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| 1 | Novel attapulgite/polyaniline/phosphomolybdic acid-based modified electrode for the electrochemical determination of iodate显示文摘 | Zhang Susu He Ping Lei Wen | 2014 | Journal of Electroanalytical Chemistry2014，724，4： | 1 |
| 2 | Mefatinib as first-line treatment of patients with advanced EGFR-mutant non-small-cell lung cancer:a phase Ib/II efficacy and biomarker study显示文摘EGFR inhibitors have revolutionized the treatment of advanced non-small-cell lung cancer(NSCLC).Mefatinib is a novel,bioavailable,second-generation,irreversible pan-EGFR inhibitor.This phase Ib/II open-label,single-arm,multi-center study investigated the efficacy,safety,biomarker,and resistance mechanisms of mefatinib in the first-line treatment of patients with advanced EGFR-mutant NSCLC.This study included 106 patients with EGFR-mutant stage IIIB-IV NSCLC who received first-line mefatinib at a daily dose of either 60 mg(n=51)or 80 mg(n=55).The primary endpoint was progression-free survival(PFS).Secondary endpoints were overall response rate(ORR),disease control rate(DCR),overall survival(OS),and safety.The cohort achieved an ORR of 84.9%and DCR of 97.2%.The median PFS was 15.4 months and the median OS was 31.6 months.Brain metastasis was detected in 29%of patients(n=31)at diagnosis and demonstrated an ORR of 87.1%,PFS of 12.8 months,and OS of 25.2 months.Adverse events primarily involved skin and gastrointestinal toxicities,which were well-tolerated and manageable.Analyses of mutation profiles were performed using targeted sequencing of plasma samples at baseline,first follow-up 6 weeks from starting mefatinib therapy(F1),and at progression.Patients with concurrent TP53 mutations had comparable PFS as wild-type TP53(14.0 vs 15.4 months;p=0.315).Furthermore,circulating tumor DNA clearance was associated with longer PFS(p=0.040)and OS(p=0.002).EGFR T790M was the predominant molecular mechanism of mefatinib resistance(42.1%,16/38).First-line mefatinib provides durable PFS and an acceptable toxicity profile in patients with advanced EGFR-mutant NSCLC. | Pingli Wang Yuping Li Dongqing Lv Lingge Yang Liren Ding Jianya Zhou Wei Hong Youfei Chen Dongqing Zhang Susu He Jianying Zhou Kai Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 3 | Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation显示文摘Acrylic acid(AA)is an important and widely used industrial chemical,but its high toxicity renders its use incompatible with the concept of green development.By leveraging its terminal carboxyl group and unsaturated bond,we designed and explored a new strategy to increase the greenness of AA via its eutectic melting using a quaternary ammonium salt(choline chloride)to form a deep eutectic solvent(DES),followed by polymerisation of the DES to form a polymer(poly(DES)).The greenness of AA,DES,and poly(DES)was evaluated via an in vitro test using MGC80-3 cells and an in vivo test using Kunming mice.The toxicity improved from Grade 2(moderately toxic)for AA to Grade 1(slightly toxic)for DESs and Grade 0(non-toxic)for poly(DES)in the in vitro test.Moreover,the poly(DES)s showed a lower toxicity in mice than the DESs in the in vivo test.Thus,greenness enhancement was successfully achieved,with the greenness following the order AA | Liteng Li Xiaofang Li Susu Zhang Hongyuan Yan Xiaoqiang Qiao Hongyan He Tao Zhu Baokun Tang | 2022 | Green Energy & Environment2022，7，4： | 0 |
| 4 | Corrigendum to “Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation” [Green Energy & Environ 7 (4) (August 2022) 840–853]显示文摘The authors regret that the name of the ethic committee that approved the study and the reference number was omitted from the published paper.In this research,all animal experiments were performed in accordance with the Guide for the Care and Use of Laboratory Animals(US National Institutes of Healh)and were approved by the Animal Welfare and Ethical Committee of Hebei University(No.IACUC-2020XG021,Baoding,China). | Liteng Li Xiaofang Li Susu Zhang Hongyuan Yan Xiaoqiang Qiao Hongyan He Tao Zhu Baokun Tang | 2024 | Green Energy & Environment2024，9，3： | 0 |
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