,groupⅡ) for 28 d in a randomized double-blind controlled study,and subsequently in an open study(with a tapering dose of prednisolone)for a total of 3 mo,and were followed up over a period of 12 mo.RESULTS:Twelve patients in groupⅡdied at the end of 3 mo in contrast to five patients in groupⅠ.The probability of dying at the end of 3 mo was higher in groupⅡas compared to groupⅠ(35.29%vs 14.71%,P=0.04;log rank test).Six patients in groupⅡ developed hepatorenal syndrome as compared to none in groupⅠ.Pentoxifylline was associated with a significantly lower model for end-stage liver disease(MELD)score at the end of 28 d of therapy(15.53±3.63 vs 17.78±4.56,P=0.04).Higher baseline Maddrey score was associated with increased mortality.CONCLUSION:Reduced mortality,improved risk-benefit profile and renoprotective effects of pentoxifylline compared with prednisolone suggest that pentoxifylline is superior to prednisolone for treatment of severe alcoholic hepatitis. | Binay Krishna De Subhabrata Gangopadhyay Deep Dutta Sumanta Das Baksi Adyapad Pani Pramit Ghosh | 2009 | World Journal of Gastroenterology2009，15，13： | 26 |
| 2 | Molecular differentiation of cryptic stage of Echinococcus granulosus and Taenia species from faecal and environmental samples显示文摘Objective:To differentiate cryptic stage of Echinococcus granulosus(E.granulosus) and Taenia by PCR-RFLP and sequence information of amplicon.Methods:DNA were isolated from metacestodes stage of Taenia and E.granulosus using DNA isolation kit(Q-BIOgene kit,USA), the amplified and purified DNA product was then cloned and sent for sequencing.The generating sequence information was used for amplicons identification.Results:Out of 112 faecal and environmental samples,16 exhibited positive result.The product size of amplicon positive for E.granulosus was 310 bp;whereas,for Taenia spp.sizes varied from 379 to 388 bp.Restriction pr of ile of actinⅡwith Csp61 also differed Taenia spp.and E.granulosus.Conclusions:The result of the study indicated that,the primers were useful to differentiate cryptic stage of the two genera which is yet to be reported earlier. | Diganta Pan Sumanta De Asit Kumar Bera Subhashis Bandyopadhyay Subrata Kumar Das Debasis Bhattacharya | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 0 |
| 3 | Intra-species sequence variability in 28s rRNA gene of Oesophagostomum venulosum isolated from goats of West Bengal,India.显示文摘Objective:To identify genotypes of Oesophagostmum venulosum(O.venulosum) prevailing in West Bengal,India by comparing variation of nucleotide sequences among 28S rRNA.Methods: PCR amplification of partial segment of 28 S rRNA sequence and analysis of sequence amplified product by single strand conformation polymorphism(SSCP).Results:Two distinct conformers among male and female parasites were identified by PCR-SSCP analysis.Sequence analysis among conformers revealed the presence of five single nucleotide polymorphisms(SNP) in codon 64,66,86,125 and 146.Secondary RNA prediction structure showed that out of 5 SNPs,4 occurred at interior loop of RNA which confirmed evolutionary changes among isolates prevailing in this region.Conclusions:SNPs occured in different isolates of 0.venulosum might influence critical changes in rRNA folding pattern which influence evolutionary changes among isolates. | Subhasish Bandyopadhyay Asit Kumar Bera Sourav Sikdar Sumanta De Subhashree Ghosh Tanmoy Rana Samiran Bandyopadhyay Premanshu Dandapat Debasis Bhattacharya | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 0 |
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