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| 1 | Silk materials for medical, electronic and optical applications显示文摘Silk derived from the silkworm Bombyx mori is among the most important fibrous protein biomaterials due to large-scale production from natural sources, excellent biocompatibility, unique mechanical properties and controllable degradation. Silk fibroin can be processed into a variety of formats to match different applications, such as tissue engineering, drug delivery or as the passive substrate of a bio-device. Advances in fabrication technologies provide new possibilities for the combination of silk fibroin with other nanomaterials to functionalize silk fibroin for specialized purposes, including sensing, cell visualization,resistance to ultraviolet light and provision of antibacterial properties. As the requirement for wearable and intelligent devices has become increasingly important over recent years, silk fibroin has been utilized as the active element in electronic and optical instruments. This review summarizes these recent advances in the innovative applications of silk fibroin. | FAN SuNa ZHANG Yi HUANG XiangYu GENG LiHong SHAO HuiLi HU XueChao ZHANG YaoPeng | 2019 | Science China(Technological Sciences)2019，62，6： | 4 |
| 2 | 3D Printed Gelatin Scaffold with Improved Shape Fidelity and Cytocompatibility by Using Antheraea pernyi Silk Fibroin Nanofibers显示文摘Gelatin(G)is a commonly used natural biomaterial owing to its good biocompatibility and easy availability.However,using pure gelatin as a bioink can barely achieve an ideal shape fidelity in 3D printing.In this study,Antheraea pernyi silk fibroin nanofibers(ASFNFs)with arginine-glycine-aspartic acid(RGD)peptide and partial natural silk structure are extracted and combined with pure gelatin bioink to simultaneously improve the shape fidelity and cytocompatibility of corresponding 3D printed scaffold.Results show that the optimum printing temperature is 30℃ for these bioinks.The printed filaments using 16G/4ASFNFs bioink(16wt%gelatin and 4wt%ASFNFs)demonstrate better morphology and larger pore size than those printed by pure gelatin bioink(20G,20wt%gelatin),thus successfully improve the shape fidelity and porosity of the 3D printed scaffold.The 16G/4ASFNFs scaffold also demonstrate higher swelling ratio and faster degradation rate than the pure gelatin scaffold.Moreover,the cell viability and proliferation ability of Schwann cells cultured on the 16G/4ASFNFs scaffold are significantly superior than those cultured on the pure 20G scaffold.The ASFNFs enhanced 16G/4ASFNFs scaffold reported here are expected to be a candidate with excellent potential for biomedical applications. | Shengzhi Zou Suna Fan Ana L.Oliveira Xiang Yao Yaopeng Zhang Huili Shao | 2022 | Advanced Fiber Materials2022，4，4： | 2 |
| 3 | 显示文摘 | Fan Weiliu Song Xinyu Suna Sixiu | 2007 | Journal of Solid State Chemistry2007，180，： | 1 |
| 4 | Effects of compound stimulation of fluid shear stress plus ultrasound on stem cell proliferation and osteogenesis显示文摘Bone tissue with strong adaptability is often in a complex dynamical microenvironment in vivo,which is associated with the pathogenesis and treatment of orthopedic diseases.Therefore,it is of great significance to investigate the effects of corresponding compound stimulation on cell behaviors.Herein,a fluid shear stress(FSS)plus ultrasound stimulation platform suitable for cell studies based on a microfluidic chip was constructed and bone marrow mesenchymal stem cell(BMSC)was chosen as a model cell.The proliferation and osteogenesis of BMSCs under the compound stimulation of FSS plus ultrasound in growth medium without any soluble induction factors were firstly investigated.Single FSS stimulation and static culture conditions were also examined.Results illustrated that suitable single FSS stimulation(about 0.06 dyn/cm^(2))could significantly enhance cell proliferation and osteogenesis simultaneously when compared to the static control,while greater FSS mitigated or even restricted these enhancing effects.Interestingly,ultrasound stimulation combined with this suitable FSS stimulation further accelerated cell proliferation as the intensity of ultrasound increasing.As for the osteogenesis under compound stimulation,it was relatively restricted under lower ultrasound intensity(about 0.075W/cm^(2)),while promoted when the intensity became higher(about 1.75W/cm^(2)).This study suggests that both the cell proliferation and osteogenesis are very responsive to the magnitudes of FSS and ultrasound stimulations and can be both significantly enhanced by proper combination strategies.Moreover,these findings will provide valuable references for the construction of effective cell bioreactors and also the treatment of orthopedic diseases. | Lingzhi Jing Suna Fan Xiang Yao Yaopeng Zhang | 2021 | Regenerative Biomaterials2021，8，6： | 1 |
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