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| 1 | Physical activity support or weight loss counseling for nonalcoholic fatty liver disease?显示文摘AIM:To determine the clinical effectiveness of intense psychological support to physical activity(PA)in nonalcoholic fatty liver disease(NAFLD),compared with cognitive-behavioral treatment(CBT).METHODS:Twenty-two NAFLD cases received support to exercise,tailored to their motivational needs(PA group).The effects on body weight,physical fitness[6-min walk test,VO2max and the PA-rating(PA-R)questionnaire]and body fat(fatty liver indices and visceral adiposity index)were compared with data obtained in 44 NAFLD subjects enrolled in a CBT program for weight loss,after adjustment for propensity score,calculated on baseline data.Measurements were performed at baseline,at 4-mo and one-year follow-up.Changes in anthropometric,biochemical and PA parameters were tested by repeated measurement ANOVA.Outcome results were tested by logistic regression analysis.RESULTS:At the end of the intensive program,BMI was less significantly reduced in the PA group(-1.09±1.68 kg/m2 vs-2.04±1.42 kg/m2 in the CBT group,P=0.019)and the difference was maintained at 1-year follow-up(-0.73±1.63 vs-1.95±1.88,P=0.012)(ANOVA,P=0.005).PA-R was similar at baseline,when only 14%of cases in PA and 36%in CBT(P=0.120)recorded values≥3.At 4 mo,a PA-R≥3 was registered in 91%of PA and 46%of CBT,respectively(P<0.001)and PA-R≥5(up to 3 h/wk of moderate-toheavy intensity physical activity)was registered in 41%of PA and only 9%of CBT group(P<0.007).The6-min walk test increased by 139±26 m in PA and by only 43±38 m in CBT(P<0.001)and VO2max by8.2±3.8 mL/kg per minute and 3.3±2.7 mL/kg per minute,respectively(P<0.002).After adjustment for propensity,weight loss>7%was significantly associated with CBT group at one year(OR=6.21;95%CI:1.23-31.30),whereas PA-R>3 was associated with PA group(10.31;2.02-52.63).Liver enzymes decreased to values within normal limits in 36%of PA cases and61%of CBT(P<0.070).Estimated liver fat(Kotronen index)fell below the fatty liver threshold in 36%of PA and 34%and CBT cases at one-year(not different).Also the fatty liver index and the visceral adiposity index improved to a similar extent.CONCLUSION:Intensive psychological counseling for PA produces hepatic effects not different from standard CBT,improving physical fitness and liver fat independent of weight loss.Strategies promoting exercise are worth and effective in motivated patients,particularly in lean NAFLD patients where large weight loss cannot be systematically pursued. | Luca Montesi Chiara Caselli Elena Centis Chiara Nuccitelli Simona Moscatiello Alessandro Suppini Giulio Marchesini | 2014 | World Journal of Gastroenterology2014，20，29： | 3 |
| 2 | The Role of Lifestyle Change in the Prevention and Treatment of NAFLD显示文摘 | Elena Centis Rebecca Marzocchi Alessandro Suppini Riccardo Dalle Grave Nicola Villanova Ingrid J Hickman Giulio Marchesini | 2013 | Current Pharmaceutical Design2013，，29： | 2 |
| 3 | Sufentanil supplementation of sevoflurane during induction of anaesthesia: a randomized study显示文摘 | MEAUDRE E BORET H SUPPINI A | 2004 | Eur J Anaesthesiol2004，21，10： | 1 |
| 4 | Sufentanil supplementation of sevoflurane during induction of anaesthesia:arandomized study显示文摘 | Meaudre E Boret H Suppini A | 2004 | Eur J Anaesthesiol2004，21，10： | 1 |
| 5 | Sufentanil supplementation of sevoflurane during induction of anaesthesia: a randomized study显示文摘 | Meaudre E Boret H Suppini A | 2004 | Eur J Anaesthesiol2004，21，10： | 1 |
| 6 | Sufentanil supplementation of sevoflurane during induction of anaesthesia: a randomized study 显示文摘 | Meaudre E Boret H Suppini A | 2004 | Eur J Anaesthesiol2004，21，10： | 1 |
| 7 | Sufentanil supplementation of sevoflurane during induction of anaesthesia:a randomized study 显示文摘 | Meaudre E Boret H Suppini A | 2004 | Eur J Anaesthesio12004，21，： | 1 |
| 8 | Sufen lan il supp lem en ta tion of sevo furane du ring induction of anaesthesia a random ized study显示文摘 | Meaudre E Boret H Suppini A | 2004 | Eur J Anaesthesio2004，21，10： | 1 |
| 9 | Sufentanil supplementation of sevoflurane during induc tion of anaesthesia: a randomized study显示文摘 | Meaudre E Borer H Suppini A Sallaberry M genefice S Palm ier B | 2004 | Eur J Anaesthesiol2004，21，： | 1 |
| 10 | Behavior therapy for nonalcoholic fatty liver disease:the need for a multidisciplinary approach显示文摘 | Bellentani S Dalle Grave R Suppini A | | Hepatology0，，： | 1 |
| 11 | Sufentanil supplementation of sevoflurane during induction of anaesthesia:a randomized study显示文摘 | Meaudre E Boret H Suppini A | 2004 | EurJ Anaesthesiol2004，21，10： | 1 |
| 12 | Sufentanil supplementation of sevoflurane duing induction of anaesthesia: a randomized study显示文摘 | Meaudre E Boret H Suppini A | 2004 | Eur J Anaesthesiol2004，21，10： | 1 |
| 13 | Behavior therapy for nonalcoholic fatty liver disease:The need for a multidisciplinary approach显示文摘 | Bellentani S Dalle Grave R Suppini A | 2008 | Hepatology2008，47，2： | 1 |
| 14 | Sufentanil supplementation of sevoflurane during induction of anaesthesia : a randomized study 显示文摘 | Meaudre E Boret H Suppini A | 2004 | Eur J Anaesthesiol2004，21，10： | 1 |
| 15 | Sufentanil supplementation of sevoflurane during induction of anaesthesia:a randomized study显示文摘 | Meaudre E Boret H Suppini A | | 0，，10： | 1 |
| 16 | Sufentanil supplementation of sevoflurane during induction of anaesthesia: a randomized study显示文摘 | Meaudre E Boret H Suppini A | 2004 | Eur J Anaesthesiol2004，21，10： | 1 |
| 17 | Sufentanil supplemen-tation of sevoflurane during induction of anaesthasia: a ran- domized study显示文摘 | Meaudre E Boret H Suppini A | 2004 | EurJAnesthesiol2004，21，10： | 1 |
| 18 | Sufen lan il supp lem en ta tion of sevo furane du ring induction of anaesthesia a random ized study显示文摘 | Meaudre E Borer H Suppini A | 2004 | Ear J Anaesthesio2004，21，10： | 1 |
| 19 | Sufentanil supplementation of sevoflurane during induction of anaesthesia: a randomized study 显示文摘 | Meaudre E Boret H Suppini A | 2004 | Eur J Anaesthsiology2004，21，10： | 1 |
| 20 | Sufentanil supplemen- tation of sevoflurane during induction of anaesthesia : a ran- domized study显示文摘 | Meaudre E Borer H Suppini A | 2004 | Eur J Anaesthesiol2004，21，10： | 1 |
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