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| 1 | Multi-institutional retrospective analysis of FOLFIRI in patients with advanced biliary tract cancers显示文摘BACKGROUND Gemcitabine plus platinum is the standard of care first-line treatment for advanced biliary tract cancers(BTC).There is no established second-line therapy,and retrospective reviews report median progression-free survival(PFS)less than 3 mo on second-line therapy.5-Fluorouracil plus irinotecan(FOLFIRI)is a commonly used regimen in patients with BTC who have progressed on gemcitabine plus platinum,though there is a paucity of data regarding its efficacy in this population.AIM To assess the efficacy of FOLFIRI in patients with biliary tract cancers.METHODS We retrospectively identified patients with advanced BTC who were treated with FOLFIRI at MD Anderson,University of Michigan and Mayo Clinic in Jacksonville.Data were collected on patient demographics,BTC subtype,response per RECIST v1.1,progression and survival.RESULTS Ninety-eight patients were included of which 74(75%)had metastatic and 24(25%)had locally advanced disease at the time of treatment with FOLFIRI.The median age was 60(range,22-86)years.The number of patients with extrahepatic cholangiocarcinoma,gall bladder cancer and intrahepatic cholangiocarcinoma were 10,17 and 71,respectively.FOLFIRI was used as 1st,2nd,3rd or 4th–Nth lines in 8,50,36 and 4 patients,respectively.Median duration on FOLFIRI in the entire cohort was 2.2(range,0.5-8.4)mo.The median PFS and overall survival were 2.4(95%confidence interval(CI):1.7-3.1)and 6.6(95%CI:4.7-8.4)mo,respectively.Median PFS for patients treated with FOLFIRI in 1st,2nd,3rd or 4th–Nth lines were 3.1,2.5,2.3 and 1.5 mo,respectively.Eighteen patients received concurrent bevacizumab(n=13)or EGFR-targeted therapy(n=5)with FOLFIRI,with a median PFS of 2.7 mo(95%CI:1.7-5.1).CONCLUSION In this largest multi-institution retrospective review of 98 patients with BTC treated with FOLFIRI,efficacy appears to be modest with outcomes similar to other cytotoxic chemotherapy regimens. | Jonathan D Mizrahi Valerie Gunchick Kabir Mody Lianchun Xiao Phanikeerthi Surapaneni Rachna T Shroff Vaibhav Sahai | 2020 | World Journal of Gastrointestinal Oncology2020，12，1： | 2 |
| 2 | Oxidative stress and an- tioxidant enzyme activity in South Indian male smokers with chron- ic obstructive pulmonary disease 显示文摘 | Arja C Surapaneni KM Raya P | 2013 | Respimlogy2013，18，： | 1 |
| 3 | Silberzweiq JE Cesarean section scar diverticulum: ap- pearance on hysterosalp in geography显示文摘 | Surapaneni K | 2008 | AIR Am J Roentqnol2008，190，4： | 1 |
| 4 | Status of lipid peroxidation, glutathione, ascorbie acid, vitamin E and antioxidant enzymes in patients with osteoarthritis显示文摘 | Surapaneni KM Venkataramana G | 2007 | Indian J Med Sci2007，61，1： | 1 |
| 5 | Cesarean section scar diverticulum:appearance on hysterosal pingography显示文摘 | Surapaneni K Silberzweig JE | 2008 | AJR Am J Roentgenol2008，190，4： | 1 |
| 6 | Cesarean section scar diverticulum:appearance on hysterosalpingography 显示文摘 | Surapaneni K Silberzweig JE | 2008 | AJR Am J Roentgenol2008，190，4： | 1 |
| 7 | Cesarean section scar diver- ticulum: appearance on hysterosalpingography显示文摘 | Surapaneni K Silberzweig J E | 2008 | AJR Am J Roentgenol2008，190，4： | 1 |
| 8 | Potassium in the soils of New Zealand-a review显示文摘 | Kirkman J H Basker A Surapaneni A | 1994 | New Zealand J Agri Res1994，37，： | 1 |
| 9 | Cesarean section scar diver- ticu-lum : appearance on hysterosal pingography 显示文摘 | Surapaneni K Silberzweig JE | 2008 | Am J Roent-genol2008，190，4： | 1 |
| 10 | Cesarean section scar diverticu-lum :appearance on hysterosal pingography显示文摘 | Surapaneni K Silberzweig JE | 2008 | Am J Roent-genol2008，190，4： | 1 |
| 11 | Cesarean Section Scar Diverticu- lum: Appearance on Hysterosalpingography 显示文摘 | Surapaneni K Silberzweig JE | 2008 | Am J Roent- genol2008，190，： | 1 |
| 12 | Cesarean section scar diverticulum:appearance on hysterosalpingography显示文摘 | Surapaneni K Silberzweig JE | | 0，，04： | 1 |
| 13 | Cesarean section scardiverticulum: appearance on hysterosalpingography显示文摘 | Surapaneni K Silberzweig JE | 2008 | AJR Am J Roentgenol2008，190，4： | 1 |
| 14 | Biosynthesis of drug metabolites using microbes in hollow fiber cartridge reac- tors : case study of diclofenac metabolism by Actinoplanes species 显示文摘 | Osorio-Lozada A Surapaneni S Skiles G L | 2008 | Drug Metabolism and Disposition2008，36，2： | 1 |
| 15 | Cesarean section scar diverticulum:appearance on hysterosalpingography显示文摘 | Surapaneni K Silberzweig JE | 2008 | AJR AmJ Roentgenol2008，190，4： | 1 |
| 16 | Pneumothorax following ultrasound-guided jugular vein puncture for central venous access in interventional radiology: 4 years of experience显示文摘 | Oner B Karam AR Surapaneni P | 2012 | J Intensive Care Med2012，27，： | 1 |
| 17 | Status of lipid peroxidation, glutathione, aseorbic acid, vitam in E and antioxidant enzymes in patients with osteoarthritis 显示文摘 | Surapaneni K M Venkataramana G | 2007 | Indian J Med Sei2007，61，1： | 1 |
| 18 | Oxidative stress and an- tioxidant enzyme activity in South Indian male smokers with chronic obstructive pulmonary disease 显示文摘 | Arja C Surapaneni KM Raya P | 2013 | Respirology2013，18，7： | 1 |
| 19 | Cesarean section scar di- verticulum: Appearance on hysterosal pingography显示文摘 | Surapaneni K Silberzweig JE | 2008 | A JR Am J Roentgenol2008，190，4： | 1 |
| 20 | Cesarean section Sear diverticulum appearance on hystero-salpingography显示文摘 | SURAPANENI K SILBERZWEIG JE | 2008 | Am J Roentgennol2008，190，4： | 1 |
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