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| 1 | Antiviral innate immunity pathways显示文摘最近的研究揭开了激活主人的二个发信号小径对病毒的感染的天生的免疫。小径之一利用像使用费的受体(TLR ) 的成员检测通过 endocytosis 进入内涵体的病毒的家庭。TLR 小径通过最终导致抄写因素 NF-kappaB, IRF3 和 IRF7 的激活的几发信号的蛋白质导致干扰素生产。另外的抗病毒的小径为细胞内部的病毒的双 stranded RNA 把 RNA helicase RIG-I 用作受体。RIG-I 通过最近识别的适配器蛋白质 MAVS 激活 NF-kappaB 和 IRF,包含居住在 mitochondrial 膜的蛋白质的一个卡片领域。MAVS 为抗病毒的天生的免疫是必要的,但是它也用作丙肝病毒(HCV ) 的一个目标,它采用病毒的朊酶劈开 MAVS 离开线粒体,从而允许 HCV 逃离主人免疫系统。 | Rashu B Seth Lijun Sun Zhijian J Chen | 2006 | Cell Research2006，16，2： | 45 |
| 2 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 3 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 4 | Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation显示文摘Mesenchymal stem cell(MSC)-based treatments have shown promise for improving tendon healing and repair.MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes. Cell elongation and cytoskeletal tension have been shown to be instrumental to the process of MSC differentiation. Previous studies have shown that inhibition of stress fiber formation leads MSCs to default toward an adipogenic lineage, which suggests that stress fibers are required for MSCs to sense the environmental factors that can induce differentiation into tenocytes. As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, we examined whether the activation of this pathway was required when inducing MSC tendon differentiation using rope-like silk scaffolds. To accomplish this, we employed a loss-of-function approach by knocking out ROCK,actin and myosin(two other components of the pathway) using the specific inhibitors Y-27632, Latrunculin A and blebbistatin, respectively. We demonstrated that independently disrupting the cytoskeleton and the Rho/ROCK pathway abolished the expression of tendon differentiation markers and led to a loss of spindle morphology. Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds. | Edward Maharam Miguel Yaport Nathaniel L Villanueva Takintope Akinyibi Damien Laudier Zhiyong He Daniel J Leong Hui B Sun | 2015 | Bone Research2015，3，3： | 4 |
| 5 | 缺血性脑卒中后的中期血压变异性与临床结局的关系显示文摘本研究旨在探讨急性脑卒中患者发病7d内的中期血压变异性(blood pressure variability,BPV)与预后的关系。方法:本研究纳入873例急性缺血性脑卒中患者。通过计算发病7d内的收缩压和舒张压的变异系数来评价中期BPV。 | Wang Y Wang J Meng P Liu N Ji N Zhang G Xu B Zhou X Sun Y Xu Y Hui R He M 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 6 | 纳米光子结构软膜紫外光固化纳米压印(英文)显示文摘紫外光固化纳米压印是实现纳米结构批量复制的一种新技术.其特点是低成本和高分辨,而且可以达到极高的套刻精度.为了得到大面积图案的均匀复制,可用聚二甲基硅氧烷(PDMS)制备透光的压印软模板.其母版图案可由高分辨率电子束曝光和反应离子刻蚀的方法在硅片基底上获得,然后用浇注的方法将图案转移到PDMS上.本实验特别发展了紫外光固化纳米压印适用于软膜压印的双层膜图型转移技术.该双层膜由廉价的光胶和聚甲基丙烯酸甲脂(PMMA)构成.对光胶层的压印可用普通的光学曝光仪实现.然后再将图案用反应离子刻蚀的方法转移到PMMA层中.为了证明方案的可行性,在两种不同材料的半导体基片上压印了三角晶格的光子晶体和准晶结构的图案,并用剥离的方法将它们转移到金属薄膜上,最后成功地进行了硅片刻蚀实验.相信这一纳米制做方法对大面积纳米光子结构和光学集成芯片的制造是普遍适用的. | SHI J WANG Z M BAO K PEROZ C BELOTTI M XU L P LUO C X SUN M H ZHANG B JI H OUYANG Q CHEN Y | 2006 | 纳米技术与精密工程2006，4，3： | 2 |
| 7 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 8 | Volatile flavor constituents in roasted pork of mini-pig显示文摘 | XIE J C SUN B G ZHENG F P | 2008 | Food Chemistry2008，109，： | 1 |
| 9 | Sensitized chemiluminescence of CdTe quantum-dots on Ce( IV)-sulfite and its analytical applications 显示文摘 | SUN C Y LIU B LI J H | | Talanta0，75，2： | 1 |
| 10 | Contributors to estrogenic activity in wastewater from a large wastewater treatment plant in Beijing, China显示文摘 | SUN Q F DENG S B HUANG J | 2008 | Environmental Toxicology and Pharmacology2008，25，： | 1 |
| 11 | First-principles studies of ternary site occupancy in the C15 NbCr: Laves phase显示文摘 | YAO Q SUN J ZHANG Y JIANG B | 2006 | Acta Materialia2006，54，35： | 1 |
| 12 | Selective separation of yttrium by CA-100 in the presence of a complexing agent 显示文摘 | SUN X B WANG J P LI D Q | 2006 | Journal of Alloys and Compounds2006，，： | 1 |
| 13 | A randomized, controlled study comparing minilaparotomy versus isobaric gasless laparoscopic assisted minilaparotomy myomectomy for removal of large uterine myomas: short-term outcomes 显示文摘 | Tan J Sun Y Zhong B | 2009 | Obstet Gynecol Reprod Bio12009，145，1： | 1 |
| 14 | Phenotype-genotype con'elation in eight Chinese 17 alpha-hydroxylase/17, 20 lyase-deficiency patients with five novel mutations of CYP17A1 gene显示文摘 | Yang J Cui B Sun S | 2006 | J Clin Endocrinol Metab2006，91，9： | 1 |
| 15 | Mesh-free numerical simulation for carbon nanotubes upon bending显示文摘 | B GAO Y Z SUN J B WANG | 2010 | Ad- vanced Materials Research2010，139，： | 1 |
| 16 | Residual Stress in Silicon Carbide Particulate Reinforced Aluminum Composites显示文摘 | SUN Z M LI J B WANG Z G LI W J | 1992 | Acta Metall Mater1992，40，11： | 1 |
| 17 | Wind-blown origin of the Pliocene red clay formation in the central Loess Plateau 显示文摘 | Ding Z L Sun J M Liu T S Zhu R X Yang S L Guo B | 1998 | Earth and Planetary Science Letters1998，161，： | 1 |
| 18 | Algorithms for the quickest path problem and enumeration of quickest paths显示文摘 | RESEN J B SUN S Z | 1991 | Computers Ops Res1991，18，6： | 1 |
| 19 | Two color hybridization analysis using high density oligonucleotide arrays and energy transfer dyes显示文摘 | Hacia J Edgemon K Sun B | 1998 | Nucleic Acids Res1998，26，： | 1 |
| 20 | Leaching of heavy metals from contaminated soils using EDTA 显示文摘 | Sun B Zhao F J Lombi E | 2001 | Environ Pollut2001，113，： | 1 |
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