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| 1 | 国内外64层螺旋CT诊断冠心病研究差异的荟萃分析显示文摘目的 用荟萃分析方法评价64层螺旋CT诊断冠心病的价值,比较国内外研究的差异.方法 检索Cochrane图书馆、Medline、OVID数据库以及中国期刊网1998至2009年公开发表的国内外文献,按照纳入标准筛选文献.对纳入的研究进行异质性检验,并选择相应的效应模型对所有研究定量合并,计算汇总敏感度、特异度及其95%可信区间,绘制汇总受试者工作特征 (SROC) 曲线并计算曲线下面积,并且进行国内外研究的对比分析.结果 共检索到文献433篇,排除研究目的或设计不符的文献后,共纳入108篇(国内62篇,国外46篇).由于无金标准、无盲法、无法计算数据而剔除的国内外文献分别为7篇和20篇(P〉0.05)、44篇和6篇(P〈0.05)、3篇和1篇(P〈0.05),最终获取文献27篇.国内文献8篇,64层螺旋CT评价血管段的汇总灵敏度、特异度和SROC曲线下面积分别为0.892(95%CI:0.868~0.913)、0.972(95%CI:0.966~0.977)和0.983(95%CI:0.966~1.000);国外文献19篇,64层螺旋CT评价患者的汇总灵敏度、特异度和SROC曲线下面积分别为0.971(95%CI:0.957~0.982)、0.878(95%CI:0.852~0.902)和0.973(95%CI:0.958~0.989),评价血管支的汇总灵敏度、特异度和SROC曲线下面积分别为0.917(95%CI:0.895~0.936)、0.919(95%CI:0.909~0.928)和0.974(95%CI:0.964~0.984);评价血管段的汇总灵敏度、特异度和SROC曲线下面积分别为0.882(95%CI:0.868~0.895)、0.959(95%CI:0.956~0.962)和0.985(95%CI:0.978~0.992).国内外64层螺旋CT血管段汇总特异度差异有统计学意义(P〈0.05).结论 荟萃分析表明,64层螺旋CT在诊断冠心病时,有较高的灵敏度和特异度.国外研究的诊断试验设计较国内研究严谨,结果可信度较高. | 李文玲 翟晓辉 于学文 杨健 Sushila Banymandhub 郭佑民 郭玉林 | 2011 | 中华心血管病杂志2011，39，6： | 9 |
| 2 | Retake the Center Stage-New Development of Rat Genetics显示文摘The rat is a powerful model for the study of human physiology and diseases,and is preferred by physiologists,neuroscientists and toxicologists.However,the lack of robust genetic modification tools has severely limited the generation of rat genetic models over the last two decades.In the last few years,several gene-targeting strategies have been developed in rats using N-ethyl-N-nitrosourea(ENU), transposons,zinc-finger nucleases(ZFNs),bacterial artificial chromosome(BAC) mediated transgenesis,and recently established rat embryonic stem(ES) cells.The development and improvement of these approaches to genetic manipulation have created a bright future for the use of genetic rat models in investigations of gene function and human diseases.Here,we summarize the strategies used for rat genetic manipulation in current research.We also discuss BAC transgenesis as a potential tool in rat transgenic models. | Sushuang Zheng Kindiya Geghman Sushila Shenoy Chenjian Li | 2012 | Journal of Genetics and Genomics2012，39，6： | 7 |
| 3 | In-vitro cytotoxic activity of β-Sitosterol triacontenate isolated from Capparis decidua(Forsk.) Edgew显示文摘Objective:To study the isolation and characterization of the constituent responsible for the cytotoxic activity of the ethanolic extract of stem of Capparis decidua(C.decidua).Methods:The preliminary cytotoxic effect of isolated compound(β-Sitosterol triacontenate) was investigated by MTT assay on A549 solid tumor cells.Results:IC50 value of theβ-Sitosterol triacontenate was found to be 1μM.The cytotoxic activity increased in a dose dependent manner in case ofβ-Sitosterol triacontenate.Conclusions:The data therefore provide direct evidence for the role ofβ-Sitosterol triacontenate as a potent antimetastatic agent,which can markedly inhibit the metastatic and invasive capacity of malignant cells. | Permender Rathee Dharmender Rathee Deepti Rathee Sushila Rathee | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，3： | 5 |
| 4 | 游走脾:手术之謎显示文摘Wandering spleen,also referred to as‘ptotic spleen’,is a rare clinical condition characterized by splenicmigration form its normal left hypochondrial position to any other abdominal or pelvic position.Among themultifactorial etiologies proposed,laxity of the spleen’s primary supporting ligaments is themost agreed-upon hypothesis.We present one rare case of wandering spleen in an 11-year-old girl who presented with recurrent abdominal pain with no localizing features.Her abdominal examination revealed an intra-abdominal left iliac fossa lump with restrictedmobility,which was confirmed as a wandering spleen by abdominal sonography and contrast-enhanced computed tomography.Intraoperatively,an infarcted spleen was encountered with tortuous,elongated,torsional splenic pedicle and a single dense adhesive band with descending colon.Splenectomy was offered to the patient.Post-operatively,the patient is healthy and symptom free at one-year follow-up.The rare clinical diagnosis of this condition,particularly in the paediatric age-group,makes it an enigma for the surgical world. | Ashok Kumar Puranik Rohit Mehra Sushila Chauhan Rahul Pandey | 2017 | Gastroenterology Report2017，5，3： | 2 |
| 5 | Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation 显示文摘 | Sushila K Glicerio A Lishan S | 2007 | AIDS Res Hum Retro2007，23，11： | 1 |
| 6 | Extra-gastrointestinal stromal tumor arising in the pancreas:a case report and litreature review显示文摘 | Sah Rambabu Kumari Sushila Yi Zhang | 2012 | J GHR2012，21，5： | 1 |
| 7 | Pediatric Anesthesia Emergence Delirium Scale:A diagnostic metaanalysis显示文摘BACKGROUND Emergence delirium(EmD)is a troublesome motoric,emotional,and cognitive disturbance associated with morbidity.It is often misdiagnosed despite being present in a substantial proportion of children and adolescents during emergence from anesthesia.AIM To evaluate the summary diagnostic accuracy of Pediatric Anesthesia Emergence Delirium Scale(PAEDS)for EmD among children and adolescents.METHODS Two researchers electronically and hand searched the published literature from May 2004 to February 2021 that evaluated the diagnostic accuracy of PAEDS for EmD among children and adolescents,using appropriate terms.Two independent researchers extracted the diagnostic parameters and appraised the study quality with QUADAS-2.Overall,the diagnostic accuracy of the measures was calculated with the summary receiver operating characteristic curve(SROC),the summary sensitivity and specificity,and diagnostic odds ratio(DOR)for EmD.Various diagnostic cut-off points were evaluated for their diagnostic accuracy.Heterogeneity was analyzed by meta-regression.RESULTS Nine diagnostic accuracy studies of EmD that conformed to our selection criteria and PRISMA guidelines were included in the final analysis.There was no publication bias.The area under the SROC was 0.97(95%confidence interval[CI]:95%-98%).Summary sensitivity and specificity were 0.91(95%CI:0.81-0.96;I2=92.93%)and 0.94(95%CI:0.89-0.97;I2=87.44%),respectively.The summary DOR was 148.33(95%CI:48.32-455.32).The effect size for the subgroup analysis of PAEDS cut-off scores of<10,≥10,and≥12 was 3.73,2.19,and 2.93,respectively;they were not statistically significantly different.The setting of the study and reference standard were statistically significantly related to the sensitivity of PAEDS but not specificity.CONCLUSION The PAEDS is an accurate diagnostic measure for the diagnosis of EmD among children and adolescents.Further studies should document its clinical utility. | Paul Swamidhas Sudhakar Russell Priya Mary Mammen Satya Raj Shankar Shonima Aynipully Viswanathan Grace Rebekah Sushila Russell Richa Earnest Swetha Madhuri Chikkala | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 1 |
| 8 | Stability of 6-gingerol and 6-shogaol in simulated gastric and intestinal fluids 显示文摘 | SUSHILA B VAN H T COLIN C D | 2007 | Journal of Pharmaceutical and Biomedical Analysis2007，45，： | 1 |
| 9 | Serotype specific primers and gel-based RT-PCR assays for 'typing african horse sickness virus: identification of strains from Africa 显示文摘 | Narender S M Sushila M Kyriaki N | 2011 | PLoS One2011，6，10： | 1 |
| 10 | Comparing the effect of IL-12 genetic adjuvant and alum non-genetic adjuvant on the efficiency of the cocktail DNA vaccine containing plasmids encoding SAG-1 and ROP-2 of Toxoplasma gondii显示文摘 | Kamy Khosroshahi Fatemeh Ghaffarifar Zohre Sharifi Sushila D’Souza Abdolhosein Dalimi Zuhair Hassan Fariba Khoshzaban | 2012 | Parasitology Research2012，，1： | 1 |
| 11 | Diagnostic accuracy and clinical utility of non-English versions of Edinburgh Post-Natal Depression Scale for screening post-natal depression in India:A meta-analysis显示文摘BACKGROUND The prevalence of post-natal depression(PND)is high in India,as it is in many other low to middle income countries.There is an urgent need to identify PND and treat the mother as early as possible.Among the many paper and pencil tests available to identify PND,the Edinburgh Postnatal Depression Scale(EPDS)is a widely used and validated measure in India.However,the summary diagnostic accuracy and clinical utility data are not available for this measure.AIM To establish summary data for the global diagnostic accuracy parameter as well as the clinical utility of the non-English versions of the EPDS in India.METHODS Two researchers independently searched the PubMed,EMBASE,MEDKNOW and IndMED databases for published papers,governmental publications,conference proceedings and grey literature from 2000-2018.Seven studies that evaluated the diagnostic accuracy of EPDS in five Indian languages against DSM/ICD were included in the final analysis.Two other investigators extracted the Participants’details,Index measures,Comparative reference measures,and Outcomes of diagnostic accuracy data,and appraised the study quality using QUADS-2.Deek’s plots were used to evaluate publication bias.We used the area under the curve of the hierarchical summary area under the receiver operating characteristic curve,with the random effect model,to summarize the global diagnostic accuracy of EPDS.Using the 2×2 table,we calculated positive and negative likelihood ratios.From the likelihood ratios,the Fagan’s nomogram was built for evaluating clinical utility using the Bayesian approach.We calculated the 95%confidence interval(95%CI)whenever indicated.STATA(version 15)with MIDAS and METANDI modules were used.RESULTS There was no publication bias.The area under the curve for EPDS was 0.97(95%CI:0.95-0.98).The pre-test probability for the nomogram was 22%.For a positive likelihood ratio of 9,the positive post-test probability was 72%(95%CI:68%,76%)and for a negative LR of 0.08,the negative post-test probability was 2%(95%CI:1%,3%).CONCLUSION In this meta-analysis,we established the summary global diagnostic parameter and clinical utility of the non-English versions of the EPDS in India.This work demonstrates that these non-English versions are accurate in their diagnosis of PND and can help clinicians in their diagnostic reasoning. | Paul Swamidhas Sudhakar Russell Swetha Madhuri Chikkala Richa Earnest Shonima Aynipully Viswanathan Sushila Russell Priya Mary Mammen | 2020 | World Journal of Psychiatry2020，10，4： | 1 |
| 12 | Against SQL Injection Attack An Unified Approach 显示文摘 | Sushila Madan Ms Supriya Madan Bulwark | 2010 | International Journal of Computer Science and Network Security2010，，5： | 1 |
| 13 | The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study显示文摘 | Bernd Frank Sushila H. Rigas Justo Lorenzo Bermejo Miriam Wiestler Kerstin Wagner Kari Hemminki Malcolm W. Reed Christian Sutter Barbara Wappenschmidt Sabapathy P. Balasubramanian Alfons Meindl Marion Kiechle Peter Bugert Rita K. Schmutzler Claus R. Bartr | 2008 | Breast Cancer Research and Treatment2008，，1： | 1 |
| 14 | IC performance of Indian pharma ceutical and textile industry显示文摘 | Karam Pal and Sushila Soriya | 2012 | Journal of Intellectual Capital2012，1，12： | 1 |
| 15 | A clinicopathological, immunohistochemical and neuroradiological study of eight patients with central neurocytoma显示文摘 | Sushila Jaiswal Mukul Vij Dinesh Rajput Anant Mehrotra Awadhesh Kumar Jaiswal Arun Kumar Srivastava Sanjay Behari Narendra Krishnani | 2010 | Journal of Clinical Neuroscience2010，，3： | 1 |
| 16 | Rapid cDNA synthesis and sequencing techniques for the genetic study of blue- tongue and other dsRNA viruses 显示文摘 | Sushila Maan Shujing Rao | 2007 | Journal of Viro- logical Methods2007，143，2： | 1 |
| 17 | Service quality anD previ-ous experience as a MoDerator inDeterMining tourists’satisfactionwith rural tourisM Destinations in Malaysia:A partial leastsquares approach显示文摘 | Sushila Devi RaJaratnaMa UMa Thevi Munikrishnana SaeeDPahlevan Sharifb Vikneswaran Naira | 2014 | ProceDia Social anD Behavioral Sciences2014，，144： | 1 |
| 18 | The stability of gingerol and shogaol in aqueous solution显示文摘 | Sushila B Van H T Colin C D | 2001 | J Pharm Sci2001，90，10： | 1 |
| 19 | Stability of -gingerol and -shogaol in simulated gastric and intestinal fluids 显示文摘 | SUSHILA B VAN H COLIN C | 2007 | Journal of Pharmaceutical and Biomedical Analysis2007，45，4： | 1 |
| 20 | Non-Hodgkin's Lymphoma of Colon:An Unusual Presentation显示文摘 | Sajid Ahamed Mudhol Sadhashivappa S Bedar Sushila P Garag | | 0，，01： | 1 |
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