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| 1 | Prospective real-time evaluation of diagnostic performance using endocytoscopy in differentiating neoplasia from nonneoplasia for colorectal diminutive polyps(≤ 5 mm)显示文摘AIM To clarify the diagnostic performance of endocytoscopy for differentiation between neoplastic and nonneoplastic colorectal diminutive polyps.METHODS Patients who underwent endocytoscopy between October and December 2016 at Sano Hospital were prospectively recruited. When diminutive polyps(≤5 mm) were detected, the lesions were evaluated by endocytoscopy after being stained with 0.05% crystal violet and 1% methylene blue. The diminutivepolyps were classified into five categories(EC 1 a, 1 b, 2, 3 a, and 3 b). Endoscopists were asked to take a biopsy from any lesion diagnosed as EC1 b(indicator of hyperplastic polyp) or EC2(indicator of adenoma). We have assessed the diagnostic performance of endocytoscopy for EC2 and EC1 b lesions by comparison with the histopathology of the biopsy specimen. RESULTS A total of 39 patients with 63 diminutive polyps were analyzed. All polyps were evaluated by endocytoscopy. The mean polyp size was 3.3 ± 0.9 mm. Among the 63 diminutive polyps, 60 were flat and 3 were pedunculated. The mean time required for EC observation, including the time for staining with crystal violet and methylene blue, was 3.0 ± 1.9 min. Histopathologic evaluation showed that 13 polyps were hyperplastic and 50 were adenomas. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of EC2 for adenoma compared with EC1 b for hyperplastic polyp were 98.0%, 92.3%, 96.8%, 98.0% and 92.3%, respectively. There were only two cases of disagreement between the endoscopic diagnosis made by endocytoscopy and the corresponding histopathological diagnosis.CONCLUSION Endocytoscopy showed a high diagnostic performance for differentiating between neoplastic and non-neoplastic colorectal diminutive polyps, and therefore has the potential to be used for 'real-time histopathology'. | Takahiro Utsumi Yasushi Sano Mineo Iwatate Hironori Sunakawa Akira Teramoto Daizen Hirata Santa Hattori Wataru Sano Noriaki Hasuike Kazuhito Ichikawa Takahiro Fujimori | 2018 | World Journal of Gastrointestinal Oncology2018，10，4： | 4 |
| 2 | Japanese guidelines for themanagement of respiratory infectious diseases in children 2007 withfocus on pneumonia显示文摘 | Uehara S Sunakawa K Eguchi H | 2011 | Pediatr Int2011，53，2： | 1 |
| 3 | The possibility of dow el removal by pulsed Nd: YAG laser irradiation显示文摘 | Takashina M Ebihara A Sunakawa M | 2002 | Laser Surg Med2002，31，4： | 1 |
| 4 | Colonization of denture plaque by respiratory pathogens in dependent elderly显示文摘 | Sumi Y Miura H Sunakawa M | 2002 | Gerodontology2002，19，1： | 1 |
| 5 | Meningitis caused by Enterococeus gallinarum in patieots with ventriculoperitoneal shunts显示文摘 | Takayama Y Sunakawa K Akahoshi T | 2003 | J Infect Chernother2003，9，4： | 1 |
| 6 | Cycle analysis of low and high H2 utilization SOFC/gas turbine combined cycle for CO2 recovery显示文摘 | Takuto Araki Takuya Taniuchi Dalsuke Sunakawa Mitsuyuki Nagabama Kazuo Onda Tom Kate | 2007 | Journal of Power Sources2007，171，2007： | 1 |
| 7 | Direct Inhibition and Down-regulation by Uremic Plasma Components of Hepatic Uptake Transporter for SN-38, an Active Metabolite of Irinotecan, in Humans显示文摘 | Ken-ichi Fujita Tomoko Sugiura Hidenori Okumura Saki Umeda Noritaka Nakamichi Yusuke Watanabe Hiromichi Suzuki Yu Sunakawa Ken Shimada Kaori Kawara Yasutsuna Sasaki Yukio Kato | 2014 | Pharmaceutical Research2014，，1： | 1 |
| 8 | Association of variants in genes encoding for macrophage-related functions with clinical outcome in patients with locoregional gastric cancer显示文摘 | Sunakawa Y Stremitzer S Cao S | 2015 | Ann 0ncol2015，26，2： | 1 |
| 9 | CT of blunt abdominal trauma in adults显示文摘 | Mizunuma K Sunakawa Y Otani Y | 1990 | Radiology1990，205，3： | 1 |
| 10 | A histological study on healing process of palate wound with bone denudation 显示文摘 | Oima H Sunakawa H Arakaki K | 1998 | J Jpn Cleft Palate Assoc1998，23，： | 1 |
| 11 | Colonization of denture plague by raspiratory pathogens in dependent elderly显示文摘 | Sumi Y Miura H Sunakawa M | 2002 | Gerodontology2002，19，1： | 1 |
| 12 | High-quality InGaN MQW on Low-dislocation-density GaN Substrate Grown by Hydride Vapor PhaseEpit axy显示文摘 | Sasaoka C Sunakawa H Kimura A | 1998 | Journal of Crystal Growth1998，189，190： | 1 |
| 13 | Postoperative long- term results in total correction of tetralogy of Fallot: Hemodynamics and cardiac function 显示文摘 | Oku H Shirontani H Sunakawa A | 1986 | Ann Thorac Surg1986，41，4： | 1 |
| 14 | The possibility of dowel removal by pulsed Nd:YAG laser irradiation显示文摘 | Takashina M Ebihara A Sunakawa M | 2002 | Lasers Surg Med2002，31，4： | 1 |
| 15 | Regorafenib in Japanese patients with solid tumors: phase I study of safety, efficacy, and phannacokinetics 显示文摘 | Sunakawa Y Furuse J Okusaka T | 2014 | Investi New Drugs2014，32，1： | 1 |
| 16 | A histological study on healing process of palate wound with bone denudation显示文摘 | Gima H Sunakawa H Arakaki K | 1998 | J Jpn Cleft Palate Assoc1998，23，： | 1 |
| 17 | Appropriate use of anti-MRSA drugs显示文摘 | Sunakawa K | 2007 | Jpn J Antibiot2007，60，1： | 1 |
| 18 | Japanese guidelines for the management of respiratory infectious diseases in children 2007 with fo- cus on pneumonia显示文摘 | Uehara S Sunakawa K Eguchi H | 2011 | Pediatrics International2011，53，1： | 1 |
| 19 | Cycle Analysis of Low and High H2 Utilization SOFC/gas Turbine Combined Cycle for CO2 Recovery 显示文摘 | Takuto Araki Takuya Taniuchi Daisuke Daisuke Sunakawa | 2007 | Journal of Power Sources2007，，171： | 1 |
| 20 | Japanese guidelines for the management of respiratorv infectious diseases in children 2007with focus on pneumonia显示文摘 | Uehara S Sunakawa K EgIlchi H | 2011 | Pediatr Int2011，53，： | 1 |
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