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| 1 | Viral and Antibody Kinetics of COVID-19 Patients with Different Disease Severities in Acute and Convalescent Phases:A 6-Month Follow-Up Study显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has spread rapidly around the world,posing a major threat to human health and the economy.Currently,long-term data on viral shedding and the serum antibody responses in COVID-19 patients are still limited.Herein,we report the clinical features,viral RNA loads,and serum antibody levels in a cohort of 112 COVID-19 patients admitted to the Honghu People’s Hospital,Hubei Province,China.Overall,5.36%(6/112)of patients showed persistent viral RNA shedding(>45 days).The peak viral load was higher in the severe disease group than in the mild group(median cycle threshold value,36.4 versus 31.5;P=0.002).For most patients the disappearance of IgM antibodies occurred approximately 4–6 weeks after symptoms onset,while IgG persisted for over 194 days after the onset of symptoms,although patients showed a 46%reduction in antibodies titres against SARS-CoV-2 nucleocapsid protein compared with the acute phase.We also studied18 asymptomatic individuals with RT-qPCR confirmed SARS-CoV-2 infection together with 17 symptomatic patients,and the asymptomatic individuals were the close contacts of these symptomatic cases.Delayed IgG seroconversion and lower IgM seropositive rates were observed in asymptomatic individuals.These data indicate that higher viral loads and stronger antibody responses are related to more severe disease status in patients with SARS-CoV-2 infection,and the antibodies persisted in the recovered patient for more than 6 months so that the vaccine may provide protection against SARS-CoV-2 infection. | Xiaoyong Zhang Suwen Lu Hui Li Yi Wang Zhen Lu Zhihong Liu Qingtao Lai Yali Ji Xuan Huang Yongyin Li Jian Sun Yingsong Wu Xiaoning Xu Jinlin Hou | 2020 | Virologica Sinica2020，35，6： | 4 |
| 2 | Effects of Epstein-Barr virus infection on the development of multiple myeloma after liver transplantation显示文摘Reduced cellular immune function in patients after liver transplantation easily results in many types of viral infections,such as Epstein-Barr virus.Epstein-Barr virus is a γ-herpesvirus and is related to many malignant diseases,especially epithelial and lymph tumors.The abnormal interaction of cluster of differentiation 40 with cluster of differentiation 40 ligand and expression of cluster of differentiation 40 ligand are considered closely related to the development of myeloma cells.This study explored the influence and mechanism of Epstein-Barr virus infection on the phenotype and biological behavior of myeloma cells after liver transplantation.Flow cytometry was used to detect coexpression of cluster of differentiation 40 and cluster of differentiation 40 ligand in 10 samples of freshly isolated multiple myeloma cells.Cluster of differentiation 40 and cluster of differentiation 40 ligand were coexpressed in sample Nos.5,8,9,and 10,particularly in sample No.5.Western blot analysis was used to detect the expression of the Epstein-Barr virus antigens latent membrane protein 1 and Epstein-Barr virus nuclear antigen 2 in the multiple myeloma cell line RPMI 8226 infected with Epstein-Barr virus.The antigen expression indicated that Epstein-Barr virus can infect multiple myeloma virus cells in vitro.Reverse transcription-polymerase chain reaction revealed upregulated expression of cluster of differentiation 40 ligand on the infected RPMI 8226 cells,which may be involved in the anti-apoptosis activity of the infected cells.Confocal microscopy showed that pairs of molecules of cluster of differentiation 40,cluster of differentiation 40 ligand,and latent membrane protein 1 were colocalized on the surface of the infected cells.CXC chemokine receptor 4 was upregulated on the RPMI 8226 cells after Epstein-Barr virus infection.The migratory ability of the infected cells improved in the presence of the chemokine stromal cell-derived factor-1α.Anti-apoptosis and migration are known important biological characteristics of malignant cells.Our results indicate the involvement of Epstein-Barr virus in the origin and development of multiple myeloma.The risk of multiple myeloma increases when Epstein-Barr virus infects B cells in the germinal center,which may result in an anti-apoptosis effect of B cells and an improved ability to migrate from the germinal center to peripheral blood. | ZHANG YeWei ZHAO HeWei HE Xia ZHENG SuWen WANG TaiHong YAN DongLiang SUN JingFeng LU Xiang WEN JianFei LAU Wan Yee | 2012 | Science China(Life Sciences)2012，55，8： | 2 |
| 3 | Photo-thermoelectric effect induced electricity in stretchable graphene-polymer nanocomposites for ultrasensitive strain sensing显示文摘Stretchable strain sensors play an increasingly important role in artificial intelligent devices.However,high-performanee strain sensors havebeen slowly developed owing to the harsh requirement of self-powered function,long cycle life and high resolution.Here,we report aself-powered stretchable graphene-ecoflex composite strain sensor based on photo-thermoelectric(PTE)effect induced electricity.Thedevice exhibits a high strain sensitivity of-0.056 In(nA)/%with strains ranged from 0%to 20%under 980 nm light illumination,where thestrain sensitivity can be found to in crease with in creasi ng light inte nsity.The strain sensor maintains outstanding dyn amic stability un derperiodic strains ranged from 0 to 100%in 100 cycles.The sensing resolution can be as high as 0.5%with both the response and recovery timeof less than 0.6 s.It can precisely monitor human joint motions and stretchable strains by implanting the device in pork. | Ding Zhang Yiding Song Lu Ping Suwen Xu De Yang Yuanhao Wang Ya Yang | 2019 | Nano Research2019，12，12： | 2 |
| 4 | Controllable synthe- sis of Bi2WO6 nanofibrous mat by electrospinning and enhanced visible photocatalytic degradation performances 显示文摘 | Zhao Gang Liu Suwen Lu Qifang | 2012 | Industrial & Engineering Chemistry Research2012，51，10： | 1 |
| 5 | 显示文摘 | Song Lingjun Liu Suwen Lu Qifang | 2012 | Applied Surface Science2012，258，8： | 1 |
| 6 | Preparation and photocatalytic properties of Zr4+ doped TiO2 nanocrystals显示文摘 | Wang Yanmin Liu Suwen Lu Mengkai | 2004 | Journal of Molecular Catalysis A:Chemical2004，215，12： | 1 |
| 7 | Preparation and photocatalytic properties of Zr^4+ - doped TiO2 nanocrystals 显示文摘 | WANG Yanmin LIU Suwen LU Mengkai | 2004 | Journal of Molecular Catalysis A : Chemical2004，215，： | 1 |
| 8 | Luminescence properties of Sr5 ( PO4 ) 3 Cl : Ni^2 + nanocrystals 显示文摘 | Xiu Zhiliang Lu Mengkai Liu Suwen Zhang Haiping Zhou Guangjun | 2006 | Materials Letters2006，60，： | 1 |
| 9 | Controllable synthesis of Bi2 WO6 nanofibrous mat by electrospinning and enhanced visible photocatalytic degradation performances显示文摘 | Gang Zhao Suwen Liu Qifang Lu Lingjun Song | 2012 | ndustrial & Engineering Chemistry Research2012，51，10： | 1 |
| 10 | Inactivity of YGL082W in vitro due to impairment of conformational change in the catalytic center loop显示文摘MINDY-1 is a recently discovered new family of deubiquitinating enzymes(DUB),but one of its yeast homologs,YGL082 W,does not show any DUB activity in vitro.Sequence alignment shows that YGL082 W possesses the correct catalytic triad,and yet did not catalyze either the hydrolysis of di-ubiquitin,crosslinking with C-terminally propargylated ubiquitin,or hydrolysis of ubiquitin-7-amino-4-methylcoumarin.After obtaining a crystal structure of the catalytic domain of YGL082 W,we identified an interesting difference between the catalytic center loop of YGL082 W and that of its human homolog MINDY-1.Because the conformation of the catalytic center loop was previously reported to be important for the deubiquitination activity of MINDY-1,we hypothesized that Glu27(instead of the corresponding Pro136 in MINDY-1) of the catalytic center loop of YGL082 W may impair the conformational change and account for the lack of activity.This hypothesis was supported by homology modeling and molecular dynamics simulations,which showed that the Pro-to-Glu mutation(P136 E mutation for MINDY-1) creates a hydrogen bond that inhibits the conformation change of the catalytic center loop of MINDY-1.Further experiments through site-directed mutation validated this hypothesis,showing that the P27 E mutation caused MIY1(a homologous active DUB from yeast) to lose activity. | Lining Lu Yu Guo Tian Wang Lujun Liang Suwen Zhao Feng Wang Lei Liu | 2020 | Science China Chemistry2020，63，2： | 1 |
| 11 | A core epitope targeting antibody of SARS-CoV-2显示文摘Dear Editor,Tremendous efforts have been made globally to develop therapeutics and prophylactics against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)which has caused thousands of millions of infections and deaths worldwide.A series of potent neutralizing antibodies with defined epitopes targeting RBD have been recently identified with different strategies.However,being an RNA virus,the instability of the SARS-CoV-2 genome results in numerous S-protein variants with altered viral phenotypes. | Simeng Zhao Fengjiang Liu Shizhen Qiu Qiaoshuai Lan Yiran Wu Wei Xu Junzi Ke Jie Yang Xiaoyan Liu Kun Wang Hangtian Guo Shuai Xia Fangfang Zhang Jiabei Wang Xiaowen Hu Lu Lu Shibo Jiang Suwen Zhao Lianxin Liu Youhua Xie Xiuna Yang Haopeng Wang Guisheng Zhong | 2023 | Protein & Cell2023，14，1： | 0 |
| 12 | 五羟色胺2C受体结构揭示GPCR多重药理学特性的结构基础显示文摘文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2C受体,对治疗肥胖、药物滥用和精神分裂症意义重大。 | 彭瑶 John D.McCorvy Kasper Harpsoe Katherine Lansu Shuguang Yuan Petr Popov Lu Qu Mengchen Pu Tao Che Louise F.Nikolajsen Xi-Ping Huang Yiran Wu Ling Shen Walden E.Bjorn-Yoshimoto Kang Ding Daniel Wacker Gye Won Han Jianjun Cheng Vsevolod Katritch Anders A.Jensen Michael A.Hanson Suwen Zhao David E.Gloriam Bryan L.Roth Raymond C.Stevens 刘志杰 | 2019 | 科学新闻2019，0，2： | 0 |
| 13 | 人源大麻素受体CB1晶体结构显示文摘人源大麻素受体(human Cannabinoid Receptor1,CB1)是G蛋白偶联受体(Gproteincoupledreceptor,GPCR)ClassA家族的一员.其主要分布在中怄神经系统,尤其是大脑皮层、基底核、海马和小脑区域,是人类大脑中表达量最高的GPCR之一. | Tian Hua Kiran Vemuri Mengchen Pu Lu Qu Gye Won Han Yiran Wu Suwen Zhao Wenqing Shui Shanshan Li Anisha Korde Robert B.Laprairie Edward L.Stahl Jo-Hao Ho Nikolai Zvonok Han Zhou Irina Kufareva Beili Wu Qiang Zhao Michael A.Hanson Laura M.Bohn Alexandros Makriyannis Raymond C.Stevens 刘志杰 | 2017 | 科学新闻2017，19，4： | 0 |
| 14 | 人源大麻素受体CB2的晶体结构显示文摘文章简介大麻素受体CB2主要分布在人体的免疫系统,选择性调控大麻素受体CB2对炎症、纤维化及神经退行性疾病等具有较好的治疗潜力,同时可避免由大麻素受体CB1引起的精神活性。本研究报道了大麻素受体CB2与新型拮抗剂AM0257复合物2.8埃分辨率的晶体结构。经结构对比分析,发现同处于拮抗状态的CB2与CB1不但结构差别极大。 | Xiaoting Li Tian Hua Kiran Vemuri Jo-Hao Ho Yiran Wu Lijie Wu Petr Popov Othman Benchama Nikolai Zvonok K’ara Locke Lu Qu Gye Won Han Malliga R.Iyer Resat Cinar Nathan J.Coffey Jingjing Wang Meng Wu Vsevolod Katritch Suwen Zhao George Kunos Laura M.Bohn Alexandros Makriyannis Raymond C.Stevens 刘志杰 | 2020 | 科学新闻2020，，2： | 0 |
| 15 | Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate显示文摘 | Biao Qiu Bingqing Xia Qingtong Zhou Yan Lu Miaomiao He Kazuya Hasegawa Zhiqiang Ma Fengyu Zhang Lichuan Gu Qionglei Mao Feng Wang Suwen Zhao Zhaobing Gao Jun Liao | 2018 | Cell Research2018，28，6： | 0 |
| 16 | Control of Chaos in Lu System Subject to Mismatch Uncertainties Using Sliding Mode Design显示文摘 | Xiaodong Xia Wanli Yang Qun Lu Suwen Zheng | 2008 | Journal of Systems Science and Information2008，6，4： | 0 |
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