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| 1 | MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1显示文摘Unhealable diabetic wounds need to be addressed with the help of newer,more efficacious strategies.Exosomes combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new hope for chronic wound treatment.Here,the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch(SFP)were demonstrated to promote diabetic wound healing.Silk fibroin binding peptide(SFBP)was screened through phage display,and SFBP-Gluc-MS2(SGM)and pac-miR146a-pac fusion protein were constructed.The designed exosomes(SGM-Exos,miR146a-Exos,and SGM-miR146a-Exos)were isolated from the engineered placental mesenchymal stem cells(PMSCs)transduced with SGM or/and pac-miR146a-pac protein.Gluc signals indicated SGM-Exo@SFP markedly increased the binding rate and the stability of SGM-Exo.Moreover,the loading efficiency of miR146a in SGM-miR146a-Exos was ten-fold higher than that in miR146a-Exos.Superior to untreated,SGM-miR146a-Exo-only treated,and SFP-only treated groups,SGM-miR146a-Exo@SFP drived wound healing associated with less inflammation,collagen deposition,and neovascularization.The transcriptomics analysis suggested anti-inflammatory and regenerative effects with SGM-miR146a-Exo@SFP treatment.Here,we show efficient exosome@biomaterial-based miRNA delivery systems for regenerative medicine and tissue engineering. | Qiankun Li Wenzhi Hu Qilin Huang Jie Yang Bingmin Li Kui Ma Qian Wei Yaxi Wang Jianlong Su Mengli Sun Shengnan Cui Rungong Yang Haihong Li Xiaobing Fu Cuiping Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 2 | BiVO_(4)/TiO_(2) heterojunction with rich oxygen vacancies for enhanced electrocatalytic nitrogen reduction reaction显示文摘The large-scale production of ammonia mainly depends on the Haber-Bosch process,which will lead to the problems of high energy consumption and carbon dioxide emission.Electrochemical nitrogen fixation is considered to be an environmental friendly and sustainable process,but its efficiency largely depends on the activity and stability of the catalyst.Therefore,it is imperative to develop high-efficient electrocatalysts in the field of nitrogen reduction reaction(NRR).In this paper,we developed a BiVO_(4)/TiO_(2) nanotube(BiVO_(4)/TNT)heterojunction composite with rich oxygen vacancies as an electrocatalytic NRR catalyst.The heterojunction interface and oxygen vacancy of BiVO_(4)/TNT can be the active site of N2 dynamic activation and proton transition.The synergistic effect of TiO_(2) and BiVO_(4) shortens the proton transport path and reduces the over potential of chemical reaction.BiVO_(4)/TNT has high ammonia yield of 8.54µg·h^(−1)·cm^(−2) and high Faraday efficiency of 7.70%in−0.8 V vs.RHE in 0.1 M Na_(2)SO_(4) solution. | Yunliang Liu Peiji Deng Ruqiang Wu Ramadan A.Geioushy Yaxi Li Yixian Liu Fengling Zhou Haitao Li Chenghua Sun | 2021 | Frontiers of physics2021，16，5： | 1 |
| 3 | Effect of PAC addition on MBR process for drinking water treatment 显示文摘 | Sagbo Omer Sun Yaxi Hao Ailing Gu Ping | 2008 | Separation and PurificationTechnology2008，58，2008： | 1 |
| 4 | Effect of PAC addition on MBR process for drinking water treatment 显示文摘 | Sagbo Omer Sun Yaxi Hao Ailing | 2008 | Sep Purif Technol2008，58，3： | 1 |
| 5 | A core-satellite structured type Ⅱ heterojunction photocatalyst with enhanced CO_(2) reduction under visible light显示文摘Photocatalytic reduction of carbon dioxide into valuable chemicals is a sustainable and promising technology that alleviates the greenhouse effect and energy crisis.In this study,the Mn_(3)O_(4)/FeNbO_(4) type Ⅱ heterojunction photocatalyst with a core-satellite structure was synthesized by the facile soft chemical method.The formation of a nano-heterojunction is supposed to effectively improve light capture,charge transfer,and interfacial charge separation in the photochemical reaction.Meanwhile,the heterojunction has a good ability to capture and activate CO_(2).Our results show that the prepared Mn_(3)O_(4)/FeNbO_(4) photocatalyst exhibit obvious enhanced catalytic properties in the photocatalytic CO_(2) reduction reaction,where the CH_(4) yielding rate is 1.96 and 9.81 times those of FeNbO_(4) and Mn_(3)O_(4),respectively.The transient photovoltage test(TPV)shows that the low frequency electrons are crucial to the effective transfer of photogenerated electrons and holes in the Mn_(3)O_(4)/FeNbO_(4) nano heterojunctions.Analysis of in situ Fourier transform infrared spectroscopy(FTIR)verifies the effective CO_(2) adsorption on the Mn_(3)O_(4)/FeNbO_(4) surface and the high selectivity of CH_(4) products.These properties of the Mn_(3)O_(4)/FeNbO_(4) photocatalyst infer its broad prospects in the fields of carbon fixation and energy conservation. | Yuanyuan Cheng Yixian Liu Yunliang Liu Yaxi Li Ruqiang Wu Yongchao Du Najmeh Askari Naiyun Liu Fen Qiao Chenghua Sun Zhenhui Kang Haitao Li | 2022 | Nano Research2022，15，10： | 1 |
| 6 | Effect of PAC addition on MBR process for drinking water treatment 显示文摘 | SAGBO O SUN Yaxi HAO Ailing | 2008 | Separation and Purification Technology2008，，58： | 1 |
| 7 | Effect of PAC additionon MBR process for drinking water treatment显示文摘 | Sagbo Omer Sun Yaxi Hao Ailing | 2008 | Separation andPurification Technology2008，58，： | 1 |
| 8 | Effect of PAC addition on MBR process for drinking water treatment 显示文摘 | SAGBO O SUN Yaxi HAO Ailing | 2008 | Separation and Purification Technology2008，58，3： | 1 |
| 9 | Effect of PAC addition on MBR process for drinking water treatment 显示文摘 | SAGBO O SUN Yaxi HAO Ailing | 2008 | Separation and Purification Technology2008，58，3： | 1 |
| 10 | Effect of PAC addition on MBR process for drinking water treatment 显示文摘 | Sagbo Omer Sun Yaxi Hao Ailing | 2008 | Separation and Purification Technology2008，58，： | 1 |
| 11 | Effect of PAC addition on MBR process for drinking water treatment显示文摘 | SAGBO O SUN Yaxi HAP Ailing | 2008 | Separation and Purification Technology2008，58，3： | 1 |
| 12 | Selecting and optimizing of the heavy metal inactivator in sewage sludge composting显示文摘In sewage sludge composting,adding ash from stove(FA20)inactivated active Cu effectively and the results were significantly better than control.For Zn,Mn,Pb and Cd,satisfying results was achieved by adding ash from stove and phosphorite powder(FA20,PR10),phosphorite powder and lime(PR15,CL10),ash from stove and phosphorite powder(FA10,PR10),and ash from stove and peat(FA20,PT10).Based on their effects of inactivating available forms of heavy metals,ash from stove,phosphorite powder and peat were supposed to be effective inactivators with optimum percentages of 20%,15% and 10%(FA20,PR15,PT10). | HUANG Yaxi LI Ji LI Guoxue SUN Xue HUANG Yang XU Lianshuang | 2007 | Journal of Northeast Agricultural University(English Edition)2007，14，2： | 0 |
| 13 | Emerging rechargeable aqueous magnesium ion battery显示文摘Recently,aqueous rechargeable batteries have played an essential role in developing renewable energy due to the merits of low cost,high security,and high energy density.Among various aqueous-based batteries,aqueous magnesium ion batteries(AMIBs)have rich reserves and high theoretical specific capacity(3833 mAh cm3).However,for future industrialization,AMIBs still face many scientific issues to be solved,such as the slow diffusion of magnesium ions in the material structure,the desolvation penalty at electrode-electrolyte interfaces,the cost of water-in-salt electrolyte,the low voltage of traditional aqueous electrolyte,etc.And yet a comprehensive summary of the components of AMIBs is lacking in the research community.This review mainly introduces the exploration and development of AMIB systems and related components.We conduct an in-depth study of the cathode materials appropriate for magnesium ion batteries from their crystal structures,focusing primarily on layered structures,spinel structures,tunnel structures,and three-dimensional framework structures.We also investigate the anode materials,ranging from inorganic materials to organic materials,as well as the electrolyte materials(from the traditional electrolyte to water-in-salt electrolyte).Finally,some perspectives on ensuing optimization design for future research efforts in the AMIBs field are summarized. | Mudi Li Yaxi Ding Ying Sun Yujin Ren Jinzhang Yang Bosi Yin Hui Li Siwen Zhang Tianyi Ma | 2022 | Materials Reports(Energy)2022，2，4： | 0 |
| 14 | Enhancing photodynamic inactivation via tunning spatial constraint on photosensitizer显示文摘The critical factor of spatial constraint,provided by the external confinement(e.g.,matrix),is often overlooked during photodynamic inactivation,despite playing a crucial role in determining the molecular photophysical process and subsequent antipathogen performance.Here,as a proof-of-concept model,we employed two types of polymers with varying interaction energies with dopants to investigate the intrinsic relationship between spatial constraint and the essential excited-state behaviors of doped photosensitizer(4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)ethyl)-1-methylquinolin-1-ium iodine,TPP).Through experimental investigation and theoretical calculations,we found that TPP tends to remain in the excited state for a shorter dwell time under weaker spatial constraints due to less restricted molecular motion in polyurethane(PU) nanofibers.Consequently,the singlet oxygen(^(1)O_(2)) generated from doped-TPP shows a 9.23-fold enhancement in PU than in the polyvinylchloride(PVC) matrix.Under light irradiation,the PU@TPP nanofiber can efficiently eliminate the coronavirus MHV-A59(≥99.9997%) at a 220,000-fold higher concentration than the infected space.Its antibacterial efficacy has also been demonstrated,with a killing rate of ≥99%. | Chong Li Minghao Han Ji Gao Shuxian Wang Song-Bo Lu Yaxi Li Zhao Liu Chen Zhang Zhaojin Wang Fangliang Wang Yuang Sun Chun Loong Ho Kai Wang Yun Shen Kai Li | 2024 | Science China Chemistry2024，67，2： | 0 |
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