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| 1 | Antimicrobial activity of mangrove plant(Lumnitzera littorea)显示文摘Objective:To investigate the antimicrobial activities of n-hexane.ethyl acetate and methanol extracts of the leaves of Lumnitzera littorea(L littorea) against six human pathogenic microbes. Methods:The antimicrobial activity was evaluated using disc diffusion and microdilution methods.Results:The antimicrobial activities of the crude extracts were increased with increasing the concentration.It is clear that n-hexane extract was the most effective extract. Additionally.Gram positive Bacillus cereus(B.cereus) appear to be the most sensitive strain while Pseudomonas aeruginosa(P.aeruginosa) and the yeast strains(Candida albicans(C. albicans) and Cryptococcus neoformans(C.neqformans)) appear to be resistance to the tested concentrations since no inhibition zone was observed.The inhibition of microbial growth at concentration as low as 0.04 mg/ml.indicated the potent antimicrobial activity of L littorea extracts.Conclusions:The obtained results are considered sufficient for further study to isolate the compounds responsible for the activity and suggesting the possibility of finding potent antibacterial agents from L littorea extracts. | Shahbudin Saad Muhammad Taher Deny Susanti Haitham Qaralleh Nurul Afifah Binti Abdul Rahim | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，7： | 7 |
| 2 | Antimicrobial activity and essential oils of Curcuma aeruginosa,Curcuma mangga,and Zingiber cassumunar from Malaysia显示文摘Objective:To analyze the chemical composition of the essential oils of Curcuma aeruginosa (C.aeruginosa),Curcuma mangga(C.mangga),and Zingiber cassumunar(Z.cassumunar). and study their antimicrobial activity.Methods:Essential oils obtained by steam distillation were analyzed by gas chromatography-mass speclrometry(GC-MS).The antimicrobial activity of the essential oils was evaluated against four bacteria:Bacillus cereus(H.cereus).Staphylococcus aureus(S.aureus).Escherichia coli(E.coli).and Pseudomonas aeruginosa(P.aeruginosa);and two fungi:Candida albicans(C.albicans) and Cyptococcus neoformans(C.neoformans),using disc-diffusion and broth microdilution methods.Results:Cycloisolongifolene,8.9-dehydro-9- formyl(35.29%) and dihydrocoslunolide(22.51%) were the major compounds in C.aeruginosa oil; whereas caryophyllene oxide(18.71%) and caryophyllene(12.69%) were the major compounds in C.mangga oil:and 2,6.9,9-tetramethyl-2.6.10-cycloundecatrien-1-one(60.77%) andα-caryophyllene(23.92%) were abundant in Z.cassumunar oil.The essential oils displayed varying degrees of antimicrobial activity against all lested microorganisms.C.mangga oil had the highest and most broad-spectrum activity by inhibiting all microorganisms tested,with C.neoformans being the most sensitive microorganism by having the lowest minimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) values of 0.1μL/mL. C.aeruginosa oil showed mild antimicrobial activity,whereas Z.cassumunar had very low or weak activity against the tested microorganisms.Conclusions:The preliminary results suggest promising antimicrobial properties of C.mangga and C.aeruginosa,which may be useful for food preservation,pharmaceutical treatment and natural therapies. | Tg Siti Amirah Tg Kamazeri Othman Abd Samah Muhammad Taher Deny Susanti Haitham Qaralleh | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，3： | 5 |
| 3 | Apoptosis,antimicrobial and antioxidant activities of phytochemicals from Garcinia malaccensis Hk.f显示文摘Objective:To study the chemical constituents of stembark of Garcinia malaccenm(G.malaccenm) together with apoptotic.antimicrobial and antioxidant activities.Methods:Purification and structure elucidation were carried out by chromatographic and spectroscopic techniques, respectively.MTT and trypan blue exclusion methods were performed to study the cytotoxic activity.Antibacterial activity was conducted by dise diffusion and microdilulion methods, whereas antioxidant activities were done by ferric thiocyanate method and DPPH radical scavenging.Results:The phylochemical study led lo the isolation ofα,β-mangostin and cycloarl-24-en-3β-ol.α-Mangostin exhibited cytotoxic activity against HSC-3 cells with an IC50 of 0.33μM.β- andα-mangostin showed activity against K562 cells with IC50 of 0.40μM and 0.48μM,respectively,α-Mangostin was active against Gram-positive bacteria, Staphylococcus aureus(S.aureus) and Bacilus anthracis(B.anthmcis) with inhibition zone and MIC value of(19 mm;0.02S mg/mL) and(20 mm;0.013 mg/mL),respectively.In antioxidant assay,α-mangostin exhibited activity as an inhibitor of lipid peroxidation.Conclusions:G.malaccenm presenceα- andβ-mangostin and cycloart-24-en-3β-ol.β-Mangostin was found very active against H.SC-3 cells and KS62.The results suggest that mangoslins derivatives have the potential to inhibit the growth of cancer cells by inducing apoptosis.In addition,α-andβ-mangostin was found inhibit the growth of Cram-positive pathogenic bacteria and also showed the activity as an inhibitor of lipid peroxidation. | Muhammad Taher Deny Susanti Mohamad Fazlin Rezali Farah Syahidah Ahmad Zohri Solachuddin Jauhari Arief Ichwan Suhaib Ibrahim Alkhamaiseh Farediah Ahmad | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 5 |
| 4 | Qualitative analysis of catechins from green tea GMB-4 clone using HPLC and LC-MS/MS显示文摘Objective:To identify the bioactive compounds in catechins isolation and its components from green tea GMB-4 clone.Methods:Green tea GMB-4 clones were extracted with distilled water at 90C.Samples were eluted into the column with 10%ethanol.Subsequently,the column was eluted with95%ethanol and evaporated separately.Green tea extract was identified by thin layer chromatography.Catechins were separated by the stationary phase in column chromatography using polyamide with 10%ethanol eluent and 95%ethanol.The results of isolations were analyzed by high performance liquid chromatographic(HPLC)and LCMS/MS.Analysis of catechins by HPLC was done by external standard.Results:Fraction from 10%ethanol showed that four major peaks at retention time of1.663,2.367,2.950 and 4.890,indicated the presence of four catechins components including catechin,epicatechins,gallocatechin and epigallocatechin.Whereas,fraction from 95%ethanol showed two main peaks at retention time of 5.167 and 9.82,which indicated the presence of epigallocatechin gallate(EGCG)and epicatechin gallate(ECG).EGCG(m/z 459),epigallocatechin(m/z 307),ECG(m/z 443),and epicatechin(m/z 291)were isolated and separated successfully using HPLC and LC-MS/MS.Conclusions:The HPLC and LC-MS/MS methods were successfully tuned for the qualitative analysis of green tea extract with EGCG and ECG.Four major catechins were separated and identified by LC-MS/MS,such as EGCG,epigallocatechin,ECG and epicatechin.The result of HPLC analysis showed that EGCG and ECG were main components from catechins isolation of green tea GMB-4 clone. | Erna Susanti Ciptati Retty Ratnawati Aulanni'am Achmad Rudijanto | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，12： | 3 |
| 5 | Comparison of the morphology and structure of W03 nanomaterials synthesized by a sol-gel method followed by calcination^or hydrothermal treatment显示文摘 | Diah Susanti Stefanus Haryo N Hasnan Nisfu Eko Prasetio Nugroho Hariyati Purwaningsih GeorgeEndri Kusuma Shao-Ju Shih | 2012 | Frontiers of Chemical Science and Engineering2012，6，4： | 3 |
| 6 | Antifungal and Antibacterial Activities of Four Malaysian Sponge Species (Petrosiidae)显示文摘 | H. Qaralleh S. Idid S. Saad D. Susanti M. Taher K. Khleifat | 2010 | Journal de Mycologie Médicale2010，，4： | 2 |
| 7 | Antioxidant and cytotoxic flavonoids from the flowers of Melastoma malabathricum L显示文摘 | Deny Susanti Hasnah M Sirat Farediah Ahmad | 2007 | Food Chemistry2007，103，： | 1 |
| 8 | Error diagnostics and data reconciliation for activated sludge modelling using mass balance 显示文摘 | Meijer S C F van der Spoel H Susanti S | 2002 | Water Sci Technol2002，45，6： | 1 |
| 9 | The preparation of dye sensitized solar cell(DSSC)from Ti O2and tamarillo extract显示文摘 | Susanti D Nafi M Purwaningsih H Fajarin R Kusuma G E | 2014 | Procedia Chemistry2014，9，： | 1 |
| 10 | Antioxidant and cytotoxic flavonoids from the flowers of melastoma malabathricum 1显示文摘 | SUSANTI D SIRAT H M AHMAD F | 2007 | Food Chemistry2007，103，3： | 1 |
| 11 | Error diagnostics and data reconciliation for activated sludge modelling using mass balances 显示文摘 | MEIJER S VANDER S H SUSANTI S | 2002 | Water Sci Technol2002，45，6： | 1 |
| 12 | Amides,triterpene and flavonoids from the leaves of melastoma malalathricum l显示文摘 | SIRAT H M SUSANTI D AHMAD F | 2010 | Journal of Natural Medicines2010，64，4： | 1 |
| 13 | Anti-inflammatory action of components from melastoma malabathricum显示文摘 | MAZURA M P SUSANTI D RASADAH M A | 2007 | Pharmaceutical Biology2007，45，5： | 1 |
| 14 | Thioredoxin targets fundamental processes in a methane-producing archaeon, Methanocaldococcus jannaschii显示文摘 | Susanti D Wong JH Vensel WH | 2014 | Proc Natl Acad Sci U S A2014，111，7： | 1 |
| 15 | Tumor specificcytotoxicity of arctigenin isolated from herbal plant Arctium lappah显示文摘 | Susanti S Iwasaki H Itokazu Y | 2012 | J Nat Med2012，66，： | 1 |
| 16 | A new strategy for ultralow biofouling membranes: Uniform and ultrathin hydrophilic coatings using liquid carbon dioxide显示文摘 | Ratna F. Susanti Yang Soo Han Jaehoon Kim Young Haeng Lee Ruben G. Carbonell | 2013 | Journal of Membrane Science2013，，： | 1 |
| 17 | Antimicrobial activity and chemical composition of essential oil of Malaysian Etlingera elatior(Jack)RM smith flowers显示文摘 | Susanti D Awang NA Qaralleh H | 2013 | J Essent Oil Bear Pl2013，16，2： | 1 |
| 18 | Antioxidant and cytotoxic flavonoids from the flowers of Melastoma mala- bathricum L显示文摘 | Deny Susanti Hasnah M Sirat Farediah Ahmad | 2007 | Food chemistry2007，103，： | 1 |
| 19 | Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L显示文摘 | SUSANTI S IWASAKI H ITOKAZU Y | | 0，，04： | 1 |
| 20 | Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L.显示文摘 | Siti Susanti Hironori Iwasaki Yukiyoshi Itokazu Mariko Nago Naoyuki Taira Seikoh Saitoh Hirosuke Oku | 2012 | Journal of Natural Medicines2012，，： | 1 |
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