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| 1 | 评估大气细颗粒物暴露引起的全球疾病负担的一个综合风险函数显示文摘[背景]评估由于环境空气中细颗粒物(PM2.5)长期暴露引起的疾病负担,需要了解相对风险度(RR)函数的图形和幅度。然而,在世界上很多观察到高PM2.5环境浓度的地方,都缺乏足够的直接证据确定死亡RR函数的图形。[目的]建立可用于全球PM2.5暴露范围内成人死因的RR函数:缺血性心脏病(IHD)、脑血管疾病(脑卒中)、慢性阻塞性肺病(COPD)和肺癌(LC)。建立急性下呼吸道感染(ALRI)发病的RR函数,用于估算〈5岁的儿童中死亡率和健康生活损失年数。[方法]通过整合现有的来自于环境空气污染(AAP)、二手烟草烟雾、家用固体烹饪用燃料和主动吸烟(AS)等研究的RR信息,拟合综合暴露-反应(IER)模型。采用颗粒物质的吸入剂量,通过转化AS暴露来估计全年PM2.5的暴露当量。在估算全球环境PM2.5浓度的基础上,得出各国的人群归因分数(PAFs)。[结果]与以往负担评估中使用的其他7种模型相比,IER模型是一种优越的RR预测方法。在不同国家中,归因于AAP暴露的PAF百分数各不相同,分别为:IHD,2~41;脑卒中,1~43;COPD,〈1~21;LC,〈1~25;ALRI,〈1~38。[结论]我们建立了一种以细颗粒物为基础的RR模型,它通过整合来自不同类型的燃烧所产生颗粒物排放的RR信息,涵盖全球范围的暴露。当获得新的RR信息时,可以对这个模型进行更新。 | Richard T.Burnett C.Arden Pope III Majid Ezzati Casey Olives Stephen S.Lim Sumi Mehta Hwashin H.Shin Gitanjali Singh Bryan Hubbell Michael Brauer H.Ross Anderson Kirk R.Smith John R.Balmes Nigel G.Bruce Haidong Kan Francine Laden Annette Prüss-Ustün Michelle C.Turner Susan M.Gapstur W.Ryan Diver Aaron Cohen 何蓉 张伊人 金泰廙 | 2014 | 环境与职业医学2014，31，11： | 80 |
| 2 | Tau-induced neurodegeneration: mechanisms and targets显示文摘The accumulation of hyperphosphorylated tau is a common feature of several dementias. Tau is one of the brain microtubule-associated proteins. Here we discuss tau's functions in microtubule assembly and stabilization and with regard to its interactions with other proteins. We describe and analyze important post-translational modifications: hyperphosphorylation, ubiquitination, glycation, glycosylation, nitration, polyamination, proteolysis, acetylation, and methylation. We discuss how these post-translational modifi cations can alter tau's biological function. We analyze the role of mitochondrial health in neurodegeneration. We propose that microtubules could be a therapeutic target and review different approaches. Finally, we consider whether tau accumulation or its conformational change is related to tau-induced neurodegeneration, and propose a mechanism of neurodegeneration. | Cindy Beharry Leah S. Cohen Jing Di Kawsar Ibrahim Susan Briffa-Mirabella Alejandra del C. Alonso | 2014 | Neuroscience Bulletin2014，30，2： | 6 |
| 3 | What makes teams work: Group effectiveness research from the shop floor to the executive suite显示文摘 | Susan G. Cohen Diane E. Bailey | 1997 | Journal of Management1997，，3： | 4 |
| 4 | 在电休克治疗中重复间歇使用依托咪酯不会造成持久的肾上腺皮质功能抑制显示文摘依托咪酯作为一种麻醉诱导用药,在20世纪80年代开始用于危重症患者机械通气的镇静。然而Ledingham等1983年在柳叶刀的报道指出:接受依托咪酯治疗的患者死亡率远高于未接受此治疗的同类患者。此后一系列相关研究阐明了其机制并导致此项应用的终止。多项研究表明依托咪酯会抑制肾上腺皮质功能,即使单次剂量也可造成此抑制,虽然单次剂量的抑制是短暂的。 | Philip Lebowitz Susan Cohen Shiry Weisberg Bernard Wyszynski Charles Ramesar Peter Pfeiffer | 2013 | 临床麻醉学杂志2013，29，6： | 2 |
| 5 | Modularity: Implications for imitation, innovation and sustained advantage 显示文摘 | FRITS K PIL SUSAN K COHEN | 2006 | Academy of Management Review2006，31，4： | 1 |
| 6 | Manufacturer benefits from information integration with retail customers 显示文摘 | SUSAN COHEN KULP HAUL LEE ELIE OFEK | 2004 | Man- agement Science2004，50，4： | 1 |
| 7 | Estimation Risk and Incentive Contracts for Portfolio Managers显示文摘 | | 1988 | Management Science1988，34，9： | 1 |
| 8 | Genetic and Metabolic Determinants of Plasma PCSK9 Levels显示文摘 | Susan G. Lakoski Thomas A. Lagace Jonathan C. Cohen Jay D. Horton Helen H. Hobbs | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，7： | 1 |
| 9 | Manufacturer Benefits from Information Integration with Retail Customers显示文摘 | Susan Cohen Kulp Hau L. Lee Elie Ofek | 2004 | Management Science2004，，4： | 1 |
| 10 | Aspirin resistance associated with HbA1c and obesity in diabetic patients显示文摘 | Hillel W. Cohen Jill P. Crandall Susan M. Hailpern Henny H. Billett | 2008 | Journal of Diabetes and Its Complications2008，，3： | 1 |
| 11 | Augmented Short- and Long-Term Hemodynamic and Hormonal Effects of an Angiotensin Receptor Blocker Added to Angiotensin Converting Enzyme Inhibitor Therapy in Patients With Heart Failure显示文摘 | Lawrence Baruch Inder Anand Ira S. Cohen Susan Ziesche Dianne Judd Jay N. Cohn | 1999 | Circulation1999，，20： | 1 |
| 12 | A morphologic analysis of sessile serrated polyps observed during routine colonoscopy (with video )显示文摘 | Uma S. Tadepalli Dennis Feihel Kenneth M. Miller Steven H. Itzkowitz Joseph S. Freedman Susan Kornacki Lawrence B. Cohen Neville D. Bamji Carol A. Bodian James Aisenberg | 2011 | Gastrointestinal Endoscopy2011，，6： | 1 |
| 13 | Adjunct ultrasonography in children with suspected acute appendicitis: identifying the optimal target group显示文摘 | Harsha M. Bullapur Aniruddh V. Deshpande Susan J. Phin Ralph C. Cohen | 2014 | ANZ J Surg2014，，5： | 1 |
| 14 | The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration显示文摘 | Irving F. Hoffman Charles S. Jere Terrie E. Taylor Peter Munthali John R. Dyer Jack J. Wirima Stephen J. Rogerson Newton Kumwenda Joe J. Eron Susan A. Fiscus Hrishitesh Chakraborty Taha E. Taha Myron S. Cohen Malcolm E. Molyneux | 1999 | Aids1999，，4： | 1 |
| 15 | Reconciling Media Access with Confidentiality for the Individual in Juvenile Court显示文摘 | Susan D Cohen | 1980 | Santa Clara Law Review1980，20，： | 1 |
| 16 | Crohn’s Disease and Ulcerative Colitis Are Associated With the DNA Repair Gene MLH1显示文摘 | Richard M. Pokorny Annegret Hofmeister Susan Galandiuk Allan B. Dietz Noah D. Cohen Holly L. Neibergs | 1997 | Annals of Surgery1997，，6： | 1 |
| 17 | A randomized trial assessing the impact of phenotypic resistance testing on antiretroviral therapy 显示文摘 | Calvin J Cohen Susan Hunt Michael Sension | 2002 | ADIS :2002，16，4： | 1 |
| 18 | The Efficacy of Acupuncture in Treating Urge and Mixed Incontinence in Women Wound显示文摘 | Sandra Engberg Susan Cohen Susan M | 2009 | Ostomyand Continence Nuring2009，36，6： | 1 |
| 19 | Mammary Ductoscopy for Evaluation of Nipple Discharge显示文摘 | Edna Kapenhas-Valdes MD Sheldon M. Feldman MD FACS Jean-Marc Cohen MD Susan K. Boolbol MD | 2008 | Annals of Surgical Oncology2008，，10： | 1 |
| 20 | Developing Research Competence to Support Evidence-Based Practice显示文摘 | Lora E. Burke Elizabeth A. Schlenk Susan M. Sereika Susan M. Cohen Mary Beth Happ Janice S. Dorman | 2005 | Journal of Professional Nursing2005，，6： | 1 |
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