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| 1 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 2 | Hypothermia following acute carbon-monoxide poisoning increases mortality显示文摘 | Sutariya BB Penney DG Nallamothu BG | 1990 | Toxicol Lett1990，52，2： | 1 |
| 3 | Engineering tri- iodothyronine (T3) nanoparticle for use in ischemic brain stroke显示文摘 | Mdzinarishvili A Sutariya V Talasila PK | 2013 | Drug Deliv Transl Res2013，3，4： | 1 |
| 4 | A highly efficient PET switch on-off-on fluorescence receptor based on calyxarene for selective recognition of Cd2~ and Sr2+ 显示文摘 | Sutariya P G~ Pandya A Modi N R | 2013 | Analyst2013，138，8： | 1 |
| 5 | Preparation and properties of stable magnetic fluid using Mn substituted ferrite particles显示文摘 | Sutariya G M Upadhyay R V Mehta R V | 1993 | Journal of Colloid and Interface Science1993，155，1： | 1 |
| 6 | Preparation and properties of stable magnetic fluid using Mn substituted ferrite particles显示文摘 | Sutariya G M Upadhyay R V | 1993 | Journal of Colloid and Interface Science1993，155，： | 1 |
| 7 | Cardiovascular,metabolic and neurologic effects of carbon monoxide and cyanide in the rat显示文摘 | Dodds RG Penney DG Sutariya BB | 1992 | Toxicol Lett1992，61，： | 1 |
| 8 | Development and evaluation of fast-dissolving film of salbutamol sulphate显示文摘 | Mashru RC Sutariya VB Sankalia MG | 2005 | Drug Dev Ind Pharm2005，31，1： | 1 |
| 9 | Fusion tech-nique for liver transection with kelly-clysis and harmonictechnology显示文摘 | Jagannath P Chhabra DG Sutariya KR | 2010 | World J Surg2010，34，1： | 1 |
| 10 | Magnetic DC field and temperature dependence on complex microwave magnetic permeability of ferrofluids:effect of constituent elements of substituterd Mn ferrite 显示文摘 | Sutariya GM Vincent D Bayard B | 2003 | Magn magn Mater2003，260，： | 1 |
| 11 | 显示文摘 | | 1993 | Indian Journal of Pure & Applied Physics1993，31，： | 1 |
| 12 | 显示文摘 | Sutariya G M | 1993 | Journal of Colloid & Interlace Science1993，155，： | 1 |
| 13 | Development and evaluation of fast dissolving films of salbutamol sulphate 显示文摘 | Mashru RC Sutariya BC Parikh PP | 2005 | Drug Dev Ind Pharm2005，31，1： | 1 |
| 14 | Analytical detection and method development of anticancer drug Gemcitabine HCl using gold nanoparticles显示文摘 | Shobhana K. Menon Bhoomika R. Mistry Kuldeep V. Joshi Pinkesh G. Sutariya Ravindra V. Patel | 2012 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2012，，： | 1 |
| 15 | Suppression of transforming growth factor-βeffects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor显示文摘 | Sapitro J Dunmire JJ Scott SE Sutariya V Geldenhuys WJ Hewit M | 2010 | Mol Vis2010，16，： | 1 |
| 16 | Development and evaluation of fast dissolving films of salbutamol sulphate 显示文摘 | Mashru R C Sutariya B C Parikh P P | 2005 | Drug Dev Ind Pharm2005，31，1： | 1 |
| 17 | Role of nutritional factors in pathogenesis of cancer显示文摘Diet and nutrition are crucial factors throughout the complete life course in the promotion and upholding of good health.It has always been accepted that our defencelessness to infection and disease was influenced by diet and environmental as well as genetic factors.Nutrition is coming to the front position as a principle modifiable determinant of chronic disease,with scientific confirmation with time more supporting the view that alterations in diet have strong effects,equally positive as well as negative,on health throughout life.For the most part notably,nutritional adjustments may not only influence present health but also determine whether or not an individual will develop chronic non-communicable diseases like cancer.Diet is a blend of protective,mutagenic,and carcinogenic agents;the majority of them are metabolized by the enzymes of biotransformation process.Genetic polymorphisms that alter protein expression or else the function of these enzymes can change the risk of developing cancer.The scientific community has identified numerous naturally occurring materials in plant food with the power to resolve possible carcinogens.A few of these nutrients and natural phytochemicals look for toxins and usher them from the body before they can cause cell damage that may lead to cancer.Others give the impression to make it easier for the body to make repairs at the cellular level.At a standstill,others may help bring to an end cancer cells from reproducing.Even after a cell begins to experience damage that can lead to cancer,what you eat and drink,and how you live can still help short-circuit the cancer process.It is thought that a diet containing defensive micronutrients as well as carcinogens and mutagens may adapt the risk of cancer development,particularly in genetically susceptible individuals. | Anita Patel Yashwant Pathak Jayvadan Patel Vijaykumar Sutariya | 2018 | Food Quality and Safety2018，2，1： | 0 |
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